still to come Flashcards

1
Q

What is the definition of GAD (Generalised anxiety disorder)

A

Generalized anxiety disorder (GAD) is a syndrome of ongoing, uncontrollable, widespread worry
about many events or thoughts that the patient recognizes as excessive and inappropriate.
Symptoms must be present on most days for at least 6 months duration

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2
Q

What are the different types of anxiety disorders?

A

Generalised Anxiety Disorder (GAD)
Social anxiety disorder
Panic Disorder
Phobias

Separation anxiety

School Phobia

Selective mutism

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3
Q

Biological aetiology of GAD

A

Genetic: Concordance rate greater for monozygotic twins, 5 times more likely if GAD in 1st degree relatives of GAD patients

Neurophysiological: Dysfunction of autonomic NS, exaggerated responses in amygdala and hippocampus, GABA alterations, serotonin and noradrenaline

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4
Q

Epidemiology of GAD

A

GAD has a prevalence of 2–4% in the general population.
It is more common in ♀ at a ratio of 2:1.

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5
Q

Environmental aetiology of GAD

A

Stressful life events: child abuse, relationships, illness, employment or finances
Substance dependence or exposure to organic solvents

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6
Q

RFs for GAD

A

Predisposing: Genetics, childhood upbringing, personality type and demands for high
achievement. Being divorced. Living alone or as a single parent. Low
socioeconomic status.

Precipitating: Stressful life events such as domestic violence, unemployment, relationship
problems and personal illness (e.g. chronic pain, arthritis, COPD).

Maintaining: Continuing stressful events, marital status, living alone and ways of thinking
which perpetuate anxiety (e.g. ‘What will happen if others notice that I am
anxious?’).

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7
Q

Symptoms of GAD

A

Breathing difficulty
Choking feeling
Nausea
Dizzy
Fear of dying
Derealisation and depersonalisation
Hot flushes
Numbness
Headaches
Muscle tension
Restlessness
Feeling on edge
Sleep problems
Irratibility
Fear
Worry
Dread
Mood swings
Anger
poor concentration

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8
Q

Fear and its Typical developmental ages

A

9 months to 3 years: Separation from caregivers, sudden movements, loud noises
3-6 Yrs- animals, the dark, monsters
6-12 Yrs - performance anxiety
12-18 Yrs - Social anxiety, fear of failure/ rejection
Adulthood - illness, death

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9
Q

Definition of Anxiety based on DSM-5

A

Anxiety disorders are grouped to include disorders that share the same excessive fear and anxiety-related behaviours. The disorders included in this category are:
Separation Anxiety
Selective mutism
School phobia
Generalized
Social
Phobias
Panic disorder
Agoraphobia
PTSD
OCD

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10
Q

What is excoriation?

A

disorder is characterized by recurrent skin picking resulting in skin lesions. Individuals with excoriation disorder must have made repeated attempts to decrease or stop the skin picking, which must cause clinically significant distress or impairment in social, occupational or other important areas of functioning. The symptoms must not be better explained by symptoms of another mental disorder.

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11
Q

What is trichotillomania

A

People who have trichotillomania have an irresistible urge to pull out their hair, usually from their scalp, eyelashes, and eyebrows. Trichotillomania is a type of impulse control disorder. People with these disorders know that they can do damage by acting on the impulses, but they cannot stop themselves.

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12
Q

Common features of presentation specific GAD (WATCHERS)

A

Worry (excessive, uncontrollable)
Autonomic hyperactivity (sweating,
↑ pupil size, ↑ HR)
Tension in muscles/Tremor
Concentration difficulty/Chronic aches
Headache/Hyperventilation
Energy loss
Restlessness
Startled easily/Sleep disturbance (difficulty getting to sleep then intermittent awakening and
nightmares).

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13
Q

ICD-10 criteria for GAD

A

A. A period of at least 6 months with prominent tension, worry and feelings of apprehension
about everyday events and problems.
B. At least four of the following symptoms with at least one symptom of autonomic arousal:
Symptoms of autonomic arousal: palpitations, sweating, shaking/tremor, dry mouth.

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14
Q

History of GAD?

A

‘Talk me through a normal day in your life.’ (open question to identify anxiety)
‘Do you ever feel worried with your current state of affairs?’, ‘Do you worry excessively
about minor things on most days of the week?’, ‘Would you say you are an anxious
person?’, ‘Recently, have you been feeling anxious or on edge?’ (generalized worry)
‘Have you noticed any problems with your memory or concentration?’ (↓
concentration)
‘Do you ever lie awake at night worrying, or intermittently wake from sleep?’, ‘Do you
ever have unpleasant dreams or nightmares?’ (sleep disturbance)
Ask about somatic symptoms, e.g. ‘Do you ever feel the sensation of your heart
beating abnormally fast or pounding on your chest?

