Substance P/Neurokinin 1 Receptor Antagonists

Question 1

Substance P/Neurokinin 1 Receptor Antagonists Drug Names

Answer 1

Aprepitant
Rolapitant

“-pitant”

Question 2

Substance P/Neurokinin 1 Receptor Antagonists Therapeutic Actions

Answer 2

• Act directly in the CNS to block receptors associated with nausea and vomiting

Question 3

Substance P/Neurokinin 1 Receptor Antagonists Indications

Answer 3

• Act directly in the CNS to block receptors associated with nausea and vomiting

Question 4

Substance P/Neurokinin 1 Receptor Antagonists Contraindications and Cautions

Answer 4

Contraindications:
• Allergy

Caution:
• Pregnancy and Lactation

Question 5

Substance P/Neurokinin 1 Receptor Antagonists DDI

Answer 5

• warfarin, hormonal contraceptives

Question 6

Substance P/Neurokinin 1 Receptor Antagonists Adverse Effects

Answer 6

• Anorexia, fatigue, constipation, diarrhea, liver enzyme elevation, dehydration

Question 7

Substance P/Neurokinin 1 Receptor Antagonists:

Assessment

Answer 7

Assess:
Hx: Allergy, pregnancy and lactation, impaired renal or hepatic function, active peptic ulcer disease, assess complaints of nausea
Physical: vital signs, orientation, affect, reflexes; coma, semiconscious state, CV status, assess abdomen and evaluate emesis; note color, amount and frequency of vomiting episodes (baseline)
Labs: monitor results

Question 8

Substance P/Neurokinin 1 Receptor Antagonists:

Diagnosis

Answer 8

• Acute pain
• Risk for injury
• Decreased cardiac output
• Deficient knowledge regarding drug therapy

Question 9

Substance P/Neurokinin 1 Receptor Antagonists:

Implementation

Answer 9

• Assure that the route of administration is appropriate
• Assess the patient carefully for any potential drug–drug interactions
• Provide other measures to help the patient cope with the discomfort of nausea and vomiting and drug effects
• Provide thorough patient teaching

Question 10

Substance P/Neurokinin 1 Receptor Antagonists:

Evaluation

Answer 10

Response to the drug 
Adverse effects
 Effectiveness of comfort measures
Compliance with regimen
Effectiveness of teaching plan