STIs Flashcards

1
Q

What is the most common bacterial STI?

A

chlamydia

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2
Q

24 y/o man presents with discharge from penis and pain passing urine - diagnosis?

A

gonorrhoea

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3
Q

In which stage of syphilis does a chancre develop?

A

primary

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4
Q

Viral shedding is higher in which strain of herpes simplex virus?

A

HSV2

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5
Q

What type of organism is chlamydia trachomatis?

A

gram negative obligate intracellular bacterium

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6
Q

22 y/o female presents with post-coital bleeding, lower abdomen pain, dyspareunia and mucopurulent vaginal discharge.
Diagnosis and treatment?

A

chlamydia and doxycycline 100mg bd for 1 week

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7
Q

What are some of the complications of a chlamydia infection?

A
PID
Tubal damage
Chronic pelvic pain
Transmission to neonate 
Reactive arthritis 
Fitz-Hugh-Curtis syndrome
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8
Q

A baby is born with sticky looking eyes - what do you swab for?

A

chlamydia

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9
Q

What is the triad of reactive arthritis?

A

urethritis
arthritis
conjunctivitis

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10
Q

Which complication of a CT infection involves peri-hepatitis?

A

Fitz-Hugh-Curtis syndrome - liver capsule inflammation creating piano-string adhesions between the liver, abdomen & diaphragm.

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11
Q

You should test women >25 y/o with vaginal discharge for CT as this is the most likely diagnosis.
T/F?

A

FALSE

more likely to be candida or BV

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12
Q

What is LGV, in who is it seen and what are the symptoms?

A

Lymphogranuloma venereum Serovars L1-L3 of CT

Diagnosed tropical cases & MSM - rectal pain, discharge and bleeding - similar to IBD.

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13
Q

How would you diagnose chlamydia in patients (male & female)?

A

NAAT: females –> vulvovaginal swab

males –> first void urine

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14
Q

What is the 1st line treatment for chlamydia?

A

doxycycline 100mg bd for 1 week

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15
Q

what is the 2nd line treatment for chlamydia?

A

azithromycin 1g stat followed by 500mg daily for 2 days

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16
Q

What is an emerging STI associated with non-gonococcal urethritis and PID?

A

mycoplasma genitalium

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17
Q

What are serovars A-C of chlamydia?

A

trachoma (eye infection) - not an STI

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18
Q

What are serovars D-K of chlamydia?

A

genital infection

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19
Q

What type of organism is gonorrhoea?

A

gram negative intracellular diplococcus

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20
Q

Where are the primary site of infection of gonorrhoea?

A

mucous membranes of the urethra, endocervix, rectum and pharynx.

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21
Q

What are the differing age categories for males and females in gonorrhoea?

A

men 20-24

women <20

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22
Q

Who is at higher risk of contracting gonorrhoea from an infected partner - males or females?

A

females at higher risk of contracting it from infected male partner (50-90% risk)

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23
Q

23 y/o male presents with green discharge from penis and pain when peeing. He recently (3 days ago) had insertive anal sex with another man whom he has just met.
Diagnosis and when to test?

A

gonorrhoea
urethral infection incubation time is short in men (2-5 days) however test at 14 days since tested at same time as chlamydia using NAATs.

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24
Q

what are the tests for gonorrhoea and when are they done?

A

NAATs = screening
Microscopy if symptomatic
Culture if microscopy +ve or contact of GC

25
Q

What is the 1st line treatment for gonorrhoea?

A

ceftriaxone 1g IM

26
Q

What is the 2nd line treatment of gonorrhoea?

A

cefixime 400mg oral + azithromycin 2g oral

27
Q

What is the typical duration of a primary infection of genital herpes?

A

14-21 days

28
Q

20 y/o female patient presents with blistering of external genitalia, 8/10 pain, vaginal discharge and a tender groin. She reports feeling flu-like this week but is otherwise normally healthy.
Diagnosis?

