Blood Lipoproteins

Question 0

What does lcat do?

Answer 0

Transfers fatty acids from lecithin to cholesteryl esters which is involved in the maturation if HDL

Question 1

The most abundant apolipoprotein is?

Answer 1

Apo A1

Question 2

Which apoprotein is unique to chylomicrons and where is this apoprotein synthesized?

Answer 2

Apo B48, the intestines

Question 3

What encodes Apo B100?

Answer 3

Apo B48

Question 4

What does Apo E do?

Answer 4

Mediates the hepatic uptake if chylomicrons and VLDL remnants and IDL.

Also responsible for the clearance of intestinal derived lipoproteins after a meal and clearance of VLDL and IDL before they are converted to LDL

Question 5

Apo C II does what to LPL?

Answer 5

Activates LPL

Question 6

Apo C III Does what to LPL?

Answer 6

Inhibits LPL

Question 7

What does Apo A II do?

Answer 7

Activates LPL and inhibits LCAT-May be proatherogenic

Question 8

What does Apo B 100 do?

Answer 8

Binds to lipids provides by MTP to assemble VLDL

Question 9

What does MTP do?

Answer 9

Loads Apo B 48 with lipid

Question 10

Which Apolipoprotein is not recognized by the LDL receptor?

Answer 10

APO B48

Question 11

What is the most common Apo E protein?

Answer 11

Apo E3

Question 12

Which ApoE is related to Alzheimer’s?

Answer 12

ApoE4

Question 13

Which ApoE is a risk factor for type III hyperlipidemia ( an increase of chylomicrons and VLDL )?

Answer 13

ApoE 2

Question 14

What is inside a nascent chylomicron?

Answer 14

Apo B 48, lots of triglycerides, and less cholesterol and Fat soluble Vitamins and cholesterol esters,

Question 15

Which Apolipoprotein (class) is recognized by receptor in the hepatic cells?

Answer 15

Apo E

Question 16

Which is the least common Apo E?

Answer 16

ApoE 2: it causes hyperlipidemia /huperlipoproteinemia

Question 17

LDL binds to LDL receptors via which Apolipoprotein ?

Answer 17

Apo B 100

Question 18

What us the rate controlling enzyme in cholesterol synthesis?

Answer 18

HMG-CoA reductase

Question 19

Too much cholesterol can diminish ________?

Answer 19

The Amount ie the expression of LDL receptor in the liver

Question 20

Too little cholesterol increases________?

Answer 20

Amount ie the expression of LDL receptor

Question 21

A defect in Apo B 100 or Deficiency In LDL can cause?

Answer 21

Type II hyperlipidemia

Question 22

An increase in cholesterol ____ HMG CoA reductase,_____ LDL receptor,_____ACAT.

Answer 22

Decrease HMG CoA reductase

Decrease LDL receptor

Increase ACAT

Question 23

ACAT increases if cholesterol _______

Answer 23

Increases intracellularly

Question 24

What does ACAT do?

Answer 24

Convert cholesterol to cholesterol ester

Question 25

What does nascent HDL do?

Answer 25

Reverse cholesterol transport: Take up cholesterol from peripheral tissues and return it to the liver as cholesterol esters Hence they are referred to as good cholesterol

Question 26

LCAT is activated by?

Answer 26

Apo A1

Question 27

How do scavenger receptors (class B 1) internalize cholesterol esters?

Answer 27

NOT by endocytosis but by dome other method Other classes like class A found In macrophages do endocytosis

Question 28

Macrophages consume excess ______ and become ______

Answer 28

LDL Foam cells