steroid hormones and vitamin D

Question 1

3 beta hydroxysteroid dehydrogenase leads to

Answer 1

inability to make progesterone from pregnenolone, thus can’t make any steroids

salt excretion in urine

female- like genitalia

Question 2

a deficiency in 17 alpha hydroxylase results in

Answer 2

in ability to make cortisol and sex hormones

and an increase in production of mineralcorticosteriods causing sodium and fluid retention and thus hypertension

female -like genitalia

Question 3

a deficiency in 21 alpha hydroxylase results in

Answer 3

inability to make mineralcorticosteriods or glucocorticoids

over production of androgens leading to masculinization of external genitalia in females and early development in males

Question 4

a deficincy in 11 beta 1 hydroxylase results in

Answer 4

decrease in serum aldosterone cortisol and corticosterone

increased deoxycorticosterone causing fluid retention ( b/c it suppresses renin-angiotensin systems, causing low renin and hypertension)

overpoduction of androgens causing masculinization of girls and early development in males