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Enzyme Inhibiton > Competitive Inhibition > Flashcards

Competitive Inhibition Flashcards

1
Q

Inhibitor is a ———— of the substrate

A

Structural analog

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2
Q

Why is the reaction velocity reduced

A

Because
Half enzyme molecules are trapped but Inhibitor
Half molecules are available for catalysis to form product
Thus effective concentration of enzyme is reduced

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3
Q

An example of competitive inhibition is

A

Substrate succinate
Inhibitor malonate
Enzyme succinate dehydrogenase

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4
Q

Competitive inhibition is reversible or irreversible

A

Reversible

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5
Q

How can it be reversed

A

Excessive substrate concentration

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6
Q

Km ———— in présence of competitive inhibitor

A

Increases

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7
Q

Vmax is not changed

Why

A

Because on increasing substrate concentration it can be reversed

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8
Q

Allopurinol inhibits enzyme

A

Xanthine oxidase

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9
Q

Clinical use of allopurinol

A

Gout

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10
Q

Substrate allopurinol acts on

A

Hypoxanthine

Xanthine

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11
Q

Lovastatin inhibits ———

A

HMGCoA reductase

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12
Q

Substrate of lovastatin is

A

HMG CoA

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13
Q

Clinical use of HMG CoA

A

Cholesterol lowering

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14
Q

Bacteria synthesize folic acid by combining PABA with pteroyl glutamic acid in presence of enzyme

A

Pteroid synthétase

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15
Q

——— being structural analog of PABA will inhibit folic acid synthesis in bacteria

A

Sulfonamides

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16
Q

What is methotrexate

A

4 amino N10 methyl folic acid

17
Q

Methotrexate inhibits this enzyme

A

Dihydrofolate Reductase

18
Q

Methotrexate inhibits cell division and DNA synthesis so it’s used as

A

Anti cancer drug

19
Q

Dicoumarol is structurally similar to

A

Vit K

20
Q

Dicoumarol acts as an

A

Anticoagulant

21
Q

Dicoumarol inhibits

A

Vit k epoxide reductase

22
Q

Isonicotinic anhydride is used as ———- drug

A

Antituberculous

23
Q

INH is similar to ———

Thus prolonged use of INH results in peripheral neuropathy

A

Pyridoxal

24
Q

———— is used for methanol poisoning

A

Ethanol

25
Q

Ethanol competes with methanol for

A

Alcohol dehydrogenase

26
Q

Succinylcholine inhibits

A

Acetylcholine

Muscle relaxant

Enzyme Inhibiton (4 decks)

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