stem cell Flashcards

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1
Q

stem cell

A

undifferentiated cells that are ablet to differentiate into specialized cell types

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2
Q

what is a stem cell

A

a stem cell will differentiate into a self-renewal for copying and a specialized cell

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3
Q

two types of stem cells

A
  • embryonic
    -adult
    (characterized by their potency)
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3
Q

embryonic stem cells (where to find them)

A

they are found in the inner cell mass of blastocyst. They can then be cultured in a lab to grow more cells.

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4
Q

Embryonic stem cells (what they can do)

A

embryonic stem cells can make all the different types of cell in the body. they are pluripotent.

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5
Q

potency

A

stem cells are characterized by their potential to differentiate into other types of cells. this is called potency. It decreases during this.

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6
Q

Types of stem cells (potency)

A

totipotent
pluripotent
multipotent
unipotent

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7
Q

Totipotent

A

able to differentiate into all possible cell types including the placenta. The zygote up to the 16 cell morula stage consists of totipotent

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8
Q

Pluripotent

A

able to differentiate into any of the germ layers. cells from the inner cell mass of the blastocysts are pluripotent

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9
Q

Multipotent

A

able to differentiate into a closely related family of cells. For example hematopoietic stem cells from the bone marrow can become red and white blood cells or platelets

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10
Q

Unipotent

A

able to only produce cells of their own type, but have the property of self-renewal required to be labeled a stem cell. Example include (adult) muscle stem cells.

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11
Q

Germ layers

A

Ectoderm
mesoderm
endoderm

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12
Q

ectoderm

A

neuron, skin cells and pigment cells

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13
Q

Mesoderm

A

skeletal muscle, smooth muscle, cardiac muscle, red blood cells and bone cells

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14
Q

endoderm

A

stomach cells, pancreatic cells, liver cells.

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15
Q

Adult stem cells

A

undifferentiated cells found throughout the body after development

16
Q

Problem of adult stem cells

A

they are not pluripotent like embryonic stem cells making them difficult to located.

17
Q

difference between embryonic and adult stem cells

A

embryonic:
- pluripotent
- large numbers can be obtained
- easy to locate
- will divide indefinitely
- can cause immune rejection
- high ethical controversy and uncertain legal status

Adult:
- multipotent or unipotent
- limited numbers can be obtained
- difficult to isolate
- cannot divide indefinitely
- may avoid immune rejection if use patients own cells
- less ethical and legal controversy.