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MRCOG > Steroid synthesis > Flashcards

Steroid synthesis Flashcards

1
Q

What causes cholesterol transport into the mitochondria?

A

StAR protein

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2
Q

What is the first step in steroid synthesis?

A

Cholesterol to pregnenelone by CYP11A1

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3
Q

Describe the formation of corticosterone from pregnenelone

A

Pregnenelone -> progesterone by 3bHSD -> Deoxycorticosterone by 21OHase -> Corticosterone

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4
Q

Describe the formation of cortisol from pregnenelone

A

Pregnenelone -> 17OH pregnenelone by 17OHase -> 17OH corticosterone by 3bHSD -> 11-deoxycortisol by 21OHase -> cortisol

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5
Q

Describe the formation of testosterone from pregnenelone

A

Pregnenelone -> 17OH pregnenelone by 17OHase -> DHEAs by 17OHase -> androstenedione by 3bHSD -> testosterone by 17bHSD

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6
Q

How does oestrogen form from pregnenelone?

A

First testosterone -> oestradiol by aromataseWha

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7
Q

How is arachidonic acid formed?

A

Breakdown of phospholipid membrane by phospholipase A2

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8
Q

Describe the fate of arachidonic acid

A

Can go down COX pathway -> metabolised by COX1+2 to form PGH2 -> synthases to form PGD/E/F, prostacyclin (PGI2) or TXA

or can be metabolised by lipo-oxygenases to form leukotrienes

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MRCOG (7 decks)

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