Substance Use Disorders Flashcards
Know mainly alcohol, opioids, and stimulants
Substance Use Disorder is a
cluster of cognitive, behavioral, and physiological symptoms indicating that the individual continues using the substance despite significant substance-related problems
use even though it causes the problems knowingly
Addiction –
chronic relapsing long lasting changes to the brain
Flashbacks –
drug free state, experiencing disturbances (hallucinations)
Tolerance –
reaction decrease with continued use (take more to see the same result)
Amotivational syndrome –
apathy with no motivation to do ADLs or societal role
Cross-tolerance
– one substance is also tolerance to another substance (morphine and other opioids)
Psychological dependence –
need for the drug subjectively and emotionally
Physical dependence
- no physical substance with no longer using the substance
Withdrawal –
psychological and physical dependence
Dual diagnosis –
substance use and other psych disorder as well
Goals for Substance Use Disorder Treatment
recognition of acute toxicity
facilitate of withdrawa
dx and tx medical complications of substance use
edu/counseling/therapy to sustain sobriety and long-term abstinence
10 categories of substances for abuse
caffeine
alcohol
nicotine
cannabis
dsedatives/hynotics/anxiolytics
opioids
stimulants
hallucinations
inhalants
**nutmeg and K2 and cough syrup
Substances have different types of reactions after taking a substance including
intoxication
toxicity
withdrawal
Abuse
Habitual use of a substance which falls outside of medical necessity or societal acceptance
Used solely for the purpose of altering mood, emotion or state of consciousness
Addiction
Chronic/relapsing disease
Compulsive substance-seeking behaviors motivated by cravings, despite harmful consequences
Long-lasting changes in the brain.
May include development of tolerance and withdrawal symptoms
SUD criteria
large amounts for a long period than intended
1+ unsuccessful to cut down or control use
time dedicated to obtain/use/recover
craving
failure to fulfill obligations (ADL or work)
persistent social problems
activities are neg. affected
continued use despite problems
hazardous situations in driving
tolerance
Tolerance of SUD
increased amounts to achieve intoxication/desired effect
diminished effects with continued use of the same amount
Withdrawal is manifested by
same substance taken to relieve or avoid withdrawal s/s
Mild SUD has how many criteria
2-3
Moderate SUD has how many criteria
4-5
Severe SUD has how many crieria
6+
Psychological risk factors for SUD
low frustration levels
poor impulse control
lack of meaningful relationships
childhood trauma
low self esteem
propensity for risk taking behaviors
Social risk factors for SUD
peer influences
family acceptance
Which gender has a greater risk for SUD
MALES
Patho of SUD
Brain reward system (reinforcement of behaviors and memories)
neurotransitters not effective
- double the amount of dopamine and floods the brain and neurotransmitters
Route Complications for SUD
IM/SubQ
scarring
lesions
abscesses
infections
Route Complications for SUD
IV
infectious
venous sclerosis
disease tranmission
endocarditis
- track marks on arms and legs with repeated injections
Route Complications for SUD
intranasal
Chronic sinusitis
Perforated nasal septum
Route Complications for SUD
smoking
respiratory problems
CNS Depressants are
alcohol
barbituates
bezodiazepines
- affect the GABA receptors
Barbituates are easier to
overdose
Benzodiazepines are extremely
addictive
Alcohol Use Disorder
- acute patho
binds with GABA/glutamate and dampens them
- activate reward circuit
- inhibits ADH (diuretic)
How much alcohol is too much?
4+ for men in 1 day or 14 in one week
3+ for women in 1 day or 7 in one week
Can moms drink alcohol and breastfeed at the same time?
no
Standard Drink formula
12 oz of beer =
8 oz of malt =
5 oz of wine =
1.5 oz o spirits
Life-threatening signs of alcohol poisoning
inability to wake up
vomiting
slow breathin <8
irregular breathing
seizures
hypothermia
0.05 mg = 1-2 drinks effects
chnages in mood and behavior, impaired judgment
0.08 mg = 5-6 drinks effects
legal limit of intoxication
-clumbsiness in voluntary activity
0.2 mg = 10-12 drinks effects
depressed fucntions
staggering and ataxia
emotional lability
0.3 mg = 15-19 drinks effects
confusion
stupor
0.4 mg = 20-24 drinks effects
coma
0.5 mg = 25-30 drinks effects
death by respiratory depression
CIWA evaluates for
N/V
Tactile disturbances
auditory and visual distrbances
anxiety
HA/fullness
orientation x4
tremor (stick out tongue and move fingers)
paroxymal sweats
agitation
In a CIWA, the nurse should get a BP and apical heart rate for how long
1 minute
If the CIWA score is _______ then notify the doctor
> 20
Alcohol Withdrawal peaks
within 24-48 hours
- rapid disappear unless goes to delirium
What is possible in 7-48 hours of an alcohol withdrawal
grand mal seizures
Alcohol withdrawal s/s
irritable
“shaking inside”
illusion (misinterpret)
early signs in a few hours
Delirium Tremens (rapid)
emergency and possible death
peak 2-3 days after cessation and reduction
autonomic hyperactivity
disturbances
fluctuating LOC
delusions
agitated
100+ temp
Autonomic hyperactivity
HTN
sweating
hyper/hypo thermia
The clock starts from the last
drink consumed
Acute withdrawal needs to be closely monitored on
BP and heart rate
Post-acute withdrawal syndrome
episodic
days to weeks
- up to 2 years
Post-acute withdrawal syndrome
s/s
Mood swings
Anxiety
Irritability
Tiredness
Variable energy
Low enthusiasm
Variable ability to concentrate
Disturbed sleep
Risks for Post-acute withdrawal syndrome
distressing
relapsing
- brain remodels to regular chemistry
Effects of chronic alcohol use
CV damage (cardiomyopathy),
liver damage (hepatitis, cirrhosis),
erosive gastritis,
GI bleed,
esophageal varices,
ascites,
acute pancreatitis,
thiamine deficiency,
peripheral neuropathy,
inc risk of cancer,
thrombocytopenia,
damage to the brain,
dilation of cutaneous blood vessels,
hypertension,
testicular atrophy, impotence, sterility, & breast enlargement in men
Wernicke’s encephalopathy
Inflammatory,
hemorrhagic,
degenerative condition of the brain
- caused by thiamine deficiency from poor diet & alcohol-induced suppression of thiamine absorption
Wernicke’s encephalopathy tx
- reversed if treated immediately and completely
- tx with tyramine and vitamin B
Wernicke’s encephalopathy can lead to
Korsakoff’s psychosis
Korsakoff’s psychosis
is a
irreversible form of amnesia with
- short term memory loss
- long term memory gaps
- inability to learn
Korsakoff’s psychosis
notable behavior
confusion
amnesia
Tx for Alcohol Withdrawal
1st Benzo (Lorazepam)
- cross tolerance taper
Gabapentin (low anxiety and prevent seizures)
Propanolol and Clondine (Beta and Alpha blocker) - autonmic and elevate vitals
Thiamine - prevent syndrome and correct high output heart failure
Folic acid, B12 (anemia and halt peripheral neuropathy)
If benzos aren’t effective in alcohol withdrawal, the nurse will
transfer to ICU and give barbituates - phenobarbital
Alcohol Withdrawal Sobriety
Naltrexone
opioid antagonist - block opioid recpetors with cravings
**reduce relapse
Alcohol Withdrawal Sobriety
Acamprosate (Campral)
reduce symptoms of long-lasting withdrawal insomnia, anxiety
Alcohol Withdrawal Sobriety
Disulfiram (Antabuse)
Interferes with breakdown of alcohol leading to unpleasant reactions such as flushing, NV
Stays in system up to 14 days
Alcohol Withdrawal Sobriety
Gabapentin (Neurontin)
Works on GABA to calm down the brain and mitigate hyper-aroused state
Reduces cravings by lowering anxiety, improving sleep
With Disulfiram, you should avoid alcohol for
14 days
- vanilla and mouthwash
Benzodiazepines toxicity s/s
Severe Confusion
Drowsiness
Lack of coordination/weakness
Lightheadedness
Memory loss
Fainting
Benzodiazepines overdose occurs with
ETOH, opiates, TCAs, or CNS depressants
Benzodiazepines withdrawal s/s
Body pain
Muscle tension
Cramping
Insomnia
Vomiting
Tremors
Sweating
Seizures
miserable
Benzodiazepines reversal agents
Flumazenil
Opiates include what types of drugs
Opium (poppy flower latex)
Oxycodone
Fentanyl
Heroin
Meperidine
Morphine
Codeine
Methadone
Hydromorphone
Heroin lipid solublity is
high
-easier to enter cells and overdose quicker
When Heroin crosses the blood-brain barrier it converts to
active form of morphine
Heroin effectiveness
IV
Internasal
7-8 sec
10-15 sec