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PHARMACOLOGY > STEPS IN AUTONOMIC TRANSMISSION: EFFECTS OF SOME DRUGS. > Flashcards

STEPS IN AUTONOMIC TRANSMISSION: EFFECTS OF SOME DRUGS. Flashcards

1
Q

Action potential propagation
- Block voltage-gated channel; Block conduction

A

Local anesthetics
Tetrodotoxin
Saxitoxin

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2
Q

Transmitter synthesis
- Block uptake of choline and slow ACh synthesis

A

Helicholiniums

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3
Q

Transmitter synthesis
Inhibits tyrosine hydroxylase and blocks synthesis of catecholamines

A

a-Methyltyrosine

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4
Q

Transmitter storage
Prevents storage, depletes

A

Vesamicol
Reserpine, Tetrabenazine

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5
Q

Transmitter Release
- Modulate release

A

Many3

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6
Q

Transmitter Release
- Reduces transmitter release

A

ω-Conotoxin GVIA4

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7
Q

Transmitter Release
- Modulates transmitter release by altering calcium influx/release

A

Domoic acid

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8
Q

Transmitter Release
- Prevents ACh release

A

Botulinum toxin

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9
Q

Transmitter Release
- Causes explosive transmitter release

A

α-Latrotoxin5

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10
Q

Transmitter Release
- Promote transmitter release

A

Tyramine, amphetamine

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11
Q

Transmitter reuptake after release
- Inhibit uptake; increase transmitter effect on postsynaptic receptors

A

Cocaine,
Tricyclic antidepressants,
SNRI antidepressants

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12
Q

Receptor activation or blockade
- Binds and activates α receptors; causes contraction

A

Norepinephrine

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13
Q

Receptor activation or blockade
- Binds α receptors; prevents activation

A

Phentolamine

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14
Q

Receptor activation or blockade
- Binds β receptors; activates adenylyl cyclase

A

Isoproterenol

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15
Q

Receptor activation or blockade
- Binds β receptors; prevents activation

A

Propranolol

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16
Q

Receptor activation or blockade
- Binds nicotinic receptors; opens ion channel in postsynaptic membrane

17
Q

Receptor activation or blockade
- Prevents activation of nicotinic receptors

A

Tubacurarine

18
Q

Receptor activation or blockade
- Binds and activates muscarinic receptors

A

Betanechol

19
Q

Receptor activation or blockade
- Binds muscarinic receptors; prevents activation

20
Q

Enzymatic inactivation of transmitter
- Inhibits enzyme; prolongs and intensifies transmitter action after release

A

Neostigmine

21
Q

Enzymatic inactivation of transmitter

A

Tranylcypromine

PHARMACOLOGY (7 decks)

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