Stroke Flashcards

1
Q

Blood vessels that carry blood to the brain from the heart are called ()

A

arteries

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2
Q

A () occurs when one of these arteries to the brain is either blocked or bursts. As a result, part of the brain does not get the blood it needs, so it starts to die.

A

stroke

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3
Q
  • accounts for about 87 percent of all strokes
  • occurs when a blood clot, or thrombus, forms that blocks blood flow to part of the brain
A

Ischemic stroke

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4
Q

If a blood clot forms somewhere in the body and breaks off to become free-floating, it is called an ()

A

embolus

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5
Q

how does an embolus cause ischemic stroke

A

it can free float its way to the brain and block blood flow

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6
Q
  • occurs when a blood vessel on the brain’s surface ruptures and fills the space between the brain and skull with blood
  • or when a defective artery in the brain bursts and fills the surrounding tissue with blood
A

Hemorrhagic stroke

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7
Q
  • Caused by different things but is usually caused by a burst aneurysm.
  • A blood vessel bursts near the surface of the brain and blood leaks
    into the space between the brain and the skull.
  • Blood that collects in this space puts pressure on brain tissue and causes blood vessels to spasm.
A

subarachnoid hemorrhage

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8
Q
  • Caused when a burst blood vessel bleeds into brain tissue.
  • The bleeding causes brain cells to die and the part of the brain that is affected stops working correctly.
A

intracerebral hemorrhage

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9
Q

A dye is injected into the blood vessels that lead to the brain. The dye will show up on the x-ray and help locate blocked, narrowed or damaged blood vessels in the brain.

A

arteriogram

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10
Q

If an artery in the brain or one that goes to the brain is blocked for a short time, blood flow slows down or stops. This can cause a (1), sometimes called a (2).

A
  1. transient ischemic attack
  2. mini-stroke
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11
Q

examples of major “sudden” symptoms of transient ischemic attack

A

1) Numbness, weakness or paralysis of the face, arm or leg, usually on one side of the body
2) Loss of vision in one or both eyes or double vision
3) Trouble speaking or difficulty understanding others
4) Loss of balance or coordination
5) Severe headache with no known cause

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12
Q

When a TIA happens, the artery either becomes (1) or (2) and blood flow is normal. Symptoms last for a short time and then disappear. A TIA is a serious warning that you might have a stroke.

A
  1. unblocked after a short time
  2. a new path opens up
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13
Q

A stroke on the left side of the brain affects the right side of the body and you may experience some of the following:

A
  • Speech and language problems
  • Inability to read, write and learn new information
  • Impaired ability to do math or to organize, reason and analyze things
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14
Q

A stroke on the right side of the brain affects the left side of the body and you may experience some of following:

A
  • Problems with depth perception or directions, such as up or down, and front and back
  • Inability to be creative, such as painting a picture, or to appreciate art and music
  • Failure to recognize the emotion in someone’s voice
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15
Q

things to look out for when spotting a stroke

A
  1. face drooping
  2. arm weakness
  3. ## speech difficulty
  4. trouble walking
  5. trouble seeing with one or both eyes
  6. severe headache with no known cause
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16
Q

treatment for ischemic stroke or TIA

  • (): breaks up the blood clots that block blood flow to the brain. - Must be given within 3 hours after stroke symptoms start
  • The sooner treatment begins, the better your chances of recovery.
A

tissue plasminogen activator (tPA)

17
Q

treatment for ischemic stroke or TIA

  • If you cannot have tPA, (), such as aspirin or clopidogrel can be used
  • Helps stop blood clots from forming or getting larger.
  • The main side effect of these medicines is bleeding.
A

anticoagulant or blood-thinning medicine

18
Q

treatment for ischemic stroke or TIA

procedure to open up blocked arteries and restore blood flow to the brain

A

thrombectomy

19
Q

Treating a hemorrhagic stroke

main goal of medicines to be taken in case of hemorrhagic stroke

A
  • lower BP
  • stop blood-thining that may have led to bleeding
20
Q

Treating a hemorrhagic stroke

medical procedures for hemorrhagic stroke

A
  1. aneurysm clipping
  2. coil embolization
  3. draining excess fluid
21
Q

4 main ideas in pathophysiology of brain damage due to stroke

A

1) Excitotoxicity
2) Cell death signaling
3) Neuroinflammation & BBB breakdown
4) Oxidative stress & mitochondrial dysfunction

22
Q

examples of research models for ischemic stroke

A
  1. middle cerebral artery occlusion (MCAO)
  2. endothelin 1-induced constriction of arteries and veins
23
Q

research models for ischemic stroke

(): surgically dissected and subsequently permanently occluded

A

Permanent transcranial MCAO

24
Q

research models for ischemic stroke

types of MCAO

A
  1. endovascular filament MCAO
  2. clip MCAO
  3. thrombemolic MCAO
  4. Permanent transcranial MCAO
25
Q

research models for ischemic stroke

Thrombembolic MCAO: by injecting particles like ()

A

blood clots