Stomach Flashcards
Cardia and antrum luined with?
G cells secrete? parietal cells? chief?
Gastropathy and acute gastritis
gastritis is what process? reffered to as acute when? gastropathy when? what is it casues? 4
sympotms- common? 3 severe? 6
Path-gastric pH? protects gastric mucosa? pH? result of? physical barrier? replacement of these cells every?
what is an alkaline tide?
Gastropathy/acute gastritis/chronic
path- disruption of what mechanisms? 4
N- effect what?
U/P- works how?
R- what? 2
DO- account for increased what?
chemicals?
Gastropathy/actue gastritis 3
Morph- lamina propria show? foveolar cell? charactersitic what? what lymphocye?
presence of what above basement membrane is abnormal?
in the lumen? acute erosive hemorrhagic gastritis?
clin- actue gastritis vs gastropathy? nsaid induced repsonds to? pain where? bile reflux in comparison?
Stress-related mucosal disease
occurs in what patients?
stress ulcer- in what individuals?
curling? location?
Cushing? location? high incidence of?
Path-realted to? why? upreg of what? 2 increased what is protective?
Stress-related mucosal disease
morph- acute ulcers shape? size? base color? why? number?
micro- transition? vs chronic peptic ulcers?
Stress-related mucosal disease
clin- most of what pop? phrophylatic? clin outcome determined by?
non stress related- 2? casued by?
Chronic gastritis
most common cause? other major cause?
symptoms compared to acute? whats uncommon?
H. pylori gastritis
shape? present in what type of ulcers? what part of stomach often affected?
epidem- race? living? primary carrier? transmision route?
Path- often presents as what type of gastritis? with what abnormality? increased risk of what ulcer if in antrum?
in body and fundus- associated with what?
H.pylori chronic gastritis
path- virulence due to? 4
what gene is often in gastric cancer risk?
cytokines? iron?
H.pylori morph
location? tropism for what type of tissue?
most often found whre? lamina propria large numbers of what cell?
loing standing extend to where? atrophy associated with?
H. Pylori
Clin- testing via? 3
biopsy analyzed by? 3
treatments?
Autoimmune Gastritis (chronic gastritis)
location in stomach?
characterized by? 5 anti to? reduced? hyperplasia of? dificiency?
Path- loss of? responsible for? abseence stims? vit defic? leads to? reduced seum leads to chief cell death? damage compared to H.pylori?
type of cells against pareital? specific against?
Autoimmune Gastritis
morph- type of damage? where? thinned? RBC?
loss of what cells? hyperlasia demonstarated with proteins such as? can go to what cancer?
Autoimmune gastritis
clin- gastric atrophy? anemia?
age? gender? associated with what diseases?
B12 can cause other than megaloblasts?
cured by replacement?
Complication of chronic gastritis
PUD- what is it? mostly associated to?3
most common? lesser acid secretion in? why cant affect other areas?
aicd secreted by what can also cause? 2 esophagus? via?
epidem- raising or falling? but?
PUD
path- results from imbalances between?
morph- most common whre? gastric where? grouped? size and depth? describe ulcer?
if heaped up? present in serosa? perforation seen via?
base of ulcer is? infiltrate? bleeding risk? malignant transformation?
PUD- clin
recurrent? morbidity? symptoms? shitty causes? pain worse when? timing?
recurrence?
complications table
Hypertrophic gastropathies characterized by?
Menetrier- associated with excessive? low?
symptoms?
pediatric vs adult? cancer in?
morph- enlargement of? where? spared? most characteristic?
tratment?
Zollinger-ELlison
caused by? secretes? found where? present with?
most remarkable feature anatomically? due to?
treatment? malignant?
sporadic? gene?
INflammatory and hyperplastic polyps
common? age? size to resect?
morph- shape? surface? what is irregular dilated and elongated?
Fundic Gland Polyps
occur in what pops? 2
increasing due to? how?
morph- occur where? shape? group? composed of? lined by?
Gastric adenoma
increaes with? age? dysplasia? occur on background of?
adenocarcinoma risk related to?
morph- grouped? location? type of cells? exhibit?
high grade dysplasia?
Gastric Adenocarcinoma
common in stomach? 2 types? differ how? early symptoms? this results in? late symptoms?
epidem- high incidence where? help in these areas? metastasis common?
more common in wich groups?
US rates?
Gastric adenocarninoma
cause in reduction due to? cancer where on the rise? due to?
Gastric Adenocarcinoma path
hereditary? familial gene? encodes for? also present in? so?
diffuse higher chance with which mutation?
seen in majority sporadic?
intestinal type/sporadic- mutations in what? so loss of? other suppressor genes? 3
cytokines?
Gastric adenocarcinoma
morph- mainly where?
intestinal- type of tumor? type of structures? penetrate where?
diffuse- cells? cohesive? glands? large what?
both have lots of what ?
Gastric adenocarc
clin- type in high risk areas? age? gender?
diffuse- precursor lesions? gender?
prognositc indicators?
5 year?
Lymphoma
most common location?
type of cell? called?
often what virus?
Lymphoma
path- arise at what sites? or?
in stomach most often due to? so treatment?
translocations 3
11-18 brings what? the other two?
net effect for all 3?
H.pylori does this through? differ in treatment?
become more aggressive via?
Lymphoma morph
location? infiltrate of? lesions? follicles?
B-cell markers? do not express?
immunoglobulins?
clin- symptoms
Carcinoid tumor
from components of? mainly found where? associated with? 4
can be caused by what therapy?
morph- mucosa? color? hardness? in bowells? cytoplasm?
markers?
Carcinoid tumor
clin- age? symptoms determiend by?
if confined to intestine?
so carcinoid sydrome associated to?
prognostic factor? forgut? midgut? hindgut?
Gastrointestinal Stromal Tumor
type of tissue? named via? most common of stomach?
arise from what cells?
epidem- odd presentation?
age? chldren realted to? triad?
more GISt in what individuals?
Gastrointestinal stromal tumor
path- gain of fucntion?
lesser gen emutation?
mutation of what 2 detectable in what size? chromosomes?
Gastrointestinal stromal tumor
clin- blood?
treatment? prognosis?