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15
Q

MSE for GAD

A

Appearance
and
behaviour
Face looks worried with brow furrowed. Restless with tremor. Sweaty when
you shake their hand. Hyperventilating. Lip biting. Pallor. Tense posture.
Speech Trembling. Slow rate.
Mood Anxious.
Thought Repetitive worrying thoughts. Thoughts may concern personal health,
safety of others or excessive worry about everyday events, e.g.
relationships, finances.
Perception No hallucinations.
Cognition May complain of poor memory and reduced attention/concentration.
Insight May or may not have insight.

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16
Q

Investigation for GAD

A

Blood tests: FBC (for infection/anaemia), TFTs (hyperthyroidism), glucose
(hypoglycaemia).
ECG: may show sinus tachycardia.
Questionnaires: GAD-2, GAD-7, Beck’s Anxiety Inventory, Hospital Anxiety and
Depression Scale.

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17
Q

DDs for GAD

A

panic
disorder, specific
phobias, OCD, PTSD.
Depression.
Schizophrenia.
Personality disorder
(e.g. anxious PD,
dependent PD).
Excessive caffeine or alcohol consumption.
Withdrawal from drugs.
Organic: anaemia, hyperthyroidism,
phaeochromocytoma, hypoglycaemia

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18
Q

Biological treatment for GAD

A

first-line drug treatment of choice is an SSRI (sertraline is recommended)
which has anxiolytic effects. If this does not help an SNRI (e.g. venlafaxine or duloxetine)
can be offered. If both of these are ineffective or not tolerated, pregabalin may be used.
Medication should be continued for at least a year. Benzodiazepines should not be offered
except as short-term measures during crises as they can cause dependence

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19
Q

Psychological management for GAD

A

Psychoeducational groups are a low intensity form of psychological
intervention. High intensity includes cognitive behavioural therapy and applied relaxation

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20
Q

Social management for GAD

A

: Include self-help methods (such as writing down worrying thoughts and analysing
them objectively) and support groups. Exercise should be encouraged and may benefit.

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21
Q

NICE stepped care model for interventions with GAD

A

Step 1: Identification and assessment - Psychoeducation about GAD and active monitoring
Step 2: Low intensity psychological interventions (self help, psychoeducational group-based therapy)
Step 3: High intensity psychological interventions (CBT or applied relaxation)
Step 4: Highly specialist input eg Multi-agency teams, combination of drug and psychological therapies, crisis team

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22
Q

What is the definition of a phobia?

A

is an intense, irrational fear of an object, situation, place or person that is recognized as
excessive (out of proportion to the threat) or unreasonable.

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23
Q

What is the definition of agoraphobia?

A

Agoraphobia literally means a ‘fear of the marketplace’. It is a fear of public
spaces or fear of entering a public space from which immediate escape would be difficult in the
event of a panic attack.

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24
Q

What is the definition of a social phobia (social anxiety disorder)

A

A fear of social situations which may lead to humiliation,
criticism or embarrassment.

