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OS Reproductive > STD Pharm > Flashcards

STD Pharm Flashcards

1
Q

HSV drugs

A

FAV (HSV is my FAV)
Famciclovir
Acyclovir
Valacyclovir

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2
Q

HSV tx regiment

A

7-10 day oral

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3
Q

What’s that enzyme needed by some agents that phosphorylates them

A

thymidine kinases

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4
Q

Famciclovir is metabolized to:

A

penciclovir

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5
Q

Acyclovir toxicity

A

Neurotoxic inc. seizures

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6
Q

Valacyclovir toxicity

A

neurotoxic

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7
Q

Why is valacyclovir better than acyclovir

A

better oral bioavailability

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8
Q

Syphilis drugs

A

Benzathine-Penicillin G (IM)
Poor CSF penetration
rapid renal tubular excretion

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9
Q

Congenital syphilis tx course

A

10 days; if more than one day missed, start again

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10
Q

What is the Jarisch-Herxheimer reaction?

A

Flu-like symptoms a few hours post-penicillin for syphillis

Lesions may become more powerful

Do NOT discontinue
ASA for symptoms

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11
Q

Chlamydia drugs

A

Azithromycin or Doxy
Erythromycin, Levofloxacin, Ofloxacin are alts

Pregnancy: Amoxicillin (doesn’t cross placenta Cat B)

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12
Q

Azithromycin MOA

A

50S static

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13
Q

Doxycycline MOA

A

30S static

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14
Q

Erythromycin MOA

A

50S static

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15
Q

Levofloxacin and ofloxacin MOA

A

DNA gyrase II and topo IV inhibitors

bactericidal

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16
Q

Amoxicillin MOA

A

beta lactam binds PBPs - cell lysis

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17
Q

Levo and ofloxacin ADME

A 
Renal excretion (dose dec)
Taste disturbance (levo)
GI
BBW for tendonitis and rupture
BBW make myalgias worse (avoid with MG)
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18
Q

Doxy AEs

A

Hepatic damage in HD esp pregnancy

Photosensitivity

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19
Q

Erythromycin ADME and AEs

A

Inactivated by gastric acid
CYP3A4 inhibitor

GI upset

20
Q

Chancroid drugs

A

Azithromycin, Ceftriaxone, Ciprofloxacin, Erythromycin

Cipro C/I pregnancy

21
Q

Cipro mechanism

A

DNA gyrase / topo IV, bactericidal

22
Q

GC genital uncomplicated drugs

A

Ceftriaxone, Cefixime + Azithro or Doxy

23
Q

GC pharynx drugs

A

Ceftriaxone + Azithromycin or Doxy

24
Q

Cefixime AEs

A

GI, increase clotting time, false positive urinary glucose in diabetics

25
Q

Urethritis and cervicitis drugs

A

Azithromycin or Doxy, alt Erythromycin or levo of ofloxacin

26
Q

Recurrent urethritis/cervicitis drugs

A

(metronidazole or tinidazole) plