substance exchange - mass transport Flashcards
What is the name given to haemoglobin that has bound to oxygen?
What is the name given to haemoglobin that has bound to oxygen?
oxyhaemoglobin
One haemoglobin molecule contains …. The haem groups contain …
One haemoglobin molecule contains four haem groups. The haem groups contain an iron ion which is what makes haemoglobin red.
Dissociation
Dissociation
When the red blood cells reach the tissues in the body (e.g. muscle cells), oxygen is released from the oxyhaemoglobin in a process called dissociation.
Haem groups
Each polypeptide chain in a haemoglobin molecule has …
A haem group is …
The haem groups contain an iron ion.
The iron ion is what …
Haem groups
Each polypeptide chain in a haemoglobin molecule has a haem group.
A haem group is a prosthetic group that is attached to the protein.
The haem groups contain an iron ion.
The iron ion is what makes haemoglobin red.
Affinity
Haemoglobin has a high ___ (attraction) for oxygen.
When red blood cells reach the lungs, …
When oxygen binds to haemoglobin, ___ is formed.
Affinity
Haemoglobin has a high affinity (attraction) for oxygen.
When red blood cells reach the lungs, oxygen diffuses into the red blood cells and binds to haemoglobin.
Four molecules of oxygen bind to one molecule of haemoglobin.
When oxygen binds to haemoglobin, oxyhaemoglobin is formed.
Partial pressure
Oxygen partial pressure (pO2) is …
Carbon dioxide partial pressure (pCO2) is …
pO2 is important in determining …
Partial pressure
Oxygen partial pressure (pO2) is the concentration of oxygen in the cells.
Carbon dioxide partial pressure (pCO2) is the concentration of carbon dioxide in the cells.
pO2 is important in determining whether oxygen binds to haemoglobin.
Affinity
pO2 determines …
If pO2 is high, haemoglobin ..
If pO2 is low, haemoglobin …
Affinity
pO2 determines the affinity of haemoglobin for oxygen.
If pO2 is high, haemoglobin has a high affinity for oxygen and oxygen binds to haemoglobin.
If pO2 is low, haemoglobin has a low affinity for oxygen and oxygen dissociates from haemoglobin.
Transport of oxygen
The effect of pO2 on the affinity of haemoglobin allows …
This allows …
Transport of oxygen
The effect of pO2 on the affinity of haemoglobin allows oxygen to be transported from the lungs (where there is lots of oxygen) to the respiring tissues (where oxygen is limited).
This allows oxygen to be transported to the cells where oxygen is needed most.
Animals living at high altitudes have haemoglobin which has ….
This is an advantage because …
___ also have haemoglobin with a high affinity for oxygen.
Animals living at high altitudes have haemoglobin which has a high affinity for oxygen.
This is an advantage because the air at higher altitudes has a much lower partial pressure than at sea level.
Birds also have haemoglobin with a high affinity for oxygen.
High metabolic rate
Animals with high metabolic rates have haemoglobin …
This allows …
High metabolic rate
Animals with high metabolic rates have haemoglobin that dissociates with oxygen very easily.
This allows oxygen to be quickly and easily supplied to the cells for use in respiration.
What is the impact on haemoglobin when the first molecule of oxygen binds?
What is the impact on haemoglobin when the first molecule of oxygen binds?
O2 BINDS MORE EASILY
Dissociation Curves
Dissociation Curves
The relationship between the percentage saturation of haemoglobin and oxygen partial pressure of the surrounding tissues can be shown in a dissociation curve.
Low pO2
When partial pressure is low, …
The percentage saturation of haemoglobin is low COZ ..
Low pO2
When partial pressure is low, haemoglobin has a low affinity for oxygen.
The percentage saturation of haemoglobin is low because oxygen dissociates from the haemoglobin.
Increasing pO2
As pO2 increases, …
When the first molecule of O2 binds to haemoglobin, ..
The change in shape allows …
The percentage saturation…
Increasing pO2
As pO2 increases, affinity of haemoglobin for oxygen increases slightly.
When the first molecule of O2 binds to haemoglobin, the protein undergoes a conformational change.
The change in shape allows the other O2 molecules to bind to haemoglobin more easily.
The percentage saturation of haemoglobin increases quickly.
Plateau in percentage saturation
As more molecules of O2 bind to haemoglobin, …
The percentage saturation of haemoglobin …
Plateau in percentage saturation
As more molecules of O2 bind to haemoglobin, it becomes more difficult for more O2 molecules to bind.
The percentage saturation of haemoglobin begins to plateau.
S-shaped curve
The increasing affinity of haemoglobin …
The S-shaped curve is called …
S-shaped curve
The increasing affinity of haemoglobin with increasing pO2 in this way creates an S-shaped curve.
The S-shaped curve is called the dissociation curve.
High pCO2
Respiring cells use … and produce …
The respiring cells have low ___ and high ___.
When pCO2 is high, …
High pCO2
Respiring cells use oxygen in respiration and produce carbon dioxide.
The respiring cells have low pO2 and high pCO2.
When pCO2 is high, the rate of oxygen dissociation increases.
Bohr effect
The increased dissociation of oxygen causes …
… means that oxygen will dissociate from haemoglobin at a lower pO2 than normal.
This is called …
Bohr effect
The increased dissociation of oxygen causes a shift in the oxyhaemoglobin dissociation curve to the right.
The shift in the dissociation curve means that oxygen will dissociate from haemoglobin at a lower pO2 than normal.
This is called the Bohr effect.
How does a high pCO2 impact haemoglobin affinity for oxygen?
How does a high pCO2 impact haemoglobin affinity for oxygen?
decreases affinity
The heart is the centre of …
Mammals have a double circulatory system. This means …
Deoxygenated blood is pumped to …
Oxygenated blood is pumped …
The heart is the centre of the circulatory system.
Mammals have a double circulatory system. This means blood flows through the heart twice in one circuit.
Deoxygenated blood is pumped to the lungs.
Oxygenated blood is pumped around the body.
Coronary arteries
The heart is a muscle that is constantly contracting and relaxing.
The heart muscle needs a constant supply of oxygen for ____.
The coronary arteries supply ….
Coronary arteries
The heart is a muscle that is constantly contracting and relaxing.
The heart muscle needs a constant supply of oxygen for respiration.
The coronary arteries supply blood to the heart.
Pulmonary artery & vein
… is pumped out of the heart to the lungs via the pulmonary artery.
Oxygen diffuses into …
Oxygenated blood flows …
Pulmonary artery & vein
Deoxygenated blood is pumped out of the heart to the lungs via the pulmonary artery.
Oxygen diffuses into the deoxygenated blood in the lungs and the blood becomes oxygenated.
Oxygenated blood flows into the heart from the lungs via the pulmonary vein.
Aorta & vena cava
Oxygenated blood is pumped out of the heart around the body via the aorta.
Blood in the aorta is very high pressure to ensure the blood can be pumped to all the tissues in the body.
Oxygen dissociates from the blood at respiring cells in the body and the blood becomes deoxygenated.
Deoxygenated blood flows into the heart from the body via the vena cava.
Aorta & vena cava
Oxygenated blood is pumped out of the heart around the body via the aorta.
Blood in the aorta is very high pressure to ensure the blood can be pumped to all the tissues in the body.
Oxygen dissociates from the blood at respiring cells in the body and the blood becomes deoxygenated.
Deoxygenated blood flows into the heart from the body via the vena cava.
Arteries Away
vEins rEturn
Arteries Away
vEins rEturn
flow of blood
flow of blood
the blood is going to move from the right atrium thru the right av valve and into the right ventricle
the its gonna move out thru the semilunar valve into the pulmonary artery (cos we’re moving away from the heart)
from the PA (PULMONARY ARTERY) we’re going to the lungs
in the lungs we pick up oxygen and were gonna return to the heart down the pulmonary vein
from there were gonna enter the left side of the heart
blood is gonna enter thru the left atrium thru the left av valve and into the left ventricle
and from there we r gonna pass thru that semilunar valve and into the aorta
and the aorta is gonna pump the blood right around the body where its gonna lose its oxygen and end up back at the vena cava
from there we go back into the right atrium and the cycle repeats
flow of blood order
flow of blood order
right atrium right ventricle pulmonary artery lungs pulmonary vein left atrium left ventricle aorta body vena cava
what is the point of valves
valves prevent back flow
whats the point of AV valves
whats the point of AV valves
AV valves prevent blood from flowing back into atria when ventricles contract
whats the point of semilunar valves
whats the point of semilunar valves
semilunar valves stop blood from flowing from arteries back into ventricles
blood wants to move from …
when a chamber contracts, …
so blood could either move onto the next part of the heart or backwards: …
blood wants to move from high pressure to low pressure
when a chamber contracts, the pressure increases
so blood could either move onto the next part of the heart or backwards: both r at low pressure
valves prevent back flow
Vena cava
Renal
artery
Pulmonary
vein
Aorta
Coronary
arteries
Vena
cava
The blood vessel that carries deoxygenated blood from the body into the heart.
Renal
artery
The blood vessel that oxygenated blood flows through to enter the kidneys.
Pulmonary
vein
The blood vessel that carries oxygenated blood from the lungs to the heart.
Aorta
The blood vessel that oxygenated blood flows out of the heart through and to the rest of the body.
Coronary
arteries
The blood vessels that supply blood to the heart.
the cardiac cycle
1) Atrial contraction
the cardiac cycle
1) Atrial contraction
Blood from the lungs flows into the left atrium and blood from the body flows into the right atrium simultaneously.
The atria contract, increasing the pressure in the atria.
The blood in the atria is forced into the ventricles.
The ventricles are relaxed and fill with blood.
the cardiac cycle
2) Ventricular contraction
the cardiac cycle
2) Ventricular contraction
The atria relax and the ventricles start to contract.
Contraction of the ventricles causes the pressure inside the ventricles to increase.
The pressure shuts the atrioventricular valves so that blood does not flow back into the atria.
The blood in the ventricles is forced out of the ventricles and out of the heart through the pulmonary artery or the aorta.
the cardiac cycle
3) Relaxation
the cardiac cycle
3) Relaxation
The blood in the pulmonary artery and the aorta is at high pressure. -The pressure shuts the semi-lunar valves so that blood does not flow back into the ventricles.
Both the ventricles and the atria relax and the atrioventricular valves reopen.
Blood flows into the ventricles and the atria from the pulmonary vein and vena cava.
the cardiac cycle
4) cycle repeats
the cardiac cycle
Right atrium
Deoxygenated blood flows into ..
The vein that pumps deoxygenated blood into the right atrium is called the ____
The right atrium is the first chamber that …
Right atrium
Deoxygenated blood flows into the right atrium from the body.
The vein that pumps deoxygenated blood into the right atrium is called the vena cava.
The right atrium is the first chamber that deoxygenated blood flows through.