5-HT3 Receptor Blockers

Question 1

5-HT3 Receptor Blockers Drug Names

Answer 1

Granisetron
Ondansetron
Palonosetron

“-setron”

Question 2

5-HT3 Receptor Blockers Therapeutic Actions

Answer 2

• Blocks specific receptor sites associated with nausea and vomiting, peripherally and in the CTZ

Question 3

5-HT3 Receptor Blockers Indications

Answer 3

• Control of severe nausea and vomiting associated with antineoplastic chemotherapy and radiation therapy and postoperative nausea/vomiting

Question 4

5-HT3 Receptor Blockers Contraindications and Cautions

Answer 4

Contraindications:
• Allergy

Caution:
• Pregnancy and Lactation

Question 5

5-HT3 Receptor Blockers Adverse Effects

Answer 5

• HA
• Dizziness
• Myalgia
• Constipation

Question 6

5-HT3 Receptor Blockers:

Assessment

Answer 6

Hx: Allergy, pregnancy and lactation, impaired renal or hepatic function, active peptic ulcer disease, assess complaints of nausea
Physical: vital signs, orientation, affect, reflexes; coma, semiconscious state, CV status, assess abdomen and evaluate emesis; note color, amount and frequency of vomiting episodes (baseline)

Question 7

5-HT3 Receptor Blockers:

Diagnosis

Answer 7

• Acute pain
• Risk for injury
• Decreased cardiac output
• Deficient knowledge regarding drug therapy

Question 8

5-HT3 Receptor Blockers:

Implementation

Answer 8

• Assure that the route of administration is appropriate
• Assess the patient carefully for any potential drug–drug interactions
• Provide other measures to help the patient cope with the discomfort of nausea and vomiting and drug effects
• Provide thorough patient teaching

Question 9

5-HT3 Receptor Blockers:

Evaluation

Answer 9

Response to the drug 
Adverse effects
 Effectiveness of comfort measures
Compliance with regimen
Effectiveness of teaching plan