STDs

Question 1

Cystitis (3)

1st 2 = MC in young women

Answer 1

• • E coli (“adhesins / pili”, “motility”)
• • Staph saprophyticus (“newly-sexually active woman”)
• Proteus sp (Urease ->↑urine pH -> “struvite stones”)

Question 2

Urethritis (4)

1st 2 = same as for Cervicitis + PID

Answer 2

• Neisseria gonorrhoeae
• Chlamydia trachomatis (“glycogen inclusion bodies”)
• Ureaplasma urealyticum (Urease ->↑urine pH -> “struvite stones”)
• Trichomonas vaginalis (Flagellated Protozoa with “corkscrew motility”)

Question 3

Pyelonephritis (2)

Path (2), Urine (2)?

Answer 3

• E coli
• Staph

PATH:

• Strictures
• Urinary stasis -> Colonization

URINE:

• Hematuria
• WBC CASTS

Question 4

Cervicitis (3)

Answer 4

• N gonorrhoeae
• Chlamydia trachomatis
• Herpes (“intranuclear inclusions”)

Question 4

Vulvovaginitis (3)

Answer 4

• Gardnerella vaginalis (anaerobes)
• Candida sp
• Trichomonas vaginalis

Question 5

Bacterial Vaginosis

Answer 5

Gardnerella vaginalis (anaerobes)

Question 6

Syphilis

Answer 6

Treponema pallidum

Question 7

Chancroid

Answer 7

Haemophilus ducreyi

Question 8

Lymphogranuloma venereum

Answer 8

Chlamydia trachomatis (serotypes L1-3)

Question 9

Genital Herpes

Answer 9

HSV-2

HSV-1 less commonly

Question 10

Trichomoniasis

Answer 10

Trichomonas vaginalis

Question 11

Neisseria gonorrhoeae

Classification, Chars (4), STDs Seen In (5), Pres, DX, RX Against?

Answer 11

Gram - diplococci.

CHARS:

• IgA Protease
• Invasive (pilli)
• Antigenic variation
• Antiphagocytic

SEEN IN: Same as Chlamydia trachomatis

• Urethritis
• Cervicitis
• PID
• Epididymitis
• Prostatitis

PRES:
- Creamy purulent discharge

DX: Thayer-Martin agar

RX: Ceftriaxone

Question 12

Chlamydia trachomatis

Chars (2), Pathogenesis, RX Against (2)?

Answer 12

CHARS:

• Obligate intracellular in epithelial cells
• Glycogen inclusion bodies in cytoplasm

PATH: Type IV h-s damage -> Scarring

RX:

• Tetracyclines (Doxycycline)
• Macrolides

Question 13

Trichomonas vaginalis

Classification, Chars (2), STDs Seen In (2), RX Against?

Answer 13

Protozoa.

CHARS:

• Flagellated Protozoa
• Corkscrew motility

SEEN IN:

• Urethritis
• Vulvovaginitis (“strawberry cervix”)

RX: Metronidazole

Question 14

HPV

Chars (2), Pathogenesis, Micro Finding (CLUE),
Seen In (2)?

Answer 14

CHARS:

• dsDNA, naked, icosahedral
• “Intranuclear inclusion bodies”

PATH: HPV E6 + E7 proteins -> Inactivate cellular antioncogene.

FINDING: “Koilocytotic atypia”

SEEN IN:

• Condyloma Acuminatum (HPV-6 + -11)
• Cervical Ca