Anti-Effectives Flashcards
Drug of choice for pregnant women with a bacterial infection.
Tobramycin - (Tobrex or TobraDEX)
Aminoglycoside used for severe eye infections and cannot use while operating heavy machinery
Gentamycin
Major side effect of Gentamycin and causes increase of the intragranial pressure
Pseudotumor cerebri
Aminoglycosides cause weakness in what type of autoimmune neuromuscular disorder
Myasthenia Gravis
What type of hypersensitivity is related to Neomycin usage?
Type 4
What 2 drugs inactivate Aminoglycosides?
Penicillins and Cephlasporins
What is the best pregnant drug used for Blepharitis?
Azithromycin (Best used for Preg B)
What type of drug will increase levels of Theophylline?
Macrolides
Note: Rise in Theophylline will increase metabolism
What bacteriostatic drug will cause grey baby syndrome?
Chloramphenicol
Note: Bacteriostatic
Which drug type becomes more Gram + as new generations get created?
Fluoroquinolones
What type of FQ is great for Bacterial Keratitis?
Levofloxacin
What is the best type of FQ to use on Paediatric infections?
Moxifloxacin
What type of FQ causes white corneal precipitates?
Ciprofloxacin
What type of drug inhibits Dihydropteroate synthase?
Sulfonamides - acts as a competitive antagonist
What drug inhibits Dihydrofolate reductase and doesn’t aloow THF to be created?
Trimethoprine or Pyrimethamine
What drug is the first line of defense against MRSA?
Trimethoprine
True or False. Sulfonamides are structural analogs of Maba?
False. They are analogs of PABA
What combo drug is used to treat taxoplasmosis?
Sulfadiazine and Pyrimethamine
What type of drug has an adverse effect which causes myopia?
Sulfonamides
What do you not ingest when taking a TC?
Milk or Anti - acid
Divalent cation binding will occur
What drug is associated with infants developing poor teeth?
Doxycycline
Used for: MAC
Meibianitis/Meibomian Gland Stasis
Acne Roseca
Chlamydia
What are TC used for primarily in Optometric setting?
Lid Infections
If a pt. has a lung problem, what is the best anti-inflammatory drug for this use?
Tetracycline
What drug type causes increased warfarin effect and anti coagulation?
Tetracycline
What is very common adverse reaction in children?
Pseudotumor Cerebri - Increased intercranial pressure
What is the best drug to use for children with acute bacterial infection?
Polymixin B and Trimethoprim
What type toxicity could Polymixin B generate?
Nephrotoxicity
What are 4 main type of anti effectives that are GM - ?
PAFT
Polymixin B
AG’s
FQ
TC
What are the 2 dose dependent drugs?
AG and FQ
MRSA is resistant to what PCN the most?
Methicillin
What type of drug has an adverse rxn to Vit K and Hemophilia?
Cephalosporins
Note: Destroy’s intestinal microflora
Why is Bacitracin not used orally?
Due to Nephrotoxicity
What drug causes Red Man syndrome?
Vancomycin
When should you use a steroid?
When you see inflammation near the limbus
In regards to drug resistance, what type of drugs should be selected?
Narrow spectrum
and
Older agents
What is the most common cold virus influenced by an eye infection?
Adenovirus
What type of drug fo you not give Herpes pts.’s?
Steroids
What is the first line of therapy for HSV1 and HSV2 Keratitis?
Trifluridine (Pyrimidine)
What is the anti viral drug of choice for Cytomegalovirus?
Acyclovir
What drug is used for acutre herpetic keratitis?
Ganciclovir
What is the only antifungal used by Optometrists?
Natamycin
What type of antifungal impairs cyp450?
Azole
What is the main adverse rxn of Azoles?
Hepatotoxicity
Use Echinocandins
What is the great imposter?
Acanthamoeba
Use: Bigunaides
