PK/PD of ETOH Flashcards

1
Q

Alcohol has ____-order absorption in the GI system

A

first

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2
Q

What delays alcohol absorption?

A

Lipids and proteins- leads to a lower peak and AUC

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3
Q

What enhances alcohol absorption?

A

Water and carbonation- leads to a higher peak and AUC

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4
Q

Where is alcohol primarily absorbed

A

Small intestine

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5
Q

Gastric bypass procedures ____ rate of alcohol absorption

A

Increase, implications of a zero-order metabolism

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6
Q

Vd of ethanol is equal to what?

A

Total body water

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7
Q

What populations have a smaller Vd for alcohol and why?

A

Women and obese patients, because they have more adipose tissue (which alcohol distributes poorly into!)

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8
Q

Where does alcohol rapidly cross and why?

A

BBB because it’s a small molecule

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9
Q

What kind of metabolism does alcohol have?

A

Capacity-limited/Michaelis-Menten

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10
Q

Alcohol has ____-order metabolism via alcohol dehydrogenase

A

zero

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11
Q

A small amount of alcohol is metabolized by what CYP enzyme?

A

CYP2E1, but it doesn’t really do much to speed the CL up

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12
Q

Gender differences in alcohol PK in women

A

Ethanol distributes to total body water and lean mass and women have a smaller Vd/kg

Women have less efficient pre-hepatic alcohol dehydrogenase so they have a greater bioavailability

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