Depression Flashcards
Three groups of monoamine reuptake inhibitors?
1) Tricyclic antidepressants
2) selective serotonin reuptake inhibitors
3) serotonin and noradrenaline reuptake inhibitors
What are the 3 broad groups of drugs in treatment depression?
1) inhibitors monamine uptake
2) MAO inhibitors
3) atypicals
What are the most commonly prescribed antidepressants?
SSRIs
For which grade of depression are SSRIs most effective?
Moderate depression
What are side effects SSRIs?
Nausea
Insomnia
Sexual dysfunction
Which antidepressants have been developed more recently?
SNRIs
Examples of SNRIs?
Venlafaxine
Duloextine
For which ntmitter do SNRIs show greater selectivity?
5-HT
Examples of MAOIs?
Tranylcypromine
Phenelzine
Iproniazid
Action of MAOIs reversible or irreversible?
Irreversible
What is the action of bupropion as an atypical antidepressant?
DAT, in addition to NET and nicotinic receptor antagonism
Apart from drug treatment, what else may be effective?
Electroconvulsive therapy (ECT)
When is ECT used?
Severe major depression where other treatments have failed
Which antidepressants should not be combined?
SSRIs and MAOIs
What was the first antidepressant to be marketed and how does it act?
Iproniazid; non-selective MAO inhibitor