NSAIDS and Sulfurs Flashcards

1
Q

What 3 aspects of physiological pain?

A

Tachypnea, Systemic HTN and Tachycardia

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2
Q

What pathway does Anesthesia interrupt?

A

Efferent pathway

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3
Q

What stimulates pain fibers?

A

BPNH

Bradykinin, Potassium ions, NorEpi and Histamine

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4
Q

What does allodynia?

A

Decrease pain tolerance due to increased pain fiber sensitization

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5
Q

What induces Endorphins?

A

TCAD’s

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6
Q

What PG is meant as a pain mediator?

A

PGF2a

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7
Q

What do Leukotrienes do in regards to inflammation?

A

Bronchoconstriction, enhance histamine effects and dilate vessels

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8
Q

What does TXA2 do in the inflammatory system?

A

Platlet aggregation and vasoconstriction

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9
Q

What type of fatty acid will lower a seizure threshold?

A

Omega 6

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10
Q

What is the constitutive enzyme?

A

COX 1 (TXA2 production)

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11
Q

What is the inducible enzyme?

A

COX 2 (Prostacyclin)

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12
Q

What is the ASA dose you give to an individual who has pain?

A

160-325 mg

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13
Q

Which drug has the highest toxicity and least COX 2 selectivity?

A

Ketorolac

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14
Q

Which type of Salicylate, is cox 2 selective?

A

Diclofenac

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15
Q

What Salicylate is cox 1 selective?

A

Ketorolac

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16
Q

What drug is associated with Reye’s syndrome?

A

Aspirin

17
Q

What type of toxicity can tylenol provide?

A

Hepatic (Liver)

18
Q

What NSAID is used for Corneal Pain?

A

Nepafenac

19
Q

What drug is used for Allergic Conjunctivitis?

A

Ketorolac

20
Q

NSAID’s vs. Steroids, which one effects HPA effects?

A

Steroids

Causes cataracts

21
Q

True or False. Narcotics mimic endorphins

A

True

22
Q

What type of drug is used for dry eye therapy?

A

Retasis (Cyclosporine)

23
Q

Which type of PG decreases acid secretion?

A

PGI2

24
Q

Which type of opoid has the lowest abuse and dependancy risk?

A

Hydrocodone

25
Q

Which drug doesn’t have a huge dose but causes the greatest effect out of all the Opoids?

A

Fantanyl

26
Q

Which is the most mechanism is associated with respiratory depression?

A

Mu2 - This is the most common death for drug abusers

27
Q

Is it okay to give your pt. an opoid whom have had history of type 1 hypersensitivity?

A

No you do not.