Phenothiazines

Question 1

Phenothiazines Drug Names

Answer 1

Prochlorperazine
Chlorpromazine
Perphenazine

“-azine”

Question 2

Phenothiazines Therapeutic Actions

Answer 2

• Depresses various areas of the central nervous system (CNS)

Question 3

Phenothiazines Indications

Answer 3

• Treatment of nausea and vomiting

Question 4

Phenothiazines Contraindications and Cautions

Answer 4

Contraindications:
• CNS depression: coma, brain damage or injury
• Severe hypotension or hypertension
• Severe liver dysfunction

Caution:
•	Renal dysfunction
•	Moderate liver impairment
•	Active peptic ulcer
•	Pregnancy and lactation

Question 5

Phenothiazines DDI

Answer 5

DDI:

• Other CNS depressants, including alcohol

Question 6

Phenothiazines Adverse Effects

Answer 6

• CNS effects: Drowsiness, dizziness, weakness, tremor, headache, photophobia
• CV effects: Hypotension, hypertension, cardiac arrhythmias
• GU effects: Menstrual disorders, galactorrhea, and gynecomastia

Question 7

Phenothiazines:

Assessment

Answer 7

Hx: Allergy, pregnancy and lactation, impaired renal or hepatic function, active peptic ulcer disease, assess complaints of nausea
Physical: vital signs, orientation, affect, reflexes; coma, semiconscious state, CV status, assess abdomen and evaluate emesis; note color, amount and frequency of vomiting episodes (baseline)
Labs: monitor results

Question 8

Phenothiazines:

Diagnosis

Answer 8

• Acute pain
• Risk for injury
• Decreased cardiac output
• Deficient knowledge regarding drug therapy

Question 9

Phenothiazines:

Implementation

Answer 9

• Assure that the route of administration is appropriate
• Assess the patient carefully for any potential drug–drug interactions
• Provide other measures to help the patient cope with the discomfort of nausea and vomiting and drug effects
• Provide thorough patient teaching

Question 10

Phenothiazines:

Evaluation

Answer 10

Response to the drug 
Adverse effects
 Effectiveness of comfort measures
Compliance with regimen
Effectiveness of teaching plan