Studies

Question 1

Macular photo coagulation study:

AMD or OHS with extrafoveal CNV, Juxtafoveal CNV, subfoveal CNV, recurrent CNV

Answer 1

Argon tx vs observation
Extrafoveal CNV decreased risk of 6 line lose with argon laser (62 vs 48% in control vs treated)
Juxtafoveal with 61 vs 52% with less than 6 line vision lose

Question 2

TAP and VIP

Answer 2

Tap. For classic CNV

VIP for occult CNV

Patients that were treated lost 1.5 lines compared to 3 lines in control

Question 3

Vision

Answer 3

Pegatinib given at 1.5 mg and 3 mg
Vision decreased the first year and stabilized in the second year.
Established an appropriate technique for repeated injections

Question 4

Leucentis
Eylea
Avastin

Answer 4

Leucentis Binds all isoforms of VEGF

Eylea synthetic Fc fragment that binds both
Has 50 percent higher affinity

Full antibody

Question 5

Anchor and marina

Answer 5

95 % with stabilization of vision
75% with gain of vision

Marina. 21.5 letter increase and 3.5 line increase

Question 6

Pier

Answer 6

Leucentis four months in a row the q 3 months.

Gained vision initially then lost back to baseline

Question 7

EVS (endophthalmitis Vitrectomy study)

Answer 7

for acute post-op endophthalmiitis with VA of LP or better
Underwent Tap and Injection, subconj abx and steroids, topical and oral steroids, and randomized to vitrectomy or tap, and IV abx or not.
IV abx not beneficial
Vitrectomy significant benefit only for patients with LP or worse vision.