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What is the definition of GAD (Generalised anxiety disorder)
Generalized anxiety disorder (GAD) is a syndrome of ongoing, uncontrollable, widespread worry
about many events or thoughts that the patient recognizes as excessive and inappropriate.
Symptoms must be present on most days for at least 6 months duration
What are the different types of anxiety disorders?
Generalised Anxiety Disorder (GAD)
Social anxiety disorder
Panic Disorder
Phobias
Separation anxiety
School Phobia
Selective mutism
Biological aetiology of GAD
Genetic: Concordance rate greater for monozygotic twins, 5 times more likely if GAD in 1st degree relatives of GAD patients
Neurophysiological: Dysfunction of autonomic NS, exaggerated responses in amygdala and hippocampus, GABA alterations, serotonin and noradrenaline
Epidemiology of GAD
GAD has a prevalence of 2–4% in the general population.
It is more common in ♀ at a ratio of 2:1.
Environmental aetiology of GAD
Stressful life events: child abuse, relationships, illness, employment or finances
Substance dependence or exposure to organic solvents
RFs for GAD
Predisposing: Genetics, childhood upbringing, personality type and demands for high
achievement. Being divorced. Living alone or as a single parent. Low
socioeconomic status.
Precipitating: Stressful life events such as domestic violence, unemployment, relationship
problems and personal illness (e.g. chronic pain, arthritis, COPD).
Maintaining: Continuing stressful events, marital status, living alone and ways of thinking
which perpetuate anxiety (e.g. ‘What will happen if others notice that I am
anxious?’).
Symptoms of GAD
Breathing difficulty
Choking feeling
Nausea
Dizzy
Fear of dying
Derealisation and depersonalisation
Hot flushes
Numbness
Headaches
Muscle tension
Restlessness
Feeling on edge
Sleep problems
Irratibility
Fear
Worry
Dread
Mood swings
Anger
poor concentration
Fear and its Typical developmental ages
9 months to 3 years: Separation from caregivers, sudden movements, loud noises
3-6 Yrs- animals, the dark, monsters
6-12 Yrs - performance anxiety
12-18 Yrs - Social anxiety, fear of failure/ rejection
Adulthood - illness, death
Definition of Anxiety based on DSM-5
Anxiety disorders are grouped to include disorders that share the same excessive fear and anxiety-related behaviours. The disorders included in this category are:
Separation Anxiety
Selective mutism
School phobia
Generalized
Social
Phobias
Panic disorder
Agoraphobia
PTSD
OCD
What is excoriation?
disorder is characterized by recurrent skin picking resulting in skin lesions. Individuals with excoriation disorder must have made repeated attempts to decrease or stop the skin picking, which must cause clinically significant distress or impairment in social, occupational or other important areas of functioning. The symptoms must not be better explained by symptoms of another mental disorder.
What is trichotillomania
People who have trichotillomania have an irresistible urge to pull out their hair, usually from their scalp, eyelashes, and eyebrows. Trichotillomania is a type of impulse control disorder. People with these disorders know that they can do damage by acting on the impulses, but they cannot stop themselves.
Common features of presentation specific GAD (WATCHERS)
Worry (excessive, uncontrollable)
Autonomic hyperactivity (sweating,
↑ pupil size, ↑ HR)
Tension in muscles/Tremor
Concentration difficulty/Chronic aches
Headache/Hyperventilation
Energy loss
Restlessness
Startled easily/Sleep disturbance (difficulty getting to sleep then intermittent awakening and
nightmares).
ICD-10 criteria for GAD
A. A period of at least 6 months with prominent tension, worry and feelings of apprehension
about everyday events and problems.
B. At least four of the following symptoms with at least one symptom of autonomic arousal:
Symptoms of autonomic arousal: palpitations, sweating, shaking/tremor, dry mouth.
History of GAD?
‘Talk me through a normal day in your life.’ (open question to identify anxiety)
‘Do you ever feel worried with your current state of affairs?’, ‘Do you worry excessively
about minor things on most days of the week?’, ‘Would you say you are an anxious
person?’, ‘Recently, have you been feeling anxious or on edge?’ (generalized worry)
‘Have you noticed any problems with your memory or concentration?’ (↓
concentration)
‘Do you ever lie awake at night worrying, or intermittently wake from sleep?’, ‘Do you
ever have unpleasant dreams or nightmares?’ (sleep disturbance)
Ask about somatic symptoms, e.g. ‘Do you ever feel the sensation of your heart
beating abnormally fast or pounding on your chest?
MSE for GAD
Appearance
and
behaviour
Face looks worried with brow furrowed. Restless with tremor. Sweaty when
you shake their hand. Hyperventilating. Lip biting. Pallor. Tense posture.
Speech Trembling. Slow rate.
Mood Anxious.
Thought Repetitive worrying thoughts. Thoughts may concern personal health,
safety of others or excessive worry about everyday events, e.g.
relationships, finances.
Perception No hallucinations.
Cognition May complain of poor memory and reduced attention/concentration.
Insight May or may not have insight.
Investigation for GAD
Blood tests: FBC (for infection/anaemia), TFTs (hyperthyroidism), glucose
(hypoglycaemia).
ECG: may show sinus tachycardia.
Questionnaires: GAD-2, GAD-7, Beck’s Anxiety Inventory, Hospital Anxiety and
Depression Scale.
DDs for GAD
panic
disorder, specific
phobias, OCD, PTSD.
Depression.
Schizophrenia.
Personality disorder
(e.g. anxious PD,
dependent PD).
Excessive caffeine or alcohol consumption.
Withdrawal from drugs.
Organic: anaemia, hyperthyroidism,
phaeochromocytoma, hypoglycaemia
Biological treatment for GAD
first-line drug treatment of choice is an SSRI (sertraline is recommended)
which has anxiolytic effects. If this does not help an SNRI (e.g. venlafaxine or duloxetine)
can be offered. If both of these are ineffective or not tolerated, pregabalin may be used.
Medication should be continued for at least a year. Benzodiazepines should not be offered
except as short-term measures during crises as they can cause dependence
Psychological management for GAD
Psychoeducational groups are a low intensity form of psychological
intervention. High intensity includes cognitive behavioural therapy and applied relaxation
Social management for GAD
: Include self-help methods (such as writing down worrying thoughts and analysing
them objectively) and support groups. Exercise should be encouraged and may benefit.
NICE stepped care model for interventions with GAD
Step 1: Identification and assessment - Psychoeducation about GAD and active monitoring
Step 2: Low intensity psychological interventions (self help, psychoeducational group-based therapy)
Step 3: High intensity psychological interventions (CBT or applied relaxation)
Step 4: Highly specialist input eg Multi-agency teams, combination of drug and psychological therapies, crisis team
What is the definition of a phobia?
is an intense, irrational fear of an object, situation, place or person that is recognized as
excessive (out of proportion to the threat) or unreasonable.
What is the definition of agoraphobia?
Agoraphobia literally means a ‘fear of the marketplace’. It is a fear of public
spaces or fear of entering a public space from which immediate escape would be difficult in the
event of a panic attack.
What is the definition of a social phobia (social anxiety disorder)
A fear of social situations which may lead to humiliation,
criticism or embarrassment.