- Strand Viruses Flashcards
Describe the content of a - strand RNA virus
- Replicase protein: Makes + strand
Where does - strand RNA viruses replicate?
In the cytoplasm except for orthomyxoviruses
Name the viruses belonging to the Paramyxoviridae family.
Measles, Mumps, Parainfluenza, Human Respiratory syncytial virus
Discuss Parainfluenza virus
- Aerosol and Fomites transmission
2. Causes croup (barking cough)
Explain RSV pathogenesis
- Enters via eye or nose
- Spreads along respiratory tract via cell to cell transfer
- Causes fever, rhinitis, pharyngitis
What is the treatment for RSV?
Ribovirin; A guanosine analogue that inhibits guanine synthesis, guanylation and mRNA capping.
Discuss Mumps Virus
- Transmission via Aerosol and Fomite
- Infects epithelium
- Contagion period PRECEDS symptoms
- Only one serotype, life long immunity.
- Causes Parotitis
Discuss Measles
- Patient contagious 7 days prior to through 4 days after onset of symptoms.
- Predromal stages present with flu-like symptoms
- Koplik’s spots
- Maculopapular rash
Discuss Rubella
Single stranded + RNA; Enveloped
Explain the pathogenesis of Rubella
- Enters and infects nasopharynx/lungs
- Spreads to lymph nodes
- Virus can infect the placenta and spread to fetus.
Describe congenital rubella symptoms
Hearing loss, Ductus Arteriosus, Thrombocytopenic purpura
Describe the Orthomyxoviridae viruses
- Enveloped - strand RNA
2. Contains neuraminidase, hemagglutinin and channel protein
Discuss Influenza virus mutation
Influenza A > B > C; HA and NA proteins are major antigenic determinants of the virus.
Define antigenic shift
Mutation of genomes due to errors during replication.
Discuss Swine flu
Can infect cells with both alpha 2,3 and 2,6 linkages in sialic acids
