Stroke

Question 0

What three factors can cause occlusion in stroke?

Answer 0

Thrombosis
Embolism
Atherosclerosis

Question 1

What are the 2 main mechanisms causing stroke?

Answer 1

Occlusion

Haemorrhage

Question 2

Which 3 conditions related to stroke share similar aetiology?

Answer 2

1) Transient Ischaemic Attack (TIA)
2) Perinatal ischaemia
3) Head Trauma

Question 3

Which artery is commonly affected in stroke?

Answer 3

MCA

Question 4

Which drugs are used in front-line stroke treatment?

Answer 4

Recombinant tissue plasminogen activators (r-tPAs)

Question 5

What is an example of an r-tPA?

Answer 5

Alteplase

Question 6

What is the action of alteplase?

Answer 6

Converts plasminogen to plasmin; plasmin cleaves fibrin

Question 7

What is the time constraint on use of r-tPA?

Answer 7

Before 4.5hrs after the stroke

Question 8

What is an alternative drug to alteplase in clinical trial?

Answer 8

Desmoteplase

Question 9

How is desmoteplase more effective than alteplase?

Answer 9

Better fibrin selectivity
Less effect BBB
May extend use up to 9hrs after stroke

Question 10

Role of hypothermia in animal models?

Answer 10

Reduce stroke damage

May also reduce side effect r-tPAs

Question 11

Name 3 egs drugs used as preventative measures

Answer 11

Statins
Aspirin
ACE inhibitors