Substance abuse

Question 1

What is dependence syndrome?

Answer 1

Desire/compulsion to take substance
Difficulty in controlling substance use
Physiological withdrawal state
Tolerance
Neglect of alternative pleasures/interests
Continued use despite negative consequences

Question 2

What is buprenorphine?

Answer 2

Partial agonist of mu receptors

Treats addiction

Question 3

What is naltrexone?

Answer 3

Opioid antagonist

Block euphoria - used to prevent relapse

Question 4

What is acamprosate?

Answer 4

Restores balance of neutrotransmitters in the brain in alcohol withdrawal

Question 5

What is disulfiram?

Answer 5

Makes patient sick if they drink alcohol

Question 6

What are the signs of Wernicke’s encephalopathy?

Answer 6

Confusion
Wide based gait ataxia
Ophthalmoplegia

Question 7

What is the treatment of Wernicke’s encephalopathy?

Answer 7

Pabrinex (thiamine - B1)

Benzos

Question 8

How is opioid abuse managed?

Answer 8

Methadone

Question 9

What drug is used to treat acute opioid misuse?

Answer 9

Naloxone

Question 10

What drug is used to treat benzo overdose?

Answer 10

Flumazenil

Question 11

What drug is used to treat paracetamol overdose?

Answer 11

Activated charcoal - within 1hr

Acetyl-cysteine