strep skin

Question 1

Erysipelas

Answer 1

Caused by hemolytic Strep strains
Disease characteristics
* Resulting from complications of skin wounds
* Occurring in the variable demographic of young and old.
* Chills fever and systemic infection
* Bright red inflammation on face
* Interacts with the lymphatic system

Question 2

Pyoderma

Answer 2

Disease characteristics
* Common in young dirty children (summer)
* Colonization by direct contact and infiltration through a skin break.
* Could result in AGN if left untreated.

Question 3

Virulent Strep A strains

Answer 3

• Larger inflammatory repose in host tissues
• Flesh-eating (necrotizing fasciitis
• Necrosis of skin and subcutaneous tissue
• These infections can be very rapid and progressive
• Exotoxin A acts as a superantigen causing intense inflammatory response.

Question 4

what antibiotic should be used to treat skin diseases related to strep

Answer 4

Penicillin and erythromycin

Question 5

what are some general charateristics associated with strep

Answer 5

Mostly facultative anaerobes
Strep
Optimally grown on blood agar (beta-hemolytic pattern)
Transient

Question 6

what are some general virulence factors associated with strep

Answer 6

• Capsule
• Hyaluronic acid found withing the host tissue is also found within the capsule mimic the acids found within the host tissue which allow for invasion of host immune response.
• Antigenic nature
• M and F protein M proteins are the hair bits on the surface of the capsule, F protein binds to Fibronectin
• Lipoteichoic acid  associated with fibre and plays a role in attachment
• Pyrogenic exotoxins
• Fever inducing
• Streptolysins
• Destruction of host defense cells
• Streptokinase’s
• Breaking down blood clots
• DNase
• Able to degrade Free DNA aiding in spread.