Study Study guide wink wink

Question 1

Cyclophosphamide

Answer 1

bladder toxicity
drink 2L per day
use emetic

Question 2

Cisplatin

Answer 2

extravasation!
hard on vessels, IV access
sodium __________

Question 3

Antimetabolite

Answer 3

decreases folic acid
teratogenic - methotrexate

Question 4

Tamoxifen

Answer 4

double glove
decrease estrogen
bone density

Question 5

cytoprotectants

Answer 5

prevent side effects of chemo

Question 6

Epoetin alpha

Answer 6

increase RBC

Question 7

Filgrastim

Answer 7

WBC

Question 8

Leukovorin

Answer 8

folic acid (methotrexate)

Question 9

Oprelvkin

Answer 9

increase platelet

Question 10

Tumor Lysis Syndrome

Answer 10

HYPER Kalem Calc Uric Phos
HYPO Calcium Mag

TREAT WITH FLUID

Question 11

Antibiotics - general principles

Answer 11

Start broad (not for long r/t superinfection risk)
Take ALL doses (r/t residual bacteria)

Question 12

Superinfection

Answer 12

kills normal flora

Question 13

Opportunistic

Answer 13

immunocompromised (HIV)

Question 14

Aminoglycosides

Answer 14

GNATS
Gentamycin - oto/nephrotoxic
Cardiac edema, peripheral neuropathy, herpes
NARROW TI (trough and peak)
CANNOT GIVE PENICILLIN
(one hour pre/post)

Question 15

Cephalosporin

Answer 15

AE: bleeds, CBC, anti-coagulated patients

Question 16

Aztreonam

Answer 16

Dilator –> mucolytic –> Az

Question 17

Penicillin

Answer 17

Hypersensitivity
NO cyclo/cephalosporin
Interstital nephritis!! (inflammed tubules)

PEN G ACCIDENTALLY GIVEN CAN CAUSE CARDIAC ARREST

Question 18

Fluoroquinolone

Answer 18

(Flozins)
Tendinitis (tendon rupture)
Weakness
Hyper/hypoglycemia
Photosensitivity
QT prolongation

Question 19

Macrolides

Answer 19

Eyrthromycin, azithromycin
Hepatotoxic, pseudo colitis, QT prolong

INTERACTS with warfarin/dig

Question 20

Fluconazole + Diltiazem

Answer 20

CARDIAC DEATH

Question 21

Clindamycin

Answer 21

FATAL PSEUDOMEMBRANOUS COLITIS

Question 22

Lipoglycopeptide

Answer 22

Vancomycin
Nephrotoxic (amino +vanc)
Only certain doses peripheral
NARROW TI- trough before 4th dose
RED MAN SYNDROME

Question 23

Linezolid

Answer 23

Not long term (bone marrow suppression)
Cannot give with antidepressants (r/t serotonin syndrome)

Question 24

Chloramphenicol

Answer 24

blood dyscrasia (aplastic anemia PERMENANT) (bleeds)

Question 25

Daptomycin

Answer 25

NO STATIN

Question 26

Sulfonamides

Answer 26

Hypersensitivity Photosensitivity Steven Johnson Syndrome

Question 27

Tetracycline

Answer 27

EMPTY STOMACH W WATER UPRIGHT FOR 30m (ESOPHAGITIS) expired --> renal failure teeth discoloration under 8yr harms bone growth photosensitivy

Question 28

Urinary antiseptics

Answer 28

Phenazopyridine orange urine - no UA longer than two days renal failure (JAUNDICE SERIOUSLY)

Question 29

TB meds

Answer 29

Rifampin - orange +stains INH - liver toxic - neuropathy B6 Pyrazinamide - hyperuricemia (finish GOUT) Ethambutol - optic neuritis (red/green)

Question 30

Herpes

Answer 30

FAV Famciclovir Aciclovir Valacyclvoir thrombocytopenic purpura (decrease platelet causes bleeding) (red tiny dots)

Question 31

Cytomegalovirus

Answer 31

Ganciclovir bone marrow supressant birth defects - HCG pre/post

Question 32

Oseltamivir

Answer 32

take within 48hr within symptoms of flu

Question 33

RSV

Answer 33

Ribavirin Inhaled - extremely teratogenic (NO PREGGO IN ROOM)

Question 34

Hepatitis B/C

Answer 34

pancreatitis

Question 35

HIV drugs

Answer 35

cannot miss a dose!

Question 36

Antifungals

Answer 36

Amphotericin B (BIG INFECTION cardiac death only compatible with dextrose NO AMINOGLYCO hard on vein (phleb risk) Lipid form in renal patient

Question 37

Glycoizil

Answer 37

hepatic necrosis (liver toxic(

Question 38

Echinocandin

Answer 38

Assess duration binds to albumin

Question 39

Terbinafine

Answer 39

hepatotoxicity

Question 40

Malaria

Answer 40

QUINN take drug pre/post exposure

Question 41

amebicides

Answer 41

hard on liver (NO ALC) flush,sweat

Question 42

Lindaine

Answer 42

CNS --> seizure precaution