Steven-Johnson syndrome Flashcards
What is steven-Johnson syndrome?
Severe systemic reaction affecting the skin and mucosa
What type of condition is Steven-Johnson syndrome?
Immune-complex-mediated hypersensitivity disorder syndrome
What is Steven-Johnson syndrome usually caused by?
Drug reaction
What is the most severe form of Steven Johnson syndrome?
Toxic Epidermis necrolysis (TENS)
What are the drug causes of Steven-Johnson Syndrome?
penicillin
sulphonamides
lamotrigine, carbamazepine, phenytoin
allopurinol
NSAIDs
oral contraceptive pill
How is Steven-Johnson syndrome diagnosed?
Clincally
What are the main features of Steven-Johnson syndrome?
Maculopapular rash with target lesions
May develop into vesicles or bullae
Nikolsky sign is positive
How does Steven-Johnsons syndrome usually first present?
Usually occurs within a week of taking a drug with symptoms resembling an upper respiratory tract infection
What else can be involved with Steven-Johnsons syndrome?
Mucosal involvement
Mucosal ulceration
What mucosa is typically involved in Steven-Johnson syndrome?
At least 2 of conjunctiva, mouth, urethra, pharynx or gastrointestinal tract
What sign is positive in someone with Steven-Johnson syndrome?
Nikolsky sign in erythematous bits
What is a positive nikolsky sign?
Blisters and erosions appear when the skin is rubbed gently
What is the management of Steven-Johnson syndrome?
Hospital admission is required for supportive treatment
What is the management of Steven-Johnson syndrome?
Hospital admission is required for supportive treatment
What is important to prevent addional complications in someone with Steven-Johnson syndrome?
An ophthalmology referral is important to prevent ocular complications.
