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Microbiology Exam 1 > Streptoccoci GAS > Flashcards

Streptoccoci GAS Flashcards

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Biology 101 flashcards
1
Q

Group A ______

A

streptoccoci pyrogenes

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2
Q

what does strep pyrogenes (SP) look like?

A

MRSA, white colonies with clear zones of Beta hemolysis. gram +

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3
Q

strep pyrogenes has a ______ antigen

A

carb

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4
Q

where does colonize? causes?

A

oropharynx, pharyngitis (not strep anigous)

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5
Q

catalase postive or negative?

A

negative

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6
Q

how does SP spread?

A

respiratory droplets and breaks in the skin

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7
Q

what time of year does SP occur most often?

A

colder months - pharyngitis rheum fever and glomerular nephritis —- warmer: skin dz

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8
Q

when you have a skin infection…

A

you assume is staph primarily bc both do skin. then do dx test.

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9
Q

S+S of strep throat? hard to differentiate from _____? how do you dx?

A

normal flu like symptoms and erythmatosis with exudate, palatal petichae. dx with serology or c+s. hard to differentiate from viral dz and mycoplasma

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10
Q

scarlet fever

A

complication of strep throat and pyro exotoxin.

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11
Q

S+S of scarlet fever

A

red face rash upper extremities and upper chest; strawberry tongue, yellowish stuff on tongue sheds off, peritonsillar or retropharyngeal abscess, OM, sinusitis

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12
Q

pyroderma impetigo

A

purulent infection of the skin, face UE LE, associated with strains that do not cz pharyngitis, skin breaks

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13
Q

when does SP start to use enzymes?

A

once it hits the facious layer or plain

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14
Q

eripselas

A

acute local painful skin infection. systematic and lymph. child fever and lymphocytosis

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15
Q

cellulitis

A

skin and deep, can only treat if know precise organism

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16
Q

necrotizing faceitis

A

strep more than staph. deep sq and fascia. skin break. 50% die. need to debride and abx

17
Q

progression from cellulitis

A

bullae, gangrene, sepsis, mods, death

18
Q

bacteremia - dx? babies?

A

in babies its gbs. but in gas you dx with a positive blood culture of beta hemolytic strep

19
Q

strep toxic shock syndrome

A

highly associated with bacteremia and ned facitis - soft tissue infection with nonspecific ss of systemic infection. progresses to mods.

associated with M types

20
Q

what toxin produces STSS?

A

SpeA or streptotoxigenic pyrotoxin A

21
Q

rheumatic fever - SS? dx?

A

complication of SP pharyngitis. post strep - no more bacteria. have paricardtitis, sq and in vessels. sq nodules on heart and tissues. damage to valves. joint involvement, specific m type

dx: no specific test to dx so you rely on recent strep infection/hx. also GAS increases ASP or anti streptomycin O antibody

22
Q

ASO

A

group A antigen increases anti streptomycin O antibody

23
Q

acute glomerular nephritis - SS? dx?

A

last protein s/p inflammation. acute. nephrogenic strep strains, edema htn hematura and proteinura.

ASO titer

24
Q

haluronic acid

A

capsule virulance. prevent phago via assembly of human ECM and prevent c3b from binding.

25
Q

LTA

A

capsule virulence. facilitates binding of host cells by complexing fibronectin - lipotechoic acid

26
Q

adhesions in SP

A

M protein

Fibronectin binds protein F

Cpa - collagen binding protein

27
Q

M protein - how do they mask?

A

type of adhesion. anchored to cyto membrane. N term is antigenic. many serotypes.

associated with rheumatic heart dz.

immunity to one sero type is good but keep in mind there are 100 serotypes and you don’t have immunity to the other 99

mask:

  1. binding to fibrinogen which coasts bacteria with host protein (so looks like self/host)
  2. antiphagocitic - decrease opsin effect and binds to Fc of IgG
28
Q

streptolysin O and dx?

A

SLO. SP virulence. enzyme. 02 labile. hemolysin of RBCS, leuk, plts. form pores. dx ab to “O” (and not “S”) + dx of previous infection

29
Q

Streptolysin S and dx?

A

SLS. virulence. enzyme. O2 stable. non immunogenic. lysis of RBC leuk. plts. via beta hemolysis- releases lysosome after engulfments. likes to be inside host. serum required for protection

dx - c+s beta hemolysis

30
Q

streptokinase

A

dissolved fibrin clots

31
Q

streptococcol inhibiter of complement

A

Sic - disables MAC complex

32
Q

C5a peptidase

A

inhibits chemotaxis of inflame mediators

33
Q

haluronidase

A

spread

34
Q

Streptococcal pyrogenic exotoxins

A

SpeS. mainly GAS. rash in scarlet fever. super antigens A and C. cz TSS.

35
Q

SpeA and SpeB protease - fxn?

A

A- rhematic fever

SpeB protease - destroys ECM - spread

Microbiology Exam 1 (6 decks)

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