Anti-Effectives Flashcards

1
Q

Drug of choice for pregnant women with a bacterial infection.

A

Tobramycin - (Tobrex or TobraDEX)

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2
Q

Aminoglycoside used for severe eye infections and cannot use while operating heavy machinery

A

Gentamycin

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3
Q

Major side effect of Gentamycin and causes increase of the intragranial pressure

A

Pseudotumor cerebri

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4
Q

Aminoglycosides cause weakness in what type of autoimmune neuromuscular disorder

A

Myasthenia Gravis

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5
Q

What type of hypersensitivity is related to Neomycin usage?

A

Type 4

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6
Q

What 2 drugs inactivate Aminoglycosides?

A

Penicillins and Cephlasporins

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7
Q

What is the best pregnant drug used for Blepharitis?

A

Azithromycin (Best used for Preg B)

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8
Q

What type of drug will increase levels of Theophylline?

A

Macrolides

Note: Rise in Theophylline will increase metabolism

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9
Q

What bacteriostatic drug will cause grey baby syndrome?

A

Chloramphenicol

Note: Bacteriostatic

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10
Q

Which drug type becomes more Gram + as new generations get created?

A

Fluoroquinolones

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11
Q

What type of FQ is great for Bacterial Keratitis?

A

Levofloxacin

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12
Q

What is the best type of FQ to use on Paediatric infections?

A

Moxifloxacin

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13
Q

What type of FQ causes white corneal precipitates?

A

Ciprofloxacin

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14
Q

What type of drug inhibits Dihydropteroate synthase?

A

Sulfonamides - acts as a competitive antagonist

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15
Q

What drug inhibits Dihydrofolate reductase and doesn’t aloow THF to be created?

A

Trimethoprine or Pyrimethamine

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16
Q

What drug is the first line of defense against MRSA?

A

Trimethoprine

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17
Q

True or False. Sulfonamides are structural analogs of Maba?

A

False. They are analogs of PABA

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18
Q

What combo drug is used to treat taxoplasmosis?

A

Sulfadiazine and Pyrimethamine

19
Q

What type of drug has an adverse effect which causes myopia?

A

Sulfonamides

20
Q

What do you not ingest when taking a TC?

A

Milk or Anti - acid

Divalent cation binding will occur

21
Q

What drug is associated with infants developing poor teeth?

A

Doxycycline

Used for: MAC
Meibianitis/Meibomian Gland Stasis
Acne Roseca
Chlamydia

22
Q

What are TC used for primarily in Optometric setting?

A

Lid Infections

23
Q

If a pt. has a lung problem, what is the best anti-inflammatory drug for this use?

A

Tetracycline

24
Q

What drug type causes increased warfarin effect and anti coagulation?

A

Tetracycline

25
Q

What is very common adverse reaction in children?

A

Pseudotumor Cerebri - Increased intercranial pressure

26
Q

What is the best drug to use for children with acute bacterial infection?

A

Polymixin B and Trimethoprim

27
Q

What type toxicity could Polymixin B generate?

A

Nephrotoxicity

28
Q

What are 4 main type of anti effectives that are GM - ?

A

PAFT

Polymixin B
AG’s
FQ
TC

29
Q

What are the 2 dose dependent drugs?

A

AG and FQ

30
Q

MRSA is resistant to what PCN the most?

A

Methicillin

31
Q

What type of drug has an adverse rxn to Vit K and Hemophilia?

A

Cephalosporins

Note: Destroy’s intestinal microflora

32
Q

Why is Bacitracin not used orally?

A

Due to Nephrotoxicity

33
Q

What drug causes Red Man syndrome?

A

Vancomycin

34
Q

When should you use a steroid?

A

When you see inflammation near the limbus

35
Q

In regards to drug resistance, what type of drugs should be selected?

A

Narrow spectrum
and
Older agents

36
Q

What is the most common cold virus influenced by an eye infection?

A

Adenovirus

37
Q

What type of drug fo you not give Herpes pts.’s?

A

Steroids

38
Q

What is the first line of therapy for HSV1 and HSV2 Keratitis?

A

Trifluridine (Pyrimidine)

39
Q

What is the anti viral drug of choice for Cytomegalovirus?

A

Acyclovir

40
Q

What drug is used for acutre herpetic keratitis?

A

Ganciclovir

41
Q

What is the only antifungal used by Optometrists?

A

Natamycin

42
Q

What type of antifungal impairs cyp450?

A

Azole

43
Q

What is the main adverse rxn of Azoles?

A

Hepatotoxicity

Use Echinocandins

44
Q

What is the great imposter?

A

Acanthamoeba

Use: Bigunaides