Steroids Flashcards
three categories of steroids
glucocorticosteroids (cortisol)
mineralocorticoids (aldosterone)
sex hormone precursors
physiologic effects of steroids
carbohydrate, lipid, and protein metabolism
cardiovascular function
immune function and inflammation
short acting glucocorticosteroids
hydrocortisone (cortisol)
cortisone
fludrocortisone (mineralcorticoid)
intermediate acting glucocorticosteroids
methylprednisolone
prednisone
triamcinolone
long acting glucocorticosteroids
betamethasone
dexamethasone
uses for steroids
asthma, sarcoidosis, TB, pericarditis, inflammation, adrenal insuficiency, cushing’s syndrome, immunosupression, rheumatic and collagen disorders, preterm labor, cerebral edema, spinal cord injury, cancer
how glucocorticosteroids work
decrease neutrophil migration, decrease prostaglandin and leukotriene synthesis; suppress T lymphocytes, prevent release of inflammatory mediators and histamines
Adverse effects of glucocorticosteroids
osteoporosis, peptic ulceration, changes in mood and behavior, edema, HTN, growth suppression in children, cataracts, glaucoma, increase hair growth, weight gain, acne, negative feedback on hypothalamic axis,
inhaled steroids
all are (C) beclomethasone flunisolide *fluticasone triamcinolone need to rinse mouth after to prevent oral candida; used for asthma and COPD
intranasal steroid uses
rhinitis, nasal polyps
intranasal steroids examples
all are (C) *beclomethasone budesonide flunisolide *fluticasone mometasone triamcinolone
ophthalmic steroids uses
post-op inflammation, conjunctivitis, corneal injuries
ophthalmic steroid examples
all are (C) *Dexamethasone *Prednisolone Fluoromethalone Loteprednol Medrysone Rimexolone
rectal steroids
mostly used for hemorrhoids and ulcerative colitis
hydrocortisone (C)
shampoo steroids
primarily used for seborrheic dermatitis
Fluocinolone (C)
systemic (PO or parenteral) steroids
betamethasone (C) budesonide (C) cortisone acetate (D) dexamethasone (C) hydrocortisone (C) methylprednisolone (C) prednisolone (B) triamcinolone (C)
topical steroid uses
skin diseases characterized by inflammation, hyper proliferation, and/or immunologic phenomenon, burns, pruritis
ex allergic contact dermatitis, eczema, psoriasis
topical steroids ADRs
acne eruption, atrophy of dermis, delayed wound heeling, secondary infection, contact dermatitis
low potency topical steroids
alclometasone dipropionate desonide fluocinolone acetonide hydrocortisone hydrocortisone acetate
intermediate potency topical steroids
betamethasone dipropionate 0.05% lotion betamethasone valerate 0.1% cream clocortolone pivalate desoximetasone cream fluocinolone acetonide flurandrenolide fluticasone propionate hydrocortisone butyrate hydrocortisone valerate mometasone furoate prednicarbate triamcinolone acetonide 0.025%, 0.1%
hi potency topical steroids
amcinonide betamethasone diprop 0.05% cream betamethasone valerate desoximetasone 0.05% gel, 0.25% cream, oint fluocinonide halcinonide triamcinolone acetonide 0.5%
very hi potency steroids
betamethasone diprop 0.05% oint
clobetasol propionnate
diflorasone diacetate
halobetasol propionate
