Demenita Flashcards
1
Q
Overall MOA of acetylcholinesterase inhibitors
A
decrease AChE levels, thus increasing ACh levels throughout hte body
2
Q
tertiary/uncharged AChE inhibitors (5)
Do they cross BBB?
A
donepezil galantamine physostigmine rivastigmine tacrine
Yes, do cross BBB = toxic.
3
Q
quaternary/charged AChE inhibitors (5)
Do they cross BBB?
A
ambenonium echothiophanate edrophonium neostigmine pyridostigmine
No, do not cross BBB = safer
4
Q
Which AChE inhibitors are reversible?
A
the carbamic acid esters - noncovalent
ambenoium, neostigmine, physostigmine, pyridostigmine
5
Q
Antidote for overexposure to organophosphate
A
pralidoxime and benzodiazepine - give pralidoxime BEFORE aging has occurred.