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25
What is the definition of specific (isolated) phobia:
A fear restricted to a specific object or situation (excluding agoraphobia and social phobia).
26
Aetiology of phobias
Agoraphobia Maintained by avoidance which prevents deconditioning and sets up a vicious cycle of anxiety. Social phobia Uncertain aetiology. Usually begins in late adolescence, an age at which people are concerned about the impression they make on others. Specific phobia Conditioning event in early life, i.e. a frightening experience. Possibly a role for learned behaviour, e.g. from parents
27
Epidemiology of phobic anxiety disorders
Agoraphobia - 25-30 years, 2:1 male to female ration Social phobia - Adolescence - 1:1 Specific phobia - Childhood but can develop later in life- 1:1
28
RFs for phobia's
Aversive experiences (prior experiences with specific objects or situations) Stress and negative life events Other anxiety disorders Mood disorders Substance misuse disorders Family history
29
What are the biological clinical features of phobias?
Tachycardia is the usual autonomic response, however in phobias of blood, injection and injury, a vasovagal response (bradycardia) is produced, commonly leading to fainting (syncope)
30
What are the psychological clinical features of phobias?
Include unpleasant anticipatory anxiety, inability to relax, urge to avoid the feared situation and, at extremes, a fear of dying
31
What is agoraphobia strongly linked to?
panic disorder. Indeed the ICD-10 divides agoraphobia into: agoraphobia with panic disorder and agoraphobia without panic disorder.
32
ICD-10 criteria for agoraphobia
A. Marked and consistently manifest fear in, or avoidance of, at least two of the following: 1. Crowds 2. Public spaces 3. Travelling alone 4. Travelling away from home B. Symptoms of anxiety in the feared situation with at least two symptoms present together (and at least one symptom of autonomic arousal). C. Significant emotional distress due to the avoidance, or anxiety symptoms. Recognized as excessive or unreasonable. D. Symptoms restricted to (or predominate in) feared situation.
33
ICD-10 criteria for social phobia
A. Marked fear (or marked avoidance) of being the focus of attention, or fear of acting in a way that will be embarrassing or humiliating. B. At least two symptoms of anxiety in the feared situation plus one of the following: 1. Blushing 2. Fear of vomiting 3. Urgency or fear of micturition/defecation C. Significant emotional distress due to the avoidance or anxiety symptoms. D. Recognized as excessive or unreasonable. E. Symptoms restricted to (or predominate in) feared situation.
34
ICD-10 criteria for a specific phobia
A. Marked fear (or avoidance) of a specific object or situation that is not agoraphobia or social phobia B. Symptoms of anxiety in the feared situation. C. Significant emotional distress due to the avoidance or anxiety symptoms. Recognized as excessive or unreasonable. D. Symptoms restricted to the feared situation.
35
History questions asked to patients with phobias?
‘What situations cause you anxiety or embarrassment?’ (specific phobia) ‘Do you get symptoms in situations from which escape would be difficult?’, ‘Do you get symptoms in places or situations where help may not be available?’, ‘Do you get symptoms while being in a crowd or travelling on public transport?’ (agoraphobia) ‘Do you ever worry about what people think of you? Does this worry ever lead to you avoiding certain situations?’ (social phobia) ‘Do you avoid any situation because you know you will feel panicky?’ (anticipatory anxiety)
36
What are the features that distinguish phobic anxiety disorders to GAD? (SS, AA, AA)
1. Anxiety occurs in Specific Situations: Agoraphobia – Public transport, supermarkets (especially waiting in queues), cinemas, empty streets. Social phobia – Social gatherings, parties, public speaking, meetings, classrooms, eating in public. 2. There is Anticipatory Anxiety when there is a prospect of encountering the feared situation. 3. There is Attempted Avoidance of circumstances that precipitate anxiety.
37
How would an MSE look for phobias?
ppearance & Behaviour Restless and wanting to escape. Pale, sweaty, hyperventilating. May lose consciousness (blood or injection phobia). Speech May be trembling or they may become speechless. Mood Anxious. Thought Unpleasant feelings towards threat. Fear of situation. Desire to escape. Fear of dying. Insight Poor when feared stimulus present. Good when separated from stimulus.
38
Investigations for phobias
As symptoms occur in a defined situation, diagnosis is usually straightforward with minimal need for investigations. Questionnaires include the Social Phobia Inventory and Liebowitz Social Anxiety Scale.
39
DDs for phobias
Psychiatric: Panic disorder, PTSD, anxious personality disorder, somatoform disorders, adjustment disorder, depression, schizophrenia (may avoid socializing because of paranoid delusions).
40
What are some general points in managing patients with phobias?
Try to establish a good rapport with the patient. Remember, particularly with social phobia, it may have been very challenging for the patient to attend the appointment. Advise avoidance of anxiety-inducing substances, e.g. caffeine. Screen for significant co-morbidities such as substance misuse and personality disorders. Refer to a specialist if there is a risk of self-harm, suicide, self-neglect or significant co-morbidity
41
Management for agoraphobia
