Subatomic Processes Flashcards

1
Q

What makes up an atom?

A

Protons (+ charge) neutrons (neutral charge) electrons (negative charge).
Protons and neutrons are in the nucleus and are made up of sub atomic particles called quarks.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How do electrons behave

A

The arrangement of electrons in orbitals determines how an atom will react with another atom. When e- drops an energy level this energy is relased as a photon of light.
This photon has a specific energy and wavelength for each species of atom known as a spectral line.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Atomic wt v atomic number

What is an isotope

A

Atomic number is number of protons in nucleus. Atomic weight is number of protons and neutrons.

Isotopes have same atomic number but different atomic weight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q
  1. Covalent bonds
  2. Ionic bonds
A
  1. Share electrons
  2. Transfer electrons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q
  1. Hydrogen bonding
  2. Hydrophobic bonding
  3. Van der walls forced
A
  1. Hydrogen atom covalently charged to negatively charged atom (dipolar force).
  2. Exclude water molecules between two non polar molecules.
  3. Attractions between electron clouds of neighbouring atoms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Electrostatic binding

A

Binding of oppositely charged MOLECULES. Ie drug to protein binding.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Hydroxyl
Amino
Carboxyl
Methyl ether
Benzene
Phenol

A

OH
NH2
COOH2
OCH3
Six carbon atoms in a ring
Benzene ring with hydroxyl group (add two carbon chains to make propofol!)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is isomerism

A

Molecules composed of the same number of atoms in the same proportions but with variations in the arrangement of the atoms.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is tautomerism

Give an example.

A

Migration of a hydrogen atom and switching single and adjacent double bond.

Midazolam open ring form is water soluble at lower pH
At physiological higher pH is closed ring and lipid soluble to cross CNS.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Aromatic isomer

Give an example.

A

Chemical group positioned on a different part of benzene ring.

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Stereoisomer definition.

Give two types of stereoisomer.

A

Same number of molecules in same order but different 3D arrangement.

Optical and geometric.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Chiral centre

A

Carbon atoms attached to 4 different chemical species

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Racemic mixture

A

Equal enantiomers of left (S) and right (R) configurations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Geometric conformer isomersim

Give an example.

A

Rotation about one or more single bonds.

Hindrance of rotation around bond - vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the venturi principle
Example

A

When fluid flows through a tube with a constriction in it, the kinetic energy energy increases. Due to the conservation of energy this means that there is a fall in potential energy and a drop in pressure. This can be used to entrainment a second fluid.
Nebuliser

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What happens if a compressed gas expands adiabatically?
Example
Which law is this?

A

It will cool because the energy required to over come the van der walls forces can only come from the molecules themselves there is no heat transfer from surroundings.
Cryoprobe
First

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

First, second and third law of thermodynamics

A
  1. Energy is not created or destroyed
  2. Law of increased entropy (unavailable entropy)
  3. As a system approached 0 Kelvin all processes cease and the entropy is minimal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is pH

A

Negative logarithm to base 10 of hydrogen ions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is a strong ion
Give 4 examples

A

Compound which completely dissociates in water
K, Ca, Mg, LACTATE

20
Q

What is a weak ion
Example
What is K

A

Partially dissociated
Carbonic acid
Dissociation constant - rate of forward reaction into ions

21
Q

What is dissociation constant equation

A

K = [H+] x [HCO3-] / [H2CO3]

22
Q

What is a strong acid
Weak acid
Example of strong

A

Acid completely dissociated in solution
Does not completely dissociate
Lactic acid

23
Q

What is a strong or weak base
Example of weak base

A

Compound with does or does not dissociate into its hydroxyl ion and cation

Ammonia, LA

24
Q

What is pKa

A

The pH at which a compound and its dissociated ions exist in equilibrium.

Acids ionise above their pKa
Bases ionise below their pKa

25
What is a buffer, give 3 examples
Solution able to resist changes in H and OH Bicarbonate, phosphate, proteins
26
How does temperature affect pH
Increases disassociation and hydrogen ions conc therefore lowers pH
27
How does EM radiation originate
Generated by oscillations of charged particles (either protons or electrons) and attract opposite charge on electrical field lines
28
Frequency definition Frequency equation Frequency units
Number of wavelengths passing a fixed point in 1 second Lamba (wavelength) = f x c (speed of light 2.98x10⁸) Hertz
29
Energy of EM radiation equation
E = v (frequency) x h (Plancks constant)
30
How does EM waveforms exist
As an oscillating sine wave travelling at the speed of light in longitudinal and transverse fields. Longer wavelengths ie radio waves exist as waves and shorter ie gamma have more particle properties
31
How does a side stream analyser work and advantages (3)/ disadvantages (2)
Removes 150ml/ min through sample line, water removed and remaining gas sent to analyser Lightweight, robust, allows multiple gas sampling Lag time, can be affected by O2, N2O and water vapour
32
Reasons sats probe may be unreliable? (Three categories)
1. Pulsatile component - AF, Met and COHb, surgical dyes, vasoconstriction 2. Non pulsatile component - external lighting interference, nail varnish 3. Electrical interference - diathermy
33
What is total internal reflection
Angle of incidence is greater than the critical angle required that would refract the light
34
How does fibre optical laryngoscope work
Two layers of glass, outer layer has a lower index of refraction to ensure total internal reflection
35
Wavelength of maximal absorption of CO2
4.3 micro metres
36
Definition of laser
Light amplification of stimulated emission of radiation
37
Three properties of laser
1. Monochromatic (one specific wavelength) 2. Coherent (in phase) 3. Collimated (highly directional)
38
What is stimulated emission
When energy provided to electrons to reach higher state this acts as an energy source to neighbouring atoms to achieve the same state. When it relaxes it releases two in phase photons of light.
39
How do lasers work
A lasing medium is pumped with energy to create stimulated emission. Mirrors allow amplification to achieve population inversion and a small gap let's out light energy.
40
Examples of 2 infrared lasers
1. CO2 - 10600nm far IR 1mm tissue surface Bloodless cutting and vaporisation 2. Nd:YAG - 1064nm near IR 3-5mm depth Absorbed by Hb, melanin and water
41
Example of visible light laser
Argon - 500nm blue green 2mm Coagulation
42
Laser classification
1 low power 2 < 1mw 3 < 500mw hazardous if directly viewed 4 >500mw
43
Name two types of isomerism with examples
Constitutional (structural) - Identical chemical formula, order of atomic bonds differ. Enflurane and isoflurane. Stereoisomers - same atoms same order different 3D arrangement.
44
Definition of optical isomers Give two examples
Non superimposable mirror image (left/ right) (R/S) 1. S-ketamine (less psych s/e) 2. Levo-bupivicaine (less cardio toxic)
45
Cis-trans geometric isomerism definition Give an example
Variable molecule on same or opposite side of double bond Cisatracurium (more CVS stable)
46
pH equation
pH = pKa log10 ([HCO3-] / [CO2])
47
Risks of lasers
1. Flammable 2. Laser tracheal tubes, balloon with saline 3. Reflection if light therefore use matt black instruments 4. Visual - goggles, door screens 5. Personell - specific person in theatre responsible