Stomach Disorders Flashcards
Caused by dietary indiscretion
• person eats food that is irritating too highly seasoned it contaminated with disease causing microorganisms
• overuse of ASA and other NSAIDS
• bile reflux
• radiation therapy
• strong acid or alkali
• major traumatic injuries, burns, severe infection, hepatic, renal, resp failure
Acute gastritis
Prolonged inflammation of the stomach maybe caused by benign or malignant ulcers of the stomach • bacteria H. Pylori • auto immune disease, anemia, • caffeine • NSAIDS, bisphonates, Alendronate • alcohol • smoking • chronic reflux of pancreatic secretions and bile
Chronic gastritis
Rapid onset • abdm discomfort • headache • lassitude • nausea/vomiting/hiccups • fatigue
Last few hours to few days
Clinical manifestations of acute gastritis
- anorexia
- heart burn after eating
- belching
- sour taste in the mouth
- nausea/Vomiting
- mild epigastric discomfort/ intolerance to spicy or fatty foods
- slight pain relieved eating
- Vitamin B12 malabsorption
Clinical manifestations of chronic gastritis
Absence of HCL
Achlorhydia
Achlorhydia
Hypochlorhydia
Hyperchlorhydria
Gastritis
Refrain from alcohol and food until symptoms subside
Acute gastritis
Modifying the patients diet promoting rest
reducing stress
avoidance of alcohol and NSAIDS
Chronic gastritis
Reduce is the secretion of pancreatic bicarbonate which inhibits the neutralization of gastric acid in the duodenum
Nicotine
Antibiotic
• assists and eradicating H pylori bacteria and gastric mucosal
• May cause diarrhea
•should not be used in patients allergic to penicillin
Amoxicillin
Antidiarrheal
• suppresses H. Pylori bacteria and the gastric mucosa and assist with healing of mucosal ulcers
• given concurrently with antibiotics to eradicate H. Pylori infection
• should be taken on an empty stomach
Bismuth subsalicylate
Histamine H2 receptor
• decreases amount of HCl produced by stomach by blocking action of histamine on histamine receptors On parietal cells in the stomach
• least expensive of H3 receptor antagonist
• May cause confusion agitation or,coma in the elderly or those with renal or hepatic insufficiency
•long-term use me cause diarrhea dizziness and gynecomastia
• drug interactions: amiodarone, amitriptyline, benzodiazepine, metoprolol, nifedipine, phenytoin, warfarin
Cimetidine
- Best choice for critically ill patients because it is known to have the least risk of drug interactions
- does not alter liver metabolism prolonged halfway in patients with renal insufficiency
- H2 antagonist
- used short term of GERD
Famotidine
Pepcid
H2 antagonist
• Prolonged half-life impairment with patients Renal and hepatic insufficiency
• causes fewer side effects than cimetidine
• May cause headaches dizziness constipation nausea vomiting and a abdominal discomfort
Ranitidine
Zantac
Proton pump inhibitors
• decreases gastric acid secretion by slowing the hydrogen- potassium adenosine triphosphate ( H, K, ATPase) pump on the surface of the parietal cells of the stomach
•Used mainly for treatment of duodenal ulcer disease and H. pylori infection
• A delayed release capsule that is to be swallowed a whole and taken before meals
Esomeprazole
Nexium