CBT is the psychological intervention of choice. The behavioural component includes graduated exposure and desensitization. Graduated exposure techniques such as walking increased distances from home day by day, can be used. SSRIs are the first-line pharmacological agent.
42
What is the management for social phobia?
CBT (individual or group) specifically designed for social phobia. Graduated exposure to feared situations is included both within treatment sessions and as homework. Pharmacological interventions include SSRIs (escitalopram or sertraline), SNRIs (venlafaxine) or if no response to these, a MAOI (moclobemide). Psychodynamic psychotherapy for those who decline CBT or medication.
43
What is the management of specific phobia's?
The mainstay of treatment is exposure either using self-help methods or more formally through CBT. Benzodiazepines may be used as anxiolytics in the short term (due to risk of dependence) for instance if a patient needs an urgent CT scan and they are claustrophobic.
44
What is the definition of a panic disorder?
Panic disorder is characterized by recurrent, episodic, severe panic attacks, which are unpredictable and not restricted to any particular situation or circumstance.
45
What is the aetiology of a panic disorder?
Biological- Genetics: Along with OCD, it is one of the most heritable anxiety disorders. Neurochemical: Post synaptic hypersensitivity to serotonin and adrenaline. Sympathetic nervous system (SNS): Fear or worry stimulates the SNS → ↑cardiac output which can lead to further anxiety. Cognitive- Misinterpretation of somatic symptoms (e.g. fear that palpitations will lead to a heart attack). Environmental- Presence of life stressors can lead to panic disorder.
46
Epidemiology of panic disorders
Panic disorder has a prevalence of 1% in the general population. It is three times more common in ♀. The usual age of onset is late adolescence.
47
RFs for panic disorder
Family history Major life events Age (20–30) Recent trauma Females Other mental disorders White ethnicity Asthma Cigarette smoking Medication
48
ICD-10 criteria for the diagnosis of a panic disorder?
A. Recurrent panic attacks that are not consistently associated with a specific situation or object, and often occur spontaneously. The panic attacks are not associated with marked exertion or with exposure to dangerous or life-threatening situations. B. Characterized by ALL of the following: (1) Discrete episode of intense fear or discomfort; (2) Starts abruptly; (3) Reaches a crescendo within a few minutes and lasts at least some minutes; (4) At least one symptom of autonomic arousal: palpitations, sweating, shaking/tremor, dry mouth; (5) Other symptoms`
49
When do panic symptoms usually peak?
Panic symptoms usually peak within 10 minutes and rarely persist beyond an hour
50
Useful pnemonic for key features of panic disorder is..?
PANICS Disorder Palpitations, Abdominal distress, Numbness/Nausea, Intense fear of death, Choking feeling/Chest pain, Sweating/Shaking/Shortness of breath, Depersonalization/Derealization
51
History questions we ask for a panic disorder
‘Are you generally anxious or are there periods where you are anxiety-free?’ (episodic) ‘Can you predict when these attacks will come on?’ (unpredictable) ‘Have you ever been so frightened that you felt your heart was pounding and that you might die?’ (intense fear and anxiety) ‘Are you worried about your health or any other specific things?’ (major life stressors)
52
MSE for panic disorders
Same as GAD Appearance and behaviour Face looks worried with brow furrowed. Restless with tremor. Sweaty when you shake their hand. Hyperventilating. Lip biting. Pallor. Tense posture. Speech Trembling. Slow rate. Mood Anxious. Thought Repetitive worrying thoughts. Thoughts may concern personal health, safety of others or excessive worry about everyday events, e.g. relationships, finances. Perception No hallucinations. Cognition May complain of poor memory and reduced attention/concentration. Insight May or may not have insight.
53
Investigations for panic disorders
Blood tests: FBC (for infection/anaemia), TFTs (hyperthyroidism), glucose (hypoglycaemia). ECG: may show sinus tachycardia. Questionnaires: GAD-2, GAD-7, Beck’s Anxiety Inventory, Hospital Anxiety and Depression Scale.
54
DDs of panic disorders
Psychiatric: Other anxiety disorders (e.g. generalized anxiety disorder, phobic anxiety disorder), dissociative disorder, bipolar affective disorder, depression, schizophrenia, adjustment disorder. Organic: Phaeochromocytoma, hyperthyroidism, hypoglycaemia, carcinoid syndrome, arrhythmias, alcohol/substance withdrawal
55
Key features of GAD
Age of onset: Variable: adolescence to late adulthood When it occurs: Persistent Assosciated behaviour: Agitation Cognition: Constant worry Associations: Depression
56
Key features of panic disorders
Age of onset : Late adolescence to early adulthood When it occurs: Episodic Assosciated behaviour: Escape Cognition: Fear of symptoms Associations: Depression, agoraphobia, substance misuse
57
Key features of phobic anxiety
Age of onset: Childhood to late adolescence When it occurs: Situational Associated behaviour: Avoidance Cognition: Fear of situation Associations: Substance misuese
58
Management for panic disorders
SSRIs are first-line but if they are not suitable, or there is no improvement after 12 weeks, then a TCA, e.g. imipramine or clomipramine may be considered. Benzodiazepines should not be prescribed. CBT is the psychological intervention of choice, focusing on recognition of panic triggers. Self-help methods include bibliotherapy (giving written information on panic disorder and how to overcome it), support groups and encouraging exercise to promote good health.
