Substance of Abuse Flashcards
Other names for Ethanol
Grain alcohol
Spiritus vini rectificatus
Neutral spirit
Most widely abused recreational substance
Ethanol
Responsible for major medical and socioeconomic problems
Ethanol
Alcohol content of Beer
4-5%
Alcohol content of Wine
10-14%
Alcohol content of Distilled spirits
30-50%
Metabolites of Alcohol
Acetaldehyde, Acetic Acid
S/S of Alcohol Poisoning
CNS depression, Acid-base Imbalance,
Metabolic Acidosis, Impaired Thermal Regulation
Hypoglycemia, Coma, Tachycardia
Treatment of Acute Alcohol Toxicity
Supportive Care
Fluids and Electrolytes
Vit B1 (Thiamine)
Treatment of Chronic Alcohol Poisoning
Disulfiram - Aldehyde dehydrogenase Inh
Naltrexone, Acamprosate - Reduce cravings and Inc. Abstinence rate
Behavioral Therapy
Active Ingredient of Tobacco
Nicotine
Lethal dose of Nicotine
Adult: 40-60mg
Child: 1.5 - 2 mg/kg
Treatment of Nicotine Toxicity
Activated Charcoal
Gastric Lavage
Mecamylamine (Inversine®)
From Papaver Somniferum (opium poppy)
Opioids
Natural Opioids
Opium, Morphine
Semi-synthetic Opioid
Heroin (Diacetylmrphine)
Codeine (Methylmorphine)
Synthetic Opioids
Methadone & Meperidine (Pethidine)
Opioid Toxicity Manifestations
Coma (LOC)
Miosis (pinpoint pupil)
Respiratory depression
Meperidine may cause
Seizure
Treatment for Opioids Toxicity
Naloxone
(pure Antagonist)
Naltrexone
Nalorphine
Nalmefen
Hallucinogens
Hallucinogens
Lysergic Acid Diethylamide (LSD)
Marijuana
Phencyclidine
Mescaline
Lysergic Acid Amide (LSA)
Marijuana is derived from?
Cannabis sativa/sativum
Other names for Marijuana
Mary Jane, Hashish, Indian Hemp, Weeds
Most commonly used Illegal Drug
Marijuana
Active constituent of Marijuana
△-9-tetrahydrocannabinol (THC)
Cannabidiol
Angel Dust
Phencyclidine
Dissociative anesthetic
Phencyclidine
S/S of Phencyclidine Poisoning
Low: Bloodshot eyes, Loss of balance
Med: Anesthesia, HPN
High: Convulsion
Tx of Phencyclidine poisoning
Benzodiazepine, Diazepam (for seizure)
Nitroprusside (for HPN)
Mescaline is derived from
Peyote cactus (Lophophora williamsii)
Mescaline Toxicity S/S
Sympathomimetic Toxidrome
TF: LSD is an Ergot derivative
True
Most potent hallucinogen
LSD
LSA is derived from
Morning glory family (Ipomoea indica)
Shabu
Methamphetamine
Ecstasy
3, 4-methylenedioxy-N-methamphetamine, or MDMA
S/S of Amphetamine poisoning
Seizures
Psychosis/Agitation
Hypertensive crisis
Arrhythmias
Treatment for Amphetamine Poisoning
Seizures: Diazepam, Phenytoin
Psychosis/Agitation: Chlorpromazine, haloperidol, Diazepam
Hypertensive crisis: B-blockers, a-blockers
Arrhythmias: Propanolo, Lidocaine
Cocaine is derived from
Erythroxylon coca
Cocaine
Crack, Freebase
Treatment of Cocaine Toxicity
Seizures: Benzodiazepine
Psychosis: Neuroleptics
HPN: Labetalol