Steriods Flashcards
physiological effects of cortisol
catabolises tissues to release amino acids
reduces bone formation and enhances resorption
increases glucogenesis and causes insulin resistance
mineralocorticoid effects on blood pressure
effects on mood
breaks down fats to fatty acids and glycerol
modulates immune system
release of catecholamines
addisons disease symptoms
hypotension
hyperpigmentation
fatigue
muscle weakness
hypoglycaemia
low Na/raised K
nausea and vomiting
addisonian crisis
collapse
hypoglycaemia
abdo pain
d and v
cushings disease symptoms
truncal obesity
moon face
striae
hypertension
hirsutism
osteoporosis
diabetes - increased blood glusoce levels
action of steroids
cortisone binds to receptor internalised by cell
blocks transcriptions of inflammatory cytokines and adhesion molecules and increases anti-inflammatory proteins
inhibits phagocytosis - increases risk of infection
suppresses COX-2 synthesis
administration of steroids
tablets
topical
inhaler
intravenous
joint injection
eye drops
MSK side effects of steroids
myopathy
osteoporosis
osteonecrosis
tendon rupture in localised steroid injectons
opthalmic side effects of steroids
cataracts
glaucoma
GI side effects of steroids
peptic ulcer disease
pancreatitis
perforation
steatohepatitis
CNS side effects of steroids
psychosis
depression
mood and sleep ditrubance
dermatological side effecrs of steroids
acne
striae
alopecia
bruising
skin atrophy
CV side effects of steroids
fluid retention
altered lipid profiles
arrhythmias
athersclerosis
steroid effects on glucose
hyperglycaemia
insulin resistance
steroid effects on proteins
catabolism in muscle and bone
steroid effects on electrolytes
Na retention
K loss