59
NICE Stepped care approach to panic disorders
Step 1: Recognition and diagnosis Step 2: Treatment in primary care Step 3: Review and consideration of alternative treatments Step 4: Review and referral to specialist mental health services Step 5: Care in specialist mental health services
60
What is the definition of PTSD?
Is an intense, prolonged, delayed reaction following exposure to an exceptionally traumatic event.
61
What is the definition of abnormal bereavement?
Normal bereavement goes through a number of stages in response to loss of a loved one. Abnormal bereavement has a delayed onset, is more intense and prolonged (>6 months). The impact of their loss overwhelms the individual’s coping capacity.
62
What is the definition of an acute stress reaction:
An abnormal reaction to sudden stressful events
63
What is the definition of an adjustment disorder?
Normal adjustment refers to psychological reactions involved in adapting to new circumstances. Adjustment disorder is when there is significant distress (greater than expected), accompanied by an impairment in social functioning
64
What is the aetiology of PTSD?
Severe assault (e.g. physical or sexual abuse, robbery, mugging). Major natural disaster (e.g. earthquakes, floods). Serious road traffic accident. Observer/survivor of civilian disaster (e.g. acts of terrorism, the Holocaust). Involvement in wars (e.g. World War II, Vietnam War). Freak occurrences (e.g. near drowning when on holiday). Physical torture. Prisoner of war or hostage situation. Hearing about unexpected injury or violent death of a family member or friend.
65
What are the RFs for PTSD?
Exposure to a major traumatic event: Professions at risk (armed forces, police, fire services, journalists, doctors), groups at risk (refugees, asylum seekers). Pre-trauma: Previous trauma, history of mental illness, females, low socioeconomic background, childhood abuse. Peri-trauma: Severity of trauma, perceived threat to life, adverse emotional reaction during or immediately after event. Post-trauma: Concurrent life stressors, absence of social support.
66
Epidemiology of PTSD
Approximately 3% of adults in England suffer from PTSD. 25–30% of individuals experiencing a traumatic event may go on to develop PTSD. It can affect people of all ages, but is more common in ♀ (♀:♂ ratio is 2:1).
67
Clinical features of PTSD
PTSD symptoms must occur within 6 months of the event and can be divided into four categories: 1. Reliving the situation (persistent, intrusive, involuntary): Flashbacks, vivid memories, nightmares, distress when exposed to similar circumstances as the stressor. 2. Avoidance: Avoiding reminders of trauma (e.g. associated people or locations), excessive rumination about the trauma, inability to recall aspects of the trauma. 3. Hyperarousal: Irritability or outbursts, difficulty with concentration, difficulty with sleep, hypervigilance, exaggerated startle response. 4. Emotional numbing: Negative thoughts about oneself, difficulty experiencing emotions, feeling of detachment from others, giving up previously enjoyed activities.
68
ICD-10 criteria for PTSD
A. Exposure to a stressful event or situation of extremely threatening or catastrophic nature (would likely cause distress in almost anyone). B. Persistent remembering (‘reliving’) of the stressful situation. C. Actual or preferred avoidance of similar situations resembling or associated with the stressor. D. Either (1) or (2) 1. Inability to recall some important aspects of the period of exposure to the stressor. 2. Persistent symptoms of increased psychological sensitivity and arousal. E. Criteria B, C & D all occur within 6 months of the stressful event, or the end of a period of stress.
69
History questions for PTSD
‘Has there been any traumatic incident or event in your life recently which may account for how you are feeling?’ (exposure to stressful event) ‘Do you ever get any flashbacks, vivid memories or nightmares about the events that took place?’ (reliving the situation) ‘Do you find yourself constantly thinking about the same thing?’ (rumination) ‘Have you had any problems with sleep since the event?’, ‘Are you feeling more irritable or having trouble concentrating?’, ‘Do you get startled easily?’ (hyperarousal)
70
What are the stages of grief? (DABDA)
Denial Anger Bargaining Depression Acceptance
71
MSE for PTSD
Appearance & Behaviour Hypervigilance (‘on edge’), exaggerated startle reaction, may have features of anxiety or depression, e.g. poor eye contact. Speech Slow rate. Trembling. Non-spontaneous. Mood Anxious. Thought Pessimistic. Reliving or remembering of the event. Perception No hallucinations. May have illusions. Cognition Poor attention and concentration. Insight Good.
72
Investigations for PTSD
Questionnaires: Trauma Screening Questionnaire (TSQ), Post-traumatic diagnostic scale. CT head: if head injury suspected.
73
Differential diagnosis for PTSD?
Psychiatric: Adjustment disorder, acute stress reaction, bereavement, dissociative disorder, mood or anxiety disorders, personality disorder. Organic: Head injury (result of traumatic event), alcohol/substance misuse.
74
What is the definition of an acute stress reaction ? (ICD-10)
Exposure to an exceptional physical or mental stressor (e.g. physical assault, road traffic accident) followed by an immediate onset of symptoms (within one hour). Divided into mild, moderate or severe based on extent of symptoms`
75
What are the possible symptoms of an acute stress reaction and adjustment disorder?
anxiety symptoms (see Section 5.2, GAD), narrowing of attention, apparent disorientation, anger or verbal aggression, despair or hopelessness, uncontrollable or excessive grief. Symptoms must begin to diminish within 8 hours (for transient stressors) or 48 hours (for continued stressors)
76
Adjustment disorder key facts
Identifiable (non-catastrophic) psychosocial stressor (e.g. redundancy, divorce) within one month of onset of symptoms. Symptoms are variable but can be of the types found in the affective disorders or the neurotic disorders (but not severe enough to be classed as a specific psychiatric disorder). The symptoms must be present for less than 6 months.
77
Key points where PTSD where symptoms are present within 3 months of a trauma?
Watchful waiting may be used for mild symptoms lasting <4 weeks. Military personnel have access to treatment provided by the armed forces. Trauma-focused CBT should be given at least once a week for 8–12 sessions. Short-term drug treatment may be considered in the acute phase for management of sleep disturbance (e.g. zopiclone). Risk assessment is important to assess risk for neglect or suicide
78
Management of PTSD where symptoms have been present >3 months after a trauma
All sufferers should be offered a course of trauma-focused psychological intervention. The two options for psychological intervention are CBT and eye movement desensitization and reprocessing (EMDR). The goal of EMDR is to reduce distress in the shortest period of time. It is a form of psychotherapy, with one technique involving eye movements to help the brain process traumatic events (see Section 12.1, Psychotherapies). Drug treatment should be considered when: (1) little benefit from psychological therapy; (2) patient preference not to engage in psychological therapy; (3) co-morbid depression or severe hyperarousal which would benefit from psychological interventions. Paroxetine, mirtazapine, amitriptyline and phenelzine are licensed for treatment of PTSD in the UK. Evidence for paroxetine is weaker than the other three drugs. Practically, amitriptyline and phenelzine are rarely used as a result of their side effects and tolerability.
79
What is the definition of OCD?
is characterized by recurrent obsessional thoughts or compulsive acts, or commonly both. It is ranked by the WHO as one of the top ten most disabling illnesses in terms of impact upon quality of life.
80
What is the definition of obsessions?
Unwanted intrusive thoughts, images or urges that repeatedly enter the individual’s mind. They are distressing for the individual who attempts to resist them and recognizes them as absurd (egodystonic) and a product of their own mind.
81
What are the obsessions with compulsions
Repetitive, stereotyped behaviours or mental acts that a person feels driven into performing. They are overt (observable by others) or covert (mental acts not observable).
82
What are the psychoanalytic and behavioural aetiology of OCD?
Psychoanalytic: Filling the mind with obsessional thoughts in order to prevent undesirable ideas from entering consciousness. Behavioural: Compulsive behaviour is learned and maintained by operant conditioning. The anxiety created by the obsession is reduced by performing the compulsion, and subsequently the need to perform the compulsion is increased.
83
What are the biological aetiology of OCD?
Related to ↓ serotonin and abnormalities of the frontal cortex and basal ganglia. Twin and family studies suggest a genetic contribution to OCD particularly with paediatric onset. Childhood group A beta-haemolytic streptococcal infection may have a role in causing OCD symptoms by setting up an autoimmune reaction which damages the basal ganglia (this is called PANDAS)
84
What other diseases does OCD have strong associations with?
depression (30%), schizophrenia (3%), Sydenham’s chorea, Tourette’s syndrome and anorexia nervosa.
85
What are the ICD-10 criteria for diagnosis of OCD?
A. Either obsessions or compulsions (or both) present on most days for a period of at least 2 weeks. B. Obsessions (thoughts, ideas or images) or compulsions (acts) share a number of features (see Clinical features), ALL of which must be present. C. The obsessions or compulsions cause distress
86
Epidemiology and RFs for OCD
The prevalence of OCD ranges from 0.8–3%. It is most common in early adulthood and is equally common in ♂ and ♀. OCD is more common in the relatives of OCD patients than it is in the general population. Carrying out the compulsive act (e.g. washing) is likely to exacerbate the obsession and is thus a maintaining factor. Developmental factors such as neglect, abuse, bullying and social isolation may have a role
87
Examples of obsessions
Contamination (most common) Fear of harm Excessive concern with order or symmetry Sex, violence, blasphemy, doubt
88
Examples of compulsions
Checking (most common)- gas taps, water taps, doors Cleaning, washing Repeating acts Mental compulsion Hoarding
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What are the features that all obsessions or compulsions must share?
FORD car 1. Failure to resist: At least one obsession or compulsion is present which is unsuccessfully resisted. 2. Originate from patient’s mind: Acknowledged that the obsessions or compulsions originate from their own mind, and are not imposed by outside persons or influences. 3. Repetitive and Distressing: At least one obsession or compulsion must be present which is acknowledged by the patient as excessive or unreasonable. 4. Carrying out the obsessive thought (or compulsive act) is not in itself pleasurable, but reduces anxiety levels.
