Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

ACLAM Exam 2023 > Strains and Stocks > Flashcards

Strains and Stocks Flashcards

1
Q

A

A

Albino
Age-related hearing loss
Research use: carcinogen-induced lung tumors, developmental biology (cleft palate), muscular dystrophy (dysf gene)
Spontaneous disease: high incidence of lung adenoma, predisposed to congenital malformations, amyloidosis
Hepatic tumors with H. hepaticus infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

AKR

A

Albino
Ecotropic retrovirus in all tissues, viremic from birth, high rate of T-cell lymphoma/leukemia
Paralysis with LDV
Males get urinary obstruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

129

A

16 substrains - white belly agouti (Aw) or albino.
Used for ES cell lines and to generated Tm strains
High incidence of testicular teratoma, arteritis, acidophilic macrophage pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

BALB/c

A

Albino
Age-related hearing loss
Research use: monoclonal antibody production, plasmacytoma with injection of mineral oil
Spontaneous disease: cardiac calcinosis, hypocallosity, Reye’s-like syndrome, polycystic kidney disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

C3H

A

Agouti
Retinal degeneration
Spontaneous disease: cardiac calcinosis, liver tumors (hepatoma), mammary adenocarcinoma, alopecia areata
TLR4 - highly susceptible to gram negative infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

C57BL/6

A

Black
Hearing loss
Spontaneous disease: hydrocephaply, malocclusion, lymphoma, micropthalmia, amyloidosis, barbering/UD, postpartum ileus
Susceptible to diet-induced atherosclerosis/obesity/type 2 DM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

DBA/2

A

Dilute brown nonagouti
Hearing loss
Spontaneous disease: cardiac + soft tissue mineralization, glaucoma, audiogenic seizures (young age)
Complement C5 deficient
Resistant to diet-induced atherosclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

FVB

A

Albino
Retinal degeneration
Research use: transgenic development due to large pronucleus, airway responsiveness/asthma, chemical-induced SCC
Spontaneous disease: epilepsy, auditory seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

SJL

A

Albino
Retinal degeneration
Research use: EAE, muscular dystrophy (dysf gene)
Spontaneous disease: reticulum cell sarcoma, amyloidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

SWR

A

Albino
Retinal degeneration
Research use: EAE
Spontaneous disease: lung tumors, mammary gland tumors, diabetes insipidus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Inbred mouse strains with retinal degeneration

A

SWR
SJL
FVB
C3H
CBA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Inbred mouse strains with age-related hearing loss

A

BALB/c
A
C57
129
NOD
DBA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Inbred mouse strains with dystrophic mineralization

A

BALB/c (epicardial)
C3H (cardiac)
DBA (cardiac + soft tissue)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Inbred mouse strains with audiogenic seizures

A

DBA/2 (at young ages, then hearing loss)
FVB
SJL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Inbred strains susceptible to primary amyloidosis

A

A
SJL
C57BL/6 (older)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Inbred strains resistant to primary amyloidosis

A

BALB/c
C3H

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Inbred strains with dysf mutation

A

A
SJL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Inbred strains with high rates of male aggression

A

BALB/c
SJL
FVB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Nude mouse

A

Foxn1 gene
T cell deficient
Hairless

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

SCID mouse

A

Prkdc^scid mutation
T and B cell deficient
Susceptible to ionizing radiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Rag1/Rag2 mouse

A

RAG1 or RAG2 gene
T and B cell deficient
“non-leaky”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

NOD

A

Albino
Hearing loss
Type 1 DM
Defects in antigen presentation, T lymphocyte repertoire, NK cell function, macrophage cytokine production, and C5 complement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

NSG

A

T and B cell deficient
NK cell deficient
Complement deficient
Impaired macrophage and dendritic cell function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

XID

A

Burton’s tyrosine kinase gene defect
Decreased B cells, low IgM
Model of x-linked agammaglobulinemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Moth-eaten

A

T and NK cell deficient
Autoimmune syndrome, hypergammaglobulinemia
Folliculitis leads to moth eaten coat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Beige

