Depression Flashcards

0
Q

Three groups of monoamine reuptake inhibitors?

A

1) Tricyclic antidepressants
2) selective serotonin reuptake inhibitors
3) serotonin and noradrenaline reuptake inhibitors

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1
Q

What are the 3 broad groups of drugs in treatment depression?

A

1) inhibitors monamine uptake
2) MAO inhibitors
3) atypicals

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2
Q

What are the most commonly prescribed antidepressants?

A

SSRIs

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3
Q

For which grade of depression are SSRIs most effective?

A

Moderate depression

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4
Q

What are side effects SSRIs?

A

Nausea
Insomnia
Sexual dysfunction

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5
Q

Which antidepressants have been developed more recently?

A

SNRIs

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6
Q

Examples of SNRIs?

A

Venlafaxine

Duloextine

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7
Q

For which ntmitter do SNRIs show greater selectivity?

A

5-HT

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8
Q

Examples of MAOIs?

A

Tranylcypromine
Phenelzine
Iproniazid

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9
Q

Action of MAOIs reversible or irreversible?

A

Irreversible

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10
Q

What is the action of bupropion as an atypical antidepressant?

A

DAT, in addition to NET and nicotinic receptor antagonism

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11
Q

Apart from drug treatment, what else may be effective?

A

Electroconvulsive therapy (ECT)

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12
Q

When is ECT used?

A

Severe major depression where other treatments have failed

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13
Q

Which antidepressants should not be combined?

A

SSRIs and MAOIs

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14
Q

What was the first antidepressant to be marketed and how does it act?

A

Iproniazid; non-selective MAO inhibitor

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