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What is the OCD cycle?
1. Obsession 2. Anxiety 3. Compulsion 4. Relief
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History of OCD
‘Do you have any distressing thoughts that enter your mind despite trying hard to resist them?’, ‘Is there any unwanted thought that keeps bothering you that you would like to get rid of but cannot?’ (obsessions) ‘Do you worry about contamination with dirt even after washing?’, ‘Do you repeatedly check things you have already done?’, ‘Do you find yourself having to touch, count and arrange things many times?’, ‘Do you wash or clean a lot? Do you check things a lot?’, ‘Are you concerned about putting things in a specific order, or do you get upset by not completing tasks?’ (compulsions) ‘Do your daily activities take a long time to finish?’ (due to carrying out compulsions)
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MSE for patient with OCD
Patient may be on edge (easily startled). May look visibly worried or lost in thought. May be constantly checking doors or fidgety with hands (as they can’t wash them). 112 May demonstrate increasing levels of anxiety if unable to succumb to compulsion (Fig. 5.6.2). Thoughts are unwanted, intrusive and uncomfortable for the patient. Obsessions can be distracting and lead to poor concentration. Insight is usually very good (as they recognize the thoughts are a product of their own mind).
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Investigations for OCD
Yale–Brown obsessive–compulsive scale (Y-BOCS) → 10-item questionnaire with each item graded from 0–4; e.g. Time occupied by obsessive thoughts (0 = none, 4 = extreme, >8 hours/day).
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DDs for OCD
Anorexia + Bulimia Body dysmorphic disorder Anxiety Depressive Hypochondrial disorder Schizophrenia Tourettes Kleptomania Dementia Epilepsy
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2 main strategies for treatment of OCD
1. CBT (including ERP – exposure and response prevention) ERP is a technique in which patients are repeatedly exposed to the situation which causes them anxiety (e.g. exposure to dirt) and are prevented from performing the repetitive actions which lessen that anxiety (e.g. washing their hands). After initial anxiety on exposure, the levels of anxiety gradually decrease. 113 2. Pharmacological therapy SSRIs are the drug of choice in OCD. NICE recommends fluoxetine, fluvoxamine, paroxetine, sertraline or citalopram. Clomipramine is an alternative drug therapy. This can be combined with citalopram in more severe cases. Alternatively, an antipsychotic can be added in with an SSRI or clomipramine
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General points of management for OCD
Psychoeducation, distracting techniques and self-help books can be used. Any potential suicide risk should be identified and managed. Co-morbid depression should be identified and treated. Method of treatment depends upon the degree of functional impairment (Fig. 5.6.3). This ranges from mild (limited impact on ADL) to severe (obsessional slowness that greatly impacts performance).
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What are the departments of CAMHS
Cover two bases Becton Centre( below) And Centenary House (above) Also STAR team is based in the Children's Hospital
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Team/ subspecialities in CAMHS
At Centenary House: SEDATT – Eating Disorders Service Forensic CAMHS Children’s Looked After service Learning Disabilities Becton Centre Learning Disabilities Inpatient – Ruby Lodge Adolescent Inpatient – Sapphire Lodge Children's Inpatient unit – Emerald Lodge Young Children's Day Patient – Amber Lodge
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What is involved in Acute treatment?
Duty team Community intensive team Supportive treatment and recovery
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What does normal development look like?
1st year of life: Loud noises, strangers, new places, heights Preschool 2-6: Being alone, darkness, animals, imaginary creatures School age 4-10: Fears of negative evaluation by others, illness/bodily injury, supernatural phenomenon, natural disaster
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What happens in separation anxiety?
Diagnosis requires a persistence in behaviours for at least a four week period for children and young people. Developmentally inappropriate, visible distress linked to becoming separated from a primary care giver, which leads to pronounced stress and agitation (unable to settle). Older children/adolescents – excessively worry about harm coming to a primary care giver, again leading to pronounced stress and agitation. All ages express considerable reluctance/refusal to leave the primary care giver at any time, including bedtimes and may also have nightmares linked to this anxiety. Most common anxiety disorder under 10 years Older children/adolescents – excessively worry about harm coming to a primary care giver, again leading to pronounced stress and agitation. All ages express considerable reluctance/refusal to leave the primary care giver at any time, including bedtimes and may also have nightmares linked to this anxiety. Most common anxiety disorder under 10 years
