CHAPTER 10 SYMPATHETIC DRUGS Flashcards
ALPHA-ADRENOCEPTOR ANTAGONISTS
- Irreversibly blocks α1 and α2
* indirect baroreflex activation
- Pheochromocytoma
* high catecholamine states
Phenoxybenzamine
ALPHA-ADRENOCEPTOR ANTAGONISTS
- Reversibly blocks α1 and α2
- Pheochromocytoma
Phentolamine
ALPHA-ADRENOCEPTOR ANTAGONISTS
- Block α1, but not α2
- Hypertension * benign prostatic
hyperplasia
Prazosin
Doxazosin
* Terazosin
ALPHA-ADRENOCEPTOR ANTAGONISTS
- Slightly selective for α1A
- Benign prostatic hyperplasia
Tamsulosin
ALPHA-ADRENOCEPTOR ANTAGONISTS
- Blocks α2 * elicits increased
central sympathetic activity
* increased norepinephrine
release
- Male erectile dysfunction
* hypotension
Yohimbine
ALPHA-ADRENOCEPTOR ANTAGONISTS
- β > α1 block
- Hypertension
Labetalol
BETA-ADRENOCEPTOR ANTAGONISTS
- Block β1 and β2
- Hypertension
* angina pectoris
* arrhythmias
* migraine
* hyperthyroidism
* glaucoma (topical ———-)
Propranolol
Nadolol
* Timolol
BETA-ADRENOCEPTOR ANTAGONISTS
- Block β1 > β2
- Angina pectoris
* hypertension
* arrhythmias
* glaucoma (topical —–)
Metoprolol
Atenolol
Betaxolol
Nebivolol
BETA-ADRENOCEPTOR ANTAGONISTS
- Blocks β2 > β1
- No clinical indication
Butoxamine
BETA-ADRENOCEPTOR ANTAGONISTS
- β > α1 block
- Heart failure
Carvedilol
Medroxalol
* Bucindolol
BETA-ADRENOCEPTOR ANTAGONISTS
- β1 > β2
- Rapid control of BP and
arrhythmias, thyrotoxicosis,
and myocardial ischemia
intraoperatively
- Esmolol
BETA-ADRENOCEPTOR ANTAGONISTS
Drugs that β1 > β2
Metoprolol
Atenolol
Betaxolol
Nebivolol
* Esmolol
TYROSINE HYDROXYLASE INHIBITOR
- Blocks tyrosine hydroxylase
* reduces synthesis of
dopamine, norepinephrine,
and epinephrine
- Pheochromocytoma
Metyrosine
Drugs that are used for pheochromocytoma
Phenoxybenzamine
Phentolamine
Metyrosine
