Stress Flashcards
Definition of stress
discrepancy between perceived demands and perceived ability to cope
Endocrine
hormonal
Release of adrenaline and noradrenaline causes…
1) Glucose metabolism (energy increases in muscles)
2) increasing cardiac activity
3) increasing blood pressure
- > body prepares for fight-or-flight response
Release of steroid stress hormones causes…
1) Stored fats and proteins are converted into energy
2) suppression of the immune system
3) increased calcium release in the brain causes higher brain alertness
Steroid stress hormones include…
1) Glucocorticoids
Others are cortisol, cortisone, hydrocortisone, corticosterone
Hypothalamic-Pituitary-Adrenal axis (HPA axis)
mediates the endocrine and central nervous system stress response
adrenal glands
located above the kidneys
release steroids from their cortex (outside layer)
release (nor)adrenaline from their medulla (inside layer)
pituitary gland
located in brain
releases adrenocorticotrophic hormone (ACTH)
Adrenocorticotrophic hormone (ACTH)
released from the pituitary gland, activates the adrenal glands
hypothalamus
located in brain
releases adrenocorticotrophic hormone-releasing factor (ACTH-RF) or Corticotrophin-releasing hormone (CRH)
Adrenocorticotrophic hormone-releasing factor (ACTH-RF) or Corticotrophin-releasing hormone (CRH)
released from the hypothalamus, activates the pituitary gland
Corticotrophin-releasing hormone (CRH)
=Adrenocorticotrophic hormone-releasing factor (ACTH-RF)
Describe sensitivity of HPA system
highly sensitive to change, only mild unexpected stimuli trigger the release of CRH and the secretion of corticosterone,
but if the stimulus is harmless, activation quickly dies away without negative impacts,
if the stimulus is persistently perceived as requiring high vigilance, then higher brain centres override any negative feedback from corticosterone and the endocrine response continues
Autonomic nervous system (ANS)
additional stress response triggered by the hypothalamus, activates the adrenal medulla and thus release of (nor)adrenaline
Health risks of prolonged stress
Prolonged elevation of glucocorticoid levels can lead to diabetes, cancer, ulcers, increased blood cholesterol and even a shrinkage of the hippocampus