A

genital herpes

primary infection

29
Q

20 y/o female patient presents with small blisters and ulcers on her external genitalia, they are unilateral and have been present for 4 days. They are mildly sore and sometimes have the feeling of tingling. She has had a similar episode once before, it was worse but she didn’t have any treatment.
Diagnosis?

A

Recurrent infection of genital herpes (probably HSV2)

30
Q

What can you reassure a patient with HSV1 about?

A

they will have cold sores and only experience an attack once every 12-18 months.

31
Q

What is the treatment for HSV?

A

oral acyclovir 400mg tds for 5-7 days

32
Q

What additional treatment would you consider prescribing if a case of genital herpes is particularly painful?

A

topical lidocaine 5% ointment

33
Q

What therapy can you give to reduce the amount of viral shedding?

A

suppressive therapy - aciclovir 2x daily for 12 months

34
Q

What is the most common viral STI in the UK?

A

HPV

35
Q

Anogenital warts are caused by a high-risk HPV strain.

T/F?

A

FALSE

low-risk strain: 6-11

36
Q

Which strain of HPV cause palmoplantar warts?

A

1 & 2

37
Q

Which strain of HPV cause cancers & which ones?

A

16 & 18

cervical, anal, penile, vulval, oropharyngeal

38
Q

What treatment can you give to someone with anogenital warts?

A

podophyllotoxin (Warticon) - cytotoxic
imiquimod - immune modifier
cryotherapy
electrocautery

39
Q

Which treatment option for HPV can be used on all anogenital warts?

A

imiquimod

40
Q

What is the organism behind syphilis?

A

treponema pallidum - subspecies pallidum

41
Q

How is syphilis usually transmitted?

A

sexual contact
trans-placental/during birth
blood transfusions
non-sexual contact (healthcare)

42
Q

Male patient presents having noticed an ulcer on his penis which is painless. He also has non-tender but enlarged lymph nodes in his groin. He reports having sex with a prostitute last week.
Diagnosis and treatment?

A

primary syphilis

2.4 MU Benzathine penicillin x1

43
Q

List some of the signs/symptoms of secondary syphilis.

A

Macular, follicular or pustular rash on palms & soles.
Lesions of mucous membranes.
Generalised lymphadenopathy
Patchy alopecia

44
Q

What is the name for the most highly infectious lesion in syphilis?

A

condylomata lata

45
Q

What technique is used to diagnose syphilis?

A

Primary: dark ground microscopy, PCR, IgM

Secondary: serology (specific & non-specific)

46
Q

What is the treatment for late syphilis?

A

2.4 MU Benzathine penicillin x3

47
Q

What is the organism behind pubic lice?

A

phthirus pubis

48
Q

What is the treatment for pubic lice?

A

malathion lotion

49
Q

26 y/o lady presents with concern about increased, coloured discharge from vagina. She is worried it smells bad.
What is your diagnosis and treatment?

A

bacterial vaginosis

metronidazole 7 days

50
Q

Protozoan parasite which causes purulent, frothy vaginal discharge and irrigation in females.

A

trichomonas vaginalis

51
Q

How would you diagnose this vaginal parasite and treat it?

A

high vaginal swab for microscopy

oral metronidazole

52
Q

What are some predisposing factors to a candida infection?

A

recent antibiotic therapy
high oestrogen levels
poorly controlled diabetes
immunocompromised patients

53
Q

What is the classical PC for candida infection?

A

intensely ITCHY white vaginal discharge

54
Q

What organism is commonest in a candida infection?

A

candida albicans

55
Q

What is the diagnostic test for candida infection?

A

high vaginal swab for culture

56
Q

What treatment options are there for a candida infection?

A

topical clotrimazole pessary or cream

oral fluconazole

57
Q

Which bacteria predominate in normal vaginal flora?

A

lactobacillus species e.g. L. crispatus and L. jensenii

58
Q

What type of organisms are lactobacillus spp.?

A

gram positive bacilli