Non Competitive Inhibition Flashcards
A variety of poisons such as ———- and ———- act as irreversible non competitive inhibitors
Iodoacetate
Heavy metal ions
Lead and mercury
Why increase in substrate concentration doesn’t reverse this Inhibtion
Inhibitors have no structural resemblance to substrate
Cyanide inhibits
Cytochrome oxidase
Fluoride
Removes magnesium and manganese ions
Inhibit enolase
Inhibits glycolysis
An example of reversible non competitive inhibition is
EDTA bind with calcium
Iodoacetate inhibits enzymes having —- grp
SH
——— is an antidote for heavy metal poisoning
British anti lewisite
Vmax is
Km is
Vmax is reduced
Km unchanged
Which is the nerve gas that binds to serine in acetylcholine esterase
Diisopropyl fluorophosphate
Treatment of alcoholism
Disulfiram
Disulfiram inhibits
Aldehyde dehydrogenase
—— binds to serine in bacterial cell wall
Penicillin
