Stem Cells Flashcards
Which cell in the bone marrow is pluripotent and capable of reconstituting all the blood cells in bone marrow?
Hematopoietic stem cell
What is the source for autologous stem cells
Stem cells from the patient
What is the source for allogeneic stem cells
Stem cells from matched donor
What is the treatment goal for using autologous stem cells
Provide stem cell support for individuals who received high dose chemotherapy
Patient with autologous stem cell transplant with relapsed Hodgkin lymphoma. Patient has mucositis, fever, and liver toxicity. Transplant related toxicity due to what
High dose chemotherapy used to treat the cancer
Patient with autologous stem cell transplant with relapsed Hodgkin lymphoma. Patient has mucositis, fever, and liver toxicity. What level of physical activity is beneficial and safe
Passive and active ROM, ADL, ambulation as tolerated
Patient with allogenic stem cell transplant with acute myeloid leukemia. Patient developed skin rash, N & D, jaundice. Transplant related signs and symptoms due to what
Graft vs host disease (GVHD)
Patient with allogenic stem cell transplant 1.5 years later develops chronic graft vs host disease and treated with corticosteroids. What risks are associated with corticosteroids?
Myopathy and decreased bone mass
Patient treated with chimeric antigen receptor T cells. Patient is deconditioned and goal of PT is to increase mobility and physical activity. What treatment related problems may occur from use of CAR T cells
Inflammatory response known as cytokine release syndrome (CRS)
Patient treated with chimeric antigen receptor T cells. Patient is deconditioned and goal of PT is to increase mobility and physical activity. What signs or symptoms would indicate neurologic toxicity
Delirium, seizures, tremors, encephalopathy
