Mood Disorders - Bipolar Flashcards
Van Gogh painting Old Man in Sorrow was painted shortly after his
1890 died AFTER D/C from an asylum
from self-inlficted GSW
Bipolar 1 Disorder consists of
At least one episode of “persistent or elevated, expansive or irritable mood” (mania), accompanied by changes in activity or energy.
A major depressive disorder episode is frequently included.
- social and work functioning is impaired
- psychosis accompany both
Bipolar 2 Disorder consists of
Includes at least one period of hypomania alternating with one or more periods of depression.
- no full mania episodes
- tx during depressive
Hypomania episodes requires
requires less sleep, inflated self-esteem, increased energy or activity, is distracted, may overspend, sexual indiscretions and impulsivity
Bipolar 2 has more
depressive s/s AND SPEND MORE TIME IN DEPRESSIVE STATE
Bipolar Specifiers
rapid cycling (4+ episodes in 12-month period)
mania- depression x4
Melancholic
Atypical
Peripartum
Seasonal
Psychotic and catatonic features
Melancoholic
depressive episodes with inability to feel pleasure
Atypical
depressive features that are not typical for the individual
Psychotic features in Bipolar
hallucinations
paranoia
delusions
Catatonic features for bipolar
extremes of physical activity or not moving at all
- Randy
Manic episode s/s (3+ for bipolar)
- inflated self-esteem or grandiosity (jesus, devil, president)
- decreased need for sleep (3 hours is good for them)
- more talkative and pressure to keep talking
- flight of ideas or racing thoughts
- distractibility (irrelevant)
- increase in goal-directed activities or psychomotor agitation
- excessive involvement in high potential painful consequences (shopping, sexual indiscretions, or investments)
The bipolar mood disturbances is sufficiently
severe to cause marked impairment in social or occupational functioning
If the manic episode continues for a long time, what issues could arise?
cardiac
Hypomanic criteria
4+ days
- unequivocal change in functioning that is uncharacteristic of the individual when not symptomatic.
- not severe enough to cause marked impairment in social or occupational functioning or to necessitate hospitalization
Delirious mania
rapid onset of delirium and mania
possible psychosis
Hyperactive catatonia - prominent
DO NOT STOP TO EAT AND ACUTE CONFUSION
Delirious mania is tx with
high doses of benzodiazepines and or ECT
Unipolar depression
affects women more
later in life
no appetite, no interest to eat
sleep with insomnia, problems staying asleep and falling asleep
lesser risk of drug abuse and suicide than bipolar
Bipolar Depression
men and women equal
younger
Binge eating- depressed; anorexia -mania
Hypersomnia and diff to wake in the morning
Greater isk of abuse and suicide
Cyclothymic Disorder
Hypomanic episodes alternating with persistent depressive episodes for at least 2 years or 1 year in children.
- irritable episodes
mood extemes severe than bipolar
stable mood periods
Initial presentation for male;females is
mania, and depression for females.
What other disorders could be accompanying bipolar cyclothymia?
anxiety
Impulse control, attention-deficit/hyperactivity and substance use disorders occur in over half of those with bipolar disorder.
Bipolar spectrum disorder has a higher rate of these medical comorbidity
especially cardiovascular and metabolic diseases, endocrine disorders, type 2 diabetes, and obesity.
Genetic Theory of BSD
First degree relatives of a person with bipolar disorder are 7-10 times more likely to develop bipolar disorder
both then 50%
Strongest predictor of later development of BSD is
displays premorbid symptoms of anxiety/depression, affective lability and low-level manic symptoms
Neurobiological Factors of BSD
in mania
HIGH dopamine, norepinephrine, and glutamate
Neurobiological Factors of BSD
in bipolar depression
low dopamine and norepinephrine
If serotonin is too low in BSD depression episode this can cause
agitation
poor impulse control in manic phase
GABA in BSD is
blunted