NSAIDS and Sulfurs

Question 1

What 3 aspects of physiological pain?

Answer 1

Tachypnea, Systemic HTN and Tachycardia

Question 2

What pathway does Anesthesia interrupt?

Answer 2

Efferent pathway

Question 3

What stimulates pain fibers?

Answer 3

BPNH

Bradykinin, Potassium ions, NorEpi and Histamine

Question 4

What does allodynia?

Answer 4

Decrease pain tolerance due to increased pain fiber sensitization

Question 5

What induces Endorphins?

Answer 5

TCAD’s

Question 6

What PG is meant as a pain mediator?

Answer 6

PGF2a

Question 7

What do Leukotrienes do in regards to inflammation?

Answer 7

Bronchoconstriction, enhance histamine effects and dilate vessels

Question 8

What does TXA2 do in the inflammatory system?

Answer 8

Platlet aggregation and vasoconstriction

Question 9

What type of fatty acid will lower a seizure threshold?

Answer 9

Omega 6

Question 10

What is the constitutive enzyme?

Answer 10

COX 1 (TXA2 production)

Question 11

What is the inducible enzyme?

Answer 11

COX 2 (Prostacyclin)

Question 12

What is the ASA dose you give to an individual who has pain?

Answer 12

160-325 mg

Question 13

Which drug has the highest toxicity and least COX 2 selectivity?

Answer 13

Ketorolac

Question 14

Which type of Salicylate, is cox 2 selective?

Answer 14

Diclofenac

Question 15

What Salicylate is cox 1 selective?

Answer 15

Ketorolac

Question 16

What drug is associated with Reye’s syndrome?

Answer 16

Aspirin

Question 17

What type of toxicity can tylenol provide?

Answer 17

Hepatic (Liver)

Question 18

What NSAID is used for Corneal Pain?

Answer 18

Nepafenac

Question 19

What drug is used for Allergic Conjunctivitis?

Answer 19

Ketorolac

Question 20

NSAID’s vs. Steroids, which one effects HPA effects?

Answer 20

Steroids

Causes cataracts

Question 21

True or False. Narcotics mimic endorphins

Answer 21

True

Question 22

What type of drug is used for dry eye therapy?

Answer 22

Retasis (Cyclosporine)

Question 23

Which type of PG decreases acid secretion?

Answer 23

PGI2

Question 24

Which type of opoid has the lowest abuse and dependancy risk?

Answer 24

Hydrocodone

Question 25

Which drug doesn't have a huge dose but causes the greatest effect out of all the Opoids?

Answer 25

Fantanyl

Question 26

Which is the most mechanism is associated with respiratory depression?

Answer 26

Mu2 - This is the most common death for drug abusers

Question 27

Is it okay to give your pt. an opoid whom have had history of type 1 hypersensitivity?

Answer 27

No you do not.