Stroke Flashcards
How many people a year have a stroke?
~152000 a year
What percentage of stroke sufferers have good recovery?
1/3
What is the oxygen consumption of the brain?
20% of the whole body
How long before brain shuts down after blood supply has been cut off?
3-6 minutes neurons start dying
After 15 minutes pts brain dead
How is blood supplied to the brain
arch of aorta
common carotid artery
internal carotid artery
vertebral artery
circle of Willis formed through these arteries
what are the key arteries in the brain?
Anterior cerebral artery (ACA)
Middle cerebral artery (MCA)
Posterior cerebral artery (PCA)
what is a stroke
syndrome characterised by rapidly developing clinical symptoms and/or signs of focal loss of cerebral function lasting for more than 24 hours/death and due to a vascular origin
What is a TIA
Transient ischemic attack
symptoms and signs last less than 24hrs
Acts as a warning for stroke
Sign that a clot may be forming
how many stroke deaths a year vs survivors
5.45 million strok deaths/year and 9 million stroke survivors world wide
What are the classifications of stroke
Ischaemic or haemorrhagic
What are the classifications of ischaemic stroke
Cardio-embolic
atherothrombo-embolic
small vessel disease
venous thrombosis
what is an ischaemic stroke
A stroke where blood supply to an area is prevented due to a clot or other blockage
What are characteristics of a cardio-embolic stroke
AF
Mural thrombus
paradoxical embolism through patent foramen ovale
Inefective endocarditis
What is the cause of atherothrombotic-embolic strokes
Forms in arteries
Carotid, vertebral, cerebral artery occlusion and carotid dissection
How does small vessel disease lead to stroke
easier to clot in small vessels
hypertensive arterial disease, diabetic vasculopathy and vasculitis
What is associated with venous thrombosis
Lying in bed for long time, need to check pt has not been clotting
What are types of haemorrhagic strokes
sub-arachnoid
parenchymal
What is sub-arachnoid stroke associated with?
Arterio venous malformation
Aneurysm
What is parenchymal stroke associated with?
Hypertensive arterial disease
amyloid angiopathy
What occurs to form an atherosclerotic artery
Fatty streaks form on the intimal layer of the wall
massive extracellular lipids
fibrous plaques with deposits of platelets and fibrin
This stiffens leading to kinking of artery, occlusion or narrowing, decreased perfusion pressure
In combination with HTN a major risk of injury due to stretch of the walls and burst blood vessels
What is a thromboembolism
A thrombus is build up such as a clot that forms in vessels
Part breaks off and travels to the brain
What is a berry aneurysm
Referred as “tiny bomb inside head”
if part weak when extra pressure can break and bleed in brain
‘berries’ form off of vessels such as internal carotid complex, anterior communicating, trifurcations
What is an avm
Means anteriovenous malformation
Artery continous across instead of separating into capilleries
Can lead to hypoxia causing brain cell death
What are moderate effects of ischaemia?
Inadequate O2 and glucose
Leads to Inadequate energy supply
Failure of neuronal activity and regional brain dysfunction
What are severe effects of ischaemia
Inadequate energy supply feeds
Influx of H2O, Na+. Cl- with influx of Ca+
Anaerobic metabolism results
Leads to irreversible cellular injury and accumulating lactic acid
H+, compromise neuronal integrity