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ACLAM Exam 2023 > Strains and Stocks > Flashcards

Strains and Stocks Flashcards

1
Q

A

A

Albino
Age-related hearing loss
Research use: carcinogen-induced lung tumors, developmental biology (cleft palate), muscular dystrophy (dysf gene)
Spontaneous disease: high incidence of lung adenoma, predisposed to congenital malformations, amyloidosis
Hepatic tumors with H. hepaticus infection

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2
Q

AKR

A

Albino
Ecotropic retrovirus in all tissues, viremic from birth, high rate of T-cell lymphoma/leukemia
Paralysis with LDV
Males get urinary obstruction

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3
Q

129

A

16 substrains - white belly agouti (Aw) or albino.
Used for ES cell lines and to generated Tm strains
High incidence of testicular teratoma, arteritis, acidophilic macrophage pneumonia

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4
Q

BALB/c

A

Albino
Age-related hearing loss
Research use: monoclonal antibody production, plasmacytoma with injection of mineral oil
Spontaneous disease: cardiac calcinosis, hypocallosity, Reye’s-like syndrome, polycystic kidney disease

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5
Q

C3H

A

Agouti
Retinal degeneration
Spontaneous disease: cardiac calcinosis, liver tumors (hepatoma), mammary adenocarcinoma, alopecia areata
TLR4 - highly susceptible to gram negative infection

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6
Q

C57BL/6

A

Black
Hearing loss
Spontaneous disease: hydrocephaply, malocclusion, lymphoma, micropthalmia, amyloidosis, barbering/UD, postpartum ileus
Susceptible to diet-induced atherosclerosis/obesity/type 2 DM

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7
Q

DBA/2

A

Dilute brown nonagouti
Hearing loss
Spontaneous disease: cardiac + soft tissue mineralization, glaucoma, audiogenic seizures (young age)
Complement C5 deficient
Resistant to diet-induced atherosclerosis

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8
Q

FVB

A

Albino
Retinal degeneration
Research use: transgenic development due to large pronucleus, airway responsiveness/asthma, chemical-induced SCC
Spontaneous disease: epilepsy, auditory seizures

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9
Q

SJL

A

Albino
Retinal degeneration
Research use: EAE, muscular dystrophy (dysf gene)
Spontaneous disease: reticulum cell sarcoma, amyloidosis

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10
Q

SWR

A

Albino
Retinal degeneration
Research use: EAE
Spontaneous disease: lung tumors, mammary gland tumors, diabetes insipidus

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11
Q

Inbred mouse strains with retinal degeneration

A

SWR
SJL
FVB
C3H
CBA

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12
Q

Inbred mouse strains with age-related hearing loss

A

BALB/c
A
C57
129
NOD
DBA

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13
Q

Inbred mouse strains with dystrophic mineralization

A

BALB/c (epicardial)
C3H (cardiac)
DBA (cardiac + soft tissue)

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14
Q

Inbred mouse strains with audiogenic seizures

A

DBA/2 (at young ages, then hearing loss)
FVB
SJL

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15
Q

Inbred strains susceptible to primary amyloidosis

A

A
SJL
C57BL/6 (older)

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16
Q

Inbred strains resistant to primary amyloidosis

A

BALB/c
C3H

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17
Q

Inbred strains with dysf mutation

A

A
SJL

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18
Q

Inbred strains with high rates of male aggression

A

BALB/c
SJL
FVB

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19
Q

Nude mouse

A

Foxn1 gene
T cell deficient
Hairless

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20
Q

SCID mouse

A

Prkdc^scid mutation
T and B cell deficient
Susceptible to ionizing radiation

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21
Q

Rag1/Rag2 mouse

A

RAG1 or RAG2 gene
T and B cell deficient
“non-leaky”

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22
Q

NOD

A

Albino
Hearing loss
Type 1 DM
Defects in antigen presentation, T lymphocyte repertoire, NK cell function, macrophage cytokine production, and C5 complement

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23
Q

NSG

A

T and B cell deficient
NK cell deficient
Complement deficient
Impaired macrophage and dendritic cell function

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24
Q

XID

A

Burton’s tyrosine kinase gene defect
Decreased B cells, low IgM
Model of x-linked agammaglobulinemia

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25
Moth-eaten
T and NK cell deficient Autoimmune syndrome, hypergammaglobulinemia Folliculitis leads to moth eaten coat
26
Beige
Lyst(bg) mutation Model for Chediak-Higashi syndrome, lysosomal storage disease Decreased NK activity, decreased neutrophil function
27
RFM mice
Atrial thrombosis
28
CBA
Research use: granulomatous experimental autoimmune thyroiditis, Spontaneous disease: Exocrine pancreatic insufficiency, renal tubulointerstitial lesions
29
NZB
Autoimmune disease - hemolytic anemia, glomerulonephritis
30
Inbred strains with high rate of mammary tumors
C3H A DBA/2
31
Inbred strains with low rate of mammary tumors
BALB/c C57BL AKR
32
ACI rat
Black agouti with white belly and feet Congenital genitourinary abnormalities (renal agenesis/hypoplasia, hydronephrosis) Testicular and prostatic tumors Susceptible to estrogen-induced mammary tumors
33
BB/Wor rat
Albino Type 1 diabetes mellitus
34
BN (Brown Norway)
Brown Airway hyperresponsiveness/asthma, eosinophilic granulomatous pulmonary inflammation Bladder tumors, hydronephrosis, transplantable myeloid leukemia
35
BUF (Buffalo)
Albino Autoimmune thyroiditis
36
COP (Copenhagen)
Hooded Prostatic adenocarcinoma
37
F344
Albino National Toxicology Program's Carcinogen Bioassay Program and National Institute on Aging rat Interstitial/leydig cell tumors, large granular lymphocytic leukemia, CPN, corneal mineralization, nephrocalcinosis
38
LEW (Lewis)
Albino Autoimmune disease model, EAE, multiple sclerosis
39
LOU/C
Albino Myeloma, Plasmacytoma, IgG autoantibody
40
SHR
Albino Spontaneous hypertensive rat Hypertension, polyarteritis nodosa
41
WF (Wistar-Furth)
Albino Mononuclear cell leukemia Fuzzy mutation - dermatology research Inducible carcinoma of the mammary gland
42
Zucker
Hooded Obesity, type 2 DM Increased incidence of urinary tract infections and urolithiasis
43
Brattleboro
Hooded (?) Diabetes insipidus (autosomal recessive) Vasopressin deficiency
44
Gunn
Albino (?) Jaundice, unconjugated hyperbilirubinemia (autosomal recessive defect of bilirubin glucuronidation, UGT); Crigler-Najjar syndrome Hydronephrosis (single dominant gene)
45
Obese SHR
Type 4 hyperlipoproteinemia (autosomal recessive)
46
Nude rat
Hooded Foxn1 - rnu Autosomal recessive
47
Sprague Dawley
Outbred stock; albino Spontaneous disease: polyarteritis nodosa, pituitary adenoma (chromophobe adenoma most common), mammary fibroadenoma, CPN, chronic myocardial disease Larger than Wistar
48
Wistar
Outbred stock; Albino Seizures Smaller than Sprague-Dawley
49
Long Evans
Outbred stock; hooded
50
Royal college of surgeons rat (RCS)
Tan hooded Retinal degeneration
51
Long-evans Cinnamon rat
"Cinnamon-like", kinda looks tan hooded but with more tan Copper accumulation in liver; Wilson's disease
52
Dahl rat
Albino Hypertension and renal failure on high-salt diet; hyperlipidemia, insulin resistance
53
FHR (Fawn-Hooded Rat)
Fawn hooded Hypertension
54
Substrain designation occurs if two colonies of inbred mice are...
Separated before F40 Separate for 100 generations If genetic differences arise
55
Wistar-Kyoto
Normotensive control for SHR High rates of cardiac septal defects, resulting in right ventricular hypertrophy
56
KHC Rabbit
Kurosawa and Kusanagi Hypercholesterolemic rabbit Autosomal recessive - LDL receptor gene has a 12bp deletion Elevated serum cholesterol, triglyceride, phospholipid; decreased HDL
57
WHHL rabbit
Watanabe heritable hyperlipidemia Marked deficiency of LDL receptors Increased incidence of athersclerosis
58
St Thomas Hospital strain rabbits
Normal functioning LDL receptor Hypercholesterolemic
59
IAF guinea pig
Hairless Derm tox
60
Abyssinian guinea pig
Long hair in whorls
61
Peruvian guinea pig
Long straight hair
62
Yucatan minipig
Grey-ish/black color Mini and micro sizes Lineage with VSD Lineage that is white/hairless for derm studies
63
Hanford minipig
Largest minipig White Device implant studies, dermal studies
64
Sinclair minipig
White (lots of hair) Malignant, spontaneously regressing, melanoma Slow growers
65
Gottingen
Smallest minipig White color Used in pharma/tox Prone to type III hypersensitivity - thrombocytopenic purpura
66
Ossabaw swine
Black or black/tan spotted Diabetes and metabolic syndrome
67
Rapacz familial hypercholesterolemia pigs
Atherosclerosis
68
Norwegian yorkshire swine
Inherited form of autoimmune glomerulonephritis
69
Gal-KO pig
Knockout of the gene that encodes for alpha1,3Gal Background breed - MGH, SLAdd line (most inbred)
70
MGH swine
Massachusetts general hospital Homozygous for defined SLA/MHC SLAaa, SLAcc, SLAdd SLAdd further inbred
71
Swine breeds susceptible to porcine stress syndrome
Landrace Yorkshire Duroc Pietrain Poland China
72
Landrace pig
Big and white Ears point down, long snout
73
Yorkshire pig
Big and white Ears point up, shorter snout
74
Duroc pig
Big and brown
75
Pietrain pig
White with black spots
76
1.50 syrian hamster
Cardiomyopathy Defect in the sarcoglycan gene
77
APA hamster
"Albino-panda-albino" hamster Diabetric nephropathy after STZ administration Develop atrial thrombosis more commonly (maybe due to cardiac hypertrophy)
78
Gray collies
Cyclic hematopoiesis Periodic fluctuations in neutrophil population
79
Golden retrievers
Duchenne muscular dystrophy X-linked recessive
80
Doberman pinscher
Narcolepsy
81
Bedlington terrier
Copper storage (Wilson's) disease
82
Abyssinian cat
Retinal degeneration rdAc
83
Corriedale sheep
Dubin-Johnson syndrome (congenital hyperbilirubinemia) Conjugated Hepatic anion excretory defect Big white and very puffy
84
Southdown sheep
Gilbert's syndrome (congenital hyperbilirubinemia) Unconjugated Hepatic anion uptake defect Little white and only a little puffy
85
Rambouillet sheep
Gamma-glutamyl carboxylase deficiency Yellow-white with big horns
86
Holstein cattle
Inherited cardiomyopathy Leukocyte adhesion deficiency Chediak-Higashi
87
Fainting goats
Myotonia congenita
88
Quiver quail
Neurofilament deficient mutant quail Wide-spread tremors
89
Complement 4 deficient guinea pig
Partially dominant mode of inheritence (Heterozyogtes are intermediate) Susceptible to syphylis
90
Wz guinea pig
Waltzing Spontaneous Autosomal dominant, full penetrance

ACLAM Exam 2023 (5 decks)

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