Substance Abuse Terms Flashcards

1
Q

Sensitization definition

A

Increased response to a drug with repeated use

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2
Q

Sensitization shifts the dose response curve to the…

A

left

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3
Q

Withdrawal definition

A

Behaviors displayed by a user when drug use ends, usually opposite of the drug’s effect

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4
Q

Tolerance definition

A

State of adaptation in which exposure to a drug induces changes that results in a diminution of one or more of the drug’s effect over time

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5
Q

Tolerance shifts the dose-response curve to the…

A

right

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6
Q

Two types of tolerance

A

Metabolic (liver enzymes) and cellular (receptor downregulation)

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7
Q

Acute vs. protracted tolerance

A

Acute happens within a single administration

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8
Q

Cross-tolerance definition

A

Tolerance to one drug leads to tolerance of other drugs in the same drug class

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9
Q

Addiction definition

A

Primary, chronic, neurobiological disease, with genetic, psychosocial, and environmental factors influencing its development and manifestations

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10
Q

5 Cs of addiction

A

Chronicity
impaired Control of drug use,
Compulsive use
Continued use despite harm
Craving

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11
Q

Drug abuse definition

A

Maladaptive pattern of substance abuse characterized by repeated adverse consequences related to the repeated use of the substance

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12
Q

Dependence definition

A

Body adapts to presence of the drug and needs it on board to maintain homeostasis. Specific withdrawal symptoms can be produced by abrupt cessation, rapid dose reduction, decreasing blood level of a drug and/or administration of an antagonist

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13
Q

Opiate agonist definiton

A

Drugs that activate opiate receptors on neurons

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14
Q

Opiate antagonist definition

A

Opiates that bind to opiate receptors but block them rather than activate them

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15
Q

Partial agonist definition

A

Drugs that bind to receptors but not to the same degree as full agonists

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