Substance Misuse Flashcards
What factors can influence the development of addiction?
Genetics
Neurobiological
Social
Behavioural
Attachment
What are some worrying symptoms of an alcohol related presentation?
Head injury
Confusion
Shaking/seizures
Hallucinations
Vomiting blood or coffee grounds
Severe abdominal pain
Sudden jaundice
What are the common causes of alcohol related mortality?
Fights
Falls
Liver failure
Pancreatitis
Overdose
Withdrawal
Wernike’s Encephalopathy
What are some early symptoms of alcohol withdrawal?
Tremor
Sweating
Nausea
Anxiety
Tachycardia
What are some late symptoms of alcohol withdrawal?
Delirium
Disorientation
Hallucination
Tremor
Fever
Lack of motor co-ordination
What percentage of chronic alcoholics develop Wernike’s encephalopathy?
10%
What is the mortality rate of untreated Wernike’s encephalopathy?
15-20%
What are the symptoms of Wernike’s encephalopathy?
Ataxia
Nystagmus
Ophthalmoplegia
Vomiting
Altered level of consciousness
Fever or hypothermia
Ptosis and abnormal pupillary reflexe
What causes Wernike’s encephalopathy?
Alcoholism leads to malnutrition and deficiency in Vitamin B1 (Thiamine)
What effect does thiamin deficiency have on the brain in Wernike’s encephalopathy?
Causes brain lesions in the midbrain
How long do thiamine stores typically last?
1 month
How long does it take for Wernike’s encephalopathy to present?
Can present with symptoms within one week
How is Wernike’s encephalopathy treated?
Parenteral thiamine
What does Wernike’s encephalopathy often proceed?
Korsakoff’s syndrome
How does Korsakoff’s syndrome present?
Prominent impairment of recent and remote memory
Disordering of events
Impaired ability to learn new things
Marked confabulation (not always present)