A

Lyst(bg) mutation
Model for Chediak-Higashi syndrome, lysosomal storage disease
Decreased NK activity, decreased neutrophil function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

RFM mice

A

Atrial thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

CBA

A

Research use: granulomatous experimental autoimmune thyroiditis,
Spontaneous disease: Exocrine pancreatic insufficiency, renal tubulointerstitial lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

NZB

A

Autoimmune disease - hemolytic anemia, glomerulonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Inbred strains with high rate of mammary tumors

A

C3H
A
DBA/2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Inbred strains with low rate of mammary tumors

A

BALB/c
C57BL
AKR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

ACI rat

A

Black agouti with white belly and feet
Congenital genitourinary abnormalities (renal agenesis/hypoplasia, hydronephrosis)
Testicular and prostatic tumors
Susceptible to estrogen-induced mammary tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

BB/Wor rat

A

Albino
Type 1 diabetes mellitus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

BN (Brown Norway)

A

Brown
Airway hyperresponsiveness/asthma, eosinophilic granulomatous pulmonary inflammation
Bladder tumors, hydronephrosis, transplantable myeloid leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

BUF (Buffalo)

A

Albino
Autoimmune thyroiditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

COP (Copenhagen)

A

Hooded
Prostatic adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

F344

A

Albino
National Toxicology Program’s Carcinogen Bioassay Program and National Institute on Aging rat
Interstitial/leydig cell tumors, large granular lymphocytic leukemia, CPN, corneal mineralization, nephrocalcinosis

38
Q

LEW (Lewis)

A

Albino
Autoimmune disease model, EAE, multiple sclerosis

39
Q

LOU/C

A

Albino
Myeloma, Plasmacytoma, IgG autoantibody

40
Q

SHR

A

Albino
Spontaneous hypertensive rat
Hypertension, polyarteritis nodosa

41
Q

WF (Wistar-Furth)

A

Albino
Mononuclear cell leukemia
Fuzzy mutation - dermatology research
Inducible carcinoma of the mammary gland

42
Q

Zucker

A

Hooded
Obesity, type 2 DM
Increased incidence of urinary tract infections and urolithiasis

43
Q

Brattleboro

A

Hooded (?)
Diabetes insipidus (autosomal recessive)
Vasopressin deficiency

44
Q

Gunn

A

Albino (?)
Jaundice, unconjugated hyperbilirubinemia (autosomal recessive defect of bilirubin glucuronidation, UGT); Crigler-Najjar syndrome
Hydronephrosis (single dominant gene)

45
Q

Obese SHR

A

Type 4 hyperlipoproteinemia (autosomal recessive)

46
Q

Nude rat

A

Hooded
Foxn1 - rnu
Autosomal recessive

47
Q

Sprague Dawley

A

Outbred stock; albino
Spontaneous disease: polyarteritis nodosa, pituitary adenoma (chromophobe adenoma most common), mammary fibroadenoma, CPN, chronic myocardial disease
Larger than Wistar

48
Q

Wistar

A

Outbred stock; Albino
Seizures
Smaller than Sprague-Dawley

49
Q

Long Evans

A

Outbred stock; hooded

50
Q

Royal college of surgeons rat (RCS)

A

Tan hooded
Retinal degeneration

51
Q

Long-evans Cinnamon rat

A

“Cinnamon-like”, kinda looks tan hooded but with more tan
Copper accumulation in liver; Wilson’s disease

52
Q

Dahl rat

A

Albino
Hypertension and renal failure on high-salt diet; hyperlipidemia, insulin resistance

53
Q

FHR (Fawn-Hooded Rat)

A

Fawn hooded
Hypertension

54
Q

Substrain designation occurs if two colonies of inbred mice are…

A

Separated before F40
Separate for 100 generations
If genetic differences arise

55
Q

Wistar-Kyoto

A

Normotensive control for SHR
High rates of cardiac septal defects, resulting in right ventricular hypertrophy

