Steroids

Question 1

What is considered the natural steroid?

Answer 1

Cortisol

Question 2

What type of hormone is an analog estradiol?

Answer 2

Testosterone

Question 3

What is the back bone of a steroid made of?

Answer 3

4 rings and 17 carbons

Question 4

What is secreted from the middle cortex/fasciculata?

Answer 4

Glucocorticoids and Hydrocortisone

Question 5

In the outer cortex of the adernal gland, what happens to sodium, potassium and BP?

Answer 5

Increase SODIUM RETENTION

Increase POTASSIUM EXCRETION

Increase BP

Question 6

Which endogenous steroid is functional for homeostasis?

Answer 6

Glucocorticoids

Question 7

In order to get a higher dose than hydrocortisone, what drug would you use?

Answer 7

Cortisone

Question 8

What protein product will inhibit PLA2?

Answer 8

Lipocortin

Question 9

What steroid inhibits the HPA axis?

Answer 9

Cortisol

Question 10

What does the Hypothalamus release, whose function is to make the Anterior pituitary gland release ACTH?

Answer 10

Corticotropin

Question 11

At 8 am, there is the highest amount of glucocorticoid generation but when is it the lowest?

Answer 11

2 to 4 hours after sleep initiation

Question 12

What PG’s increase in the form of sensitizing nerves to pain?

Answer 12

PGE2 and PGF2a

Question 13

What type of drug will inhibit a Leukotriene?

Answer 13

Steroid

Question 14

What type of cell is involved in tissue remodeling? Which drug can inhibit this cell causing dry eye’s?

Answer 14

Fibroblasts and Steroids cause dry eyes

Question 15

What mineralcorticosteroid is involved in fluid retention?

Answer 15

Aldosterone

Question 16

What is released by WBC’s during protrusion ?

Answer 16

Chemokine

Note: Chemokine is a pro-inflammatory mediator

Question 17

If a pt. has swelling of the optic nerve head due to elevated CSF and you find out that your pt has psuedotumor cerebri. What is the secondary effect in this event?

Answer 17

Inflammation

Question 18

In Addison’s disease, what is the primary cause of the this problem occuring?

Answer 18

Chronic Adrenal cortex HYPOsecretion

Question 19

In Cushings disease, what is the primary cause of the this problem occuring?

Answer 19

Excess ACTH

Question 20

What type of disorder can remain dormant as a cyst for life in respiratory tract and can get aggravated by Steroids?

Answer 20

TB

Question 21

What type of NSAID enhances metabolism of a steroid but is also used for treating Gout?

Answer 21

Phenylbutazone

Question 22

Which type of steroid has higher potential to cause cataracts?

Answer 22

Ketone

Question 23

What type of topical steroid contains less BAK and a more neutral pH compared to suspensions?

Answer 23

Loteprednol etabonate (Lotemax Gel)

Question 24

What is the only type of emulsion topical steroid with maximum strength?

Answer 24

Difluprednate

Question 25

Which maximum strength suspension, also has a solution based generic?

Answer 25

Prednisolone Acetate

Question 26

What is the only ester based topical drug in eye care?

Answer 26

Loteprednol Etabonate

Question 27

What type of Herpes is an immediate steroid indication?

Answer 27

Zoster or inactived version of Simplex

Question 28

What are two major ocular adverse effects of a steroid?

Answer 28

Increased IOP and Mydriasis

Question 29

What drug is dose dependent for reducing corneal inflammation?

Answer 29

PreForte