CHAPTER 9 SYMPATHOMIMETIC DRUGS

Question 1

alpha1 AGONISTS
- Activates phospholipase C,
resulting in increased
intracellular calcium and
vasoconstriction
- Orthostatic hypotension

Answer 1

Midodrine

Question 2

alpha2 AGONISTS
- Inhibits adenylyl cyclase
and interacts with other
intracellular pathways
- Hypertension

Answer 2

 Clonidine

Question 3

alpha2 AGONISTS
Also used as central sympatholytics

Answer 3

α-Methyldopa, guanfacine, and guanabenz

Question 4

alpha2 AGONISTS
Prominent sedative effects and used in anesthesia

Answer 4

 Dexmedetomidine

Question 5

alpha2 AGONISTS
Used as a muscle relaxant

Answer 5

Tizanidine

Question 6

alpha2 AGONISTS
Used topically in glaucoma to reduce intraocular pressure

Answer 6

 Apraclonidine and brimonidine

Question 7

B1 AGONISTS
-Activates adenylyl cyclase,
increasing myocardial
contractility
- Cardiogenic shock, acute
heart failure

Answer 7

 Dobutamine1

Question 8

B2 AGONISTS
- Activates adenylyl cyclase
- Asthma

Answer 8

Albuterol

Question 9

B2 AGONISTS
- Activates adenylyl cyclase
- Urinary urgency

Answer 9

Mirabegron

Question 10

D1 Agonists
- Activates adenylyl cyclase
- Hypertensive emergency

Answer 10

Fenoldopam

Question 11

D2 Agonists
- Inhibits adenylyl cyclase
and interacts with other
intracellular pathways
- Parkinson’s disease,
prolactinemia

Answer 11

Bromocriptine