Substance Abuse Flashcards
**Give what for alcohol withdrawal?
Benzo (GABA agonist to decr seizure), anticonvulsant (reduce SZ risk), thiamine supplememntation
disulfram (Alc Dehydr inhibitor)
naltrexone (opioid antag)
acamprosate (check renal fxn bc cleared renally)
- all are given for what?
for alcohol (to stop from drinking)
naltrexone (opioid antag)
buprenorphine (PARTIAL mu agon)
methadone (mu agon)
- all are given for what?
which has ceiling effect?
opioid use disorder treatment
buprenorphine has ceiling effect
tobacco ad drug interactions
CYP1A2 inhibitor (i.e. olanzapine)
what category is MDMA?
a hallucinogen
neuroadaptation -
MDMA
MDMA - 5HT2 receptor agonists
nystagmus
PCP
pinpoint pupils
opioids
neuroadaptation of ____ drug:
opiate receptor effects. allosteric modulator of glutamate NMDA receptor
PCP
neuroadaptation of ____ drug:
increased DA and decreased NE
opioids
neuroadaptation of ____ drug:
it mainly prevents reuptake of DA
cocaine
neuroadaptation of ____ drug:
inhibit reuptake of DA, NE, SE - greatest effect on DA
amphetamines
neuroadaptation of ____ drug:
nAChR on DA neurons in VTA release DA in NAc
tobacco
neuroadaptation of ____ drug:
5HT, DA, NE but predominantly 5HT2 receptor agonists
MDMA
neuroadaptation of ____ drug:
CB1, CB2 cannabinoid receptors in brain/body
-coupled G protein and AC to CA channel inhibiting Ca influx
cannabis
