NSAIDS and Sulfurs Flashcards
What 3 aspects of physiological pain?
Tachypnea, Systemic HTN and Tachycardia
What pathway does Anesthesia interrupt?
Efferent pathway
What stimulates pain fibers?
BPNH
Bradykinin, Potassium ions, NorEpi and Histamine
What does allodynia?
Decrease pain tolerance due to increased pain fiber sensitization
What induces Endorphins?
TCAD’s
What PG is meant as a pain mediator?
PGF2a
What do Leukotrienes do in regards to inflammation?
Bronchoconstriction, enhance histamine effects and dilate vessels
What does TXA2 do in the inflammatory system?
Platlet aggregation and vasoconstriction
What type of fatty acid will lower a seizure threshold?
Omega 6
What is the constitutive enzyme?
COX 1 (TXA2 production)
What is the inducible enzyme?
COX 2 (Prostacyclin)
What is the ASA dose you give to an individual who has pain?
160-325 mg
Which drug has the highest toxicity and least COX 2 selectivity?
Ketorolac
Which type of Salicylate, is cox 2 selective?
Diclofenac
What Salicylate is cox 1 selective?
Ketorolac