Stroke Flashcards

1
Q

What is the definition of a stroke?

A

Clinical syndrome consisting of rapidly developing clinical signs of focal disturbance of cerebral function lasting more than 24 hours or leading to death with no apparent cause other than a vascular origin

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2
Q

What is the onset of stroke like?

A

Sudden

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3
Q

What might carotid territory strokes look like?

A

Usually unilateral
Weakness of face, leg, arm
Amaurosis fugax
Impaired language

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4
Q

What might a posterior circulation stroke look like?

A
Dysarthria
Dysphasia
Diplopia
Dizziness
Ataxia
Diplegia
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5
Q

What is an ischaemic stroke?

A

Interruption of cerebral blood supply

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6
Q

What might cause and ischaemic stroke?

A

Embolism
Thrombosis
Systemic hypoperfusion

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7
Q

What is the oxford classification of strokes?

A

Anterior circulation infarct - partial/total
Posterior circulation infarct
Lacunar infarction

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8
Q

What is an anterior circulation infarction and what are the symptoms?

A

Anterior and middle cerebral artery stroke
Contralateral weakness
Contralateral sensory loss/sensory inattention
Dysarthria
Dysphasia (receptive/expressive)
Homonymous hemianopia/visual inattention
Higher cortical dysfunction

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9
Q

What are the symptoms of a posterior circulation infarction?

A

CN palsies and contralateral motor/sensory deficit
Conjugate eye movement
Cerebellar dysfunction eg vertigo, nystagmus, ataxia, dysarthria
Isolated homonymous hemianopia
Bilateral events can cause reduced GCS

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10
Q

What is a lacunar infart?

A

Occlusion of deep penetrating arteries
Affects a small volume of subcortical white matter - no cortical features
Underlying process often small vessel disease

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11
Q

What are the lacunar syndromes?

A
Pure motor hemiparesis
Ataxic hemiparesis
Clumsy hand and dysarthria
Pure hemisensory
Mixed sensorimotor
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12
Q

What is the Bamford stroke classification of a total anterior circulation stroke?

A

All 3 of the following:

  • Unilateral weakness (and/or sensory deficit) of the face, arm, and leg
  • Homonymous hemianopia
  • Higher cerebral dysfunction (dysphasia, visuospatial disorder)
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13
Q

What is the Bamford stroke classification of a partial anterior circulation stroke?

A

2 of the following

  • Unilateral weakness (and/or sensory deficit) of the face, arm, and leg
  • Homonymous hemianopia
  • Higher cerebral dysfunction (dysphasia, visuospatial disorder)
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14
Q

What is the Bamford stroke classification for lacunar syndrome?

A

1 of the following

  • Pure sensory stroke
  • Pure motor stroke
  • Sensori-motor stroke
  • Ataxia hemiparesis
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15
Q

What is the Bamford stroke classification of a posterior circulation stroke?

A

1 of the following

  • CN palsy and contralateral motor/sensory deficit
  • Bilateral motor/sensory deficit
  • Conjugate eye movement disorder (eg gaze palsy)
  • Cerebellar dysfunction (ataxia, nystagmus, vertigo)
  • Isolated homonymous hemianopia or cortical blindness
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16
Q

How do you assess a stroke in A&E?

A

ABCDE assessment + bloods, BM
Brief Hx and examination (time of onset, RF, CI to thrombolysis)
BP
NIHSS - grade severity of stroke

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17
Q

What investigations should you do for a stroke?

A

Urgent CT head +/- CT angiography

18
Q

How can you treat a stroke?

A

Thrombolysis +/- mechanical thrombectomy if indicated
OR
Aspirin 300mg

19
Q

What should you do after someone has had a stroke?

A

Investigate the cause
Screen and prevent complications (dehydration, aspiration, VTEs, pressure sores, infection, depression)
Establish secondary prevention (lifestyle, medication, surgery)
Rehabilitation (physiotherapy, occupational therapy, SALT)

20
Q

What is the medication for secondary prevention?

A
Aspirin 75mg for 3 weeks
Clopidogrel 75mg for life
Statin
BP medication
Ect
21
Q

What surgery can be done for secondary prevention?

A

Stents in carotids

Carotid surgery

22
Q

What is the NIHSS?

A

National Institutes of Health Stroke Scale

Grades and tracks severity of stroke

23
Q

What does the NIHSS look at?

A
Level of consciousness
Best gaze
Visual symptoms
Facial palsy severity
Motor arm and leg symptoms
Limb ataxia severity
Sensory loss severity
Best language
Dysarthria severity
Extinction and inattention
24
Q

What are the pros of doing a CT in an acute stroke?

A

Quick
Readily available 24/7
Sensitive for haemorrhage
May see hyperdense vessels

25
What are the cons of doing a CT in acute stroke?
Cannot usually diagnose an infarct in acute phase Less sensitive than MRI for picking up other abnormalities eg demyelination, mass lesions, microhaemorrahges and for lacunar and PCI
26
What is thrombolysis?
Breaking down an acute clot
27
What do you give in thrombolysis?
Alteplase - IV - tissue plasminogen activator | 0.9mg/kg
28
When can you give thrombolysis?
Within 4.5 hours of symptom onset
29
What are the CI of thrombolysis?
Symptoms only minor or rapidly improving Haemorrhage on imaging Suspected SAH Active bleed from any site Recent GI/urinary tract haemorrhage within 21 days Platelet count < 100,000/mm3 Recent treatment with heparin and APTT above normal Recent treatment with warfarin and INR elevated Recent major surgery or trauma within last 14 days Recent post MI pericarditis Neurosurgery, serious head trauma or previous stroke within 3 months Hx of intracranial haemorrhage ever Known arteriovenous malformation or aneurysm Recent arterial puncture at non-compressible site Recent LP BP > 185/110 Abnormal BM Suspected/known pregnancy Active pancreatitis Epileptic seizure at stroke onset
30
What care needs to be given post-thrombolysis?
More aggressive BP monitoring Vigilance for complications 24 hr CT head
31
What is a mechanical thrombectomy?
Mechanical recanalisation of culprit vessel Proximal stenosis Can be used with thrombolysis
32
What is the time frame for anterior circulation stroke treatment with thrombectomy?
6 hours
33
What bloods should you do in stroke?
``` FBC ESR U&E Lipid profile LFT CRP Clotting screen Glucose and HbA1c ```
34
What investigations should you do after a stroke?
``` Bloods ECG Carotid doppler USS Echo MRI ```
35
What extra investigations should you do in a young person?
Bloods - HIV and vasculitis screen, thrombophilia screen, homocysteine Cardiac investigations - 7 day holter recorder, implantable loop recorder, transcranial doppler, transoesophageal echo Vascular imaging - CT/MRI angiography
36
What is a watershed stroke?
A stroke occurring due to lack of blood supply in areas that are supplied by 2 arteries
37
Who is involved in stroke care from the MDT?
``` Nurses Physio OT SALT Dieticians Orthoptics ```
38
What lifestyle changes can be made following a stroke?
``` Smoking cessation Drug and alcohol cessation Dietary modifications Exercise Driving advice ```
39
What medical treatment can be given post-stroke?
``` VTE assessment Hydration NG feeding +/- PEG Spasticity - physio/botox Monitor for infection Antiplatelets Anticoags Hypertension treatment Statins ```
40
What are the 5 aspects in the management of haemorrhagic strokes?
ABCDE BP Bleeding tendency (coagulopathy/low platelets/medication related) Underlying malformation - tumour aneurysm, amyloid angiopathy, AV malformation, cavernoma Need for neurosurgery - useful for superficial clots, CSF obstruction causes hydrocephalus, posterior fossa decompression
41
What can reverse anticoagulation?
Warfarin - beriplex and vit K Heparin - protamine LMWH - protamine (only partially)
42
What can mimic stroke?
``` Seizures Tumours/abscess Migraine Metabolic - hypoglycaemia, hyponatraemia Functional Spinal cord/peripheral nerve/cranial nerve ```