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Features of school phobia
Significant Anxiety symptoms Fear of a specific aspect of school Avoidance
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Features of selective mutism
Diagnosis requires symptoms to be present for a period of at least six months and must be occurring most days.  Selective Mutism is related to Social Anxiety Disorder. Children experience difficulty or inability to speak in social contexts or situations
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Emma is an 11 year old girl who has asthma, which is at times poorly controlled. Her Mum says that it is a struggle to get her to take her medication. She generally refuses to go to her GP (the GP has carried out some home visits) and has missed many hospital appointments. What further information would you want to obtain?
How long has this been affecting Emma? Why? Reason for not taking medication/ going to GP Symptoms eg palpitations, nausea, fear of choking etc Other anxieties eg separation, school phobia, GAD Other related conditions eg depression, self harm Family History
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Mum tells you that Emma is afraid of swallowing any tablets, needles, doctors and hospitals. She has had these symptoms for several years. Emma says she is afraid that the tablets will choke her. She is also afraid of needles and a lot of blood, although she is ok if she grazes herself. She feels sick, sweaty and dizzy when in these situations and recently she has started feeling the same when watching Casualty on TV. She is worried about going to secondary school. Generally, Emma eats well and is energetic and happy, but sometimes has difficulty sleeping. She has not self harmed. Her paternal grandmother suffers from agoraphobia. What type of treatment are effective
Psychoeducation Relaxation Systematic desensitisation CBT
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Non - anxious child and anxiety brain
When we have an intense physiological response to a situation or object that we qualify as harmful or dangerous, our brain starts activating certain regions. One of them is the amygdala, which has been said to intervene in emotional responses such as fear and anxiety.  In a none anxious child/young person, the Prefrontal cortex inhibits the Amygdala. The Amygdala is the brain structure that is always on the lookout for threats so it can quickly react and keep us safe. Flight, Fright, Freeze
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How does anxiety affect the brain of a person/ child?
In a anxious child/young person, the Amygdala is hypersensitive and the connections with the Prefrontal Cortex become weaker. With anxiety the Amygdala generates too many false alarms such as; perceiving a safe situation as threatening. Anxiety causes great stress and stress shrinks the Hippocampus. This region of the brain is our memory store. When anxious our accessible memories become limited and only those linked to failure, threat or danger are drawn upon, memories of success, certainty and safety become inaccessible.
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Situations that cause anxiety in children
Academic pressure; Being asked to provide an answer (fear of failure, answer not known) Social pressure; Play times (not knowing how to interact with peers, start a conversation or give the wrong answer and be mocked/bullied. Separation anxiety; Will my mum or dad come back? (fearful of being left alone) Developmental or following trauma such as a bereavement. Health related issues; Will I or someone be sick today? (not wanting to eat, go to public places) Confusing physical anxiety symptoms with illness (impending doom feeling) Crossing a road; The sound of a car triggers a child to panic and run. (Thinking that they may get run over) Family Dynamics; Parental separation, illness, DV/Substance misuse (How will mum or dad be today?)
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Causes to be excluded for anxiety
Hyperthyroidism Arrhythmias Epilepsy – Prodromal symptom Phaeochromocytoma Asthma Illicit Drugs – speed, cocaine, Caffeine - coffee
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What do CAMHS offer if specific therapy is required?
Assessment – checking for co-morbidities ( e.g.ASD) Anxiety management techniques Graded exposure CBT Medication Group Work
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How to do sensory grounding and distraction
Take a deep breath into your belly and slowly breath out Pick a colour and take a look around the space you are in, can you see it? If your mind wanders, gently tell yourself and bring it back to your breath and colour search
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How to do isometric muscle relaxation
Clasp your hands together Squeeze them as tight as you can while trying to pull them apart Hold the tension between your hands like this for 7 seconds Relax and allow your hands and arms to go floppy Now focus on how your hands and arms now feel
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Good distraction techniques for anxiety in childrem
Music (“Have you got your headphones?) Item to distract (attachment – soft toys, fidget spinners, stress ball, resistance bands, mindfulness colouring books, spiral bobbles) Worry space, corner, box or journal Positive statement cards Bubble blowing
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How does CBT work?
. Identify/notice it 2. Challenge it 3. Re-write it 4. Distract 5. Change behaviour