56
Q

KHC Rabbit

A

Kurosawa and Kusanagi Hypercholesterolemic rabbit
Autosomal recessive - LDL receptor gene has a 12bp deletion
Elevated serum cholesterol, triglyceride, phospholipid; decreased HDL

57
Q

WHHL rabbit

A

Watanabe heritable hyperlipidemia
Marked deficiency of LDL receptors
Increased incidence of athersclerosis

58
Q

St Thomas Hospital strain rabbits

A

Normal functioning LDL receptor
Hypercholesterolemic

59
Q

IAF guinea pig

A

Hairless
Derm tox

60
Q

Abyssinian guinea pig

A

Long hair in whorls

61
Q

Peruvian guinea pig

A

Long straight hair

62
Q

Yucatan minipig

A

Grey-ish/black color
Mini and micro sizes
Lineage with VSD
Lineage that is white/hairless for derm studies

63
Q

Hanford minipig

A

Largest minipig
White
Device implant studies, dermal studies

64
Q

Sinclair minipig

A

White (lots of hair)
Malignant, spontaneously regressing, melanoma
Slow growers

65
Q

Gottingen

A

Smallest minipig
White color
Used in pharma/tox
Prone to type III hypersensitivity - thrombocytopenic purpura

66
Q

Ossabaw swine

A

Black or black/tan spotted
Diabetes and metabolic syndrome

67
Q

Rapacz familial hypercholesterolemia pigs

A

Atherosclerosis

68
Q

Norwegian yorkshire swine

A

Inherited form of autoimmune glomerulonephritis

69
Q

Gal-KO pig

A

Knockout of the gene that encodes for alpha1,3Gal
Background breed - MGH, SLAdd line (most inbred)

70
Q

MGH swine

A

Massachusetts general hospital
Homozygous for defined SLA/MHC
SLAaa, SLAcc, SLAdd
SLAdd further inbred

71
Q

Swine breeds susceptible to porcine stress syndrome

A

Landrace
Yorkshire
Duroc
Pietrain
Poland China

72
Q

Landrace pig

A

Big and white
Ears point down, long snout

73
Q

Yorkshire pig

A

Big and white
Ears point up, shorter snout

74
Q

Duroc pig

A

Big and brown

75
Q

Pietrain pig

A

White with black spots

76
Q

1.50 syrian hamster

A

Cardiomyopathy
Defect in the sarcoglycan gene

77
Q

APA hamster

A

“Albino-panda-albino” hamster
Diabetric nephropathy after STZ administration
Develop atrial thrombosis more commonly (maybe due to cardiac hypertrophy)

78
Q

Gray collies

A

Cyclic hematopoiesis
Periodic fluctuations in neutrophil population

79
Q

Golden retrievers

A

Duchenne muscular dystrophy
X-linked recessive

80
Q

Doberman pinscher

A

Narcolepsy

81
Q

Bedlington terrier

A

Copper storage (Wilson’s) disease

82
Q

Abyssinian cat

A

Retinal degeneration
rdAc

83
Q

Corriedale sheep

A

Dubin-Johnson syndrome (congenital hyperbilirubinemia)
Conjugated
Hepatic anion excretory defect
Big white and very puffy

84
Q

Southdown sheep

A

Gilbert’s syndrome (congenital hyperbilirubinemia)
Unconjugated
Hepatic anion uptake defect
Little white and only a little puffy

85
Q

Rambouillet sheep

A

Gamma-glutamyl carboxylase deficiency
Yellow-white with big horns

86
Q

Holstein cattle

A

Inherited cardiomyopathy
Leukocyte adhesion deficiency
Chediak-Higashi

87
Q

Fainting goats

A

Myotonia congenita

88
Q

Quiver quail

A

Neurofilament deficient mutant quail
Wide-spread tremors

89
Q

Complement 4 deficient guinea pig

A

Partially dominant mode of inheritence (Heterozyogtes are intermediate)
Susceptible to syphylis

90
Q

Wz guinea pig

A

Waltzing
Spontaneous
Autosomal dominant, full penetrance

ACLAM Exam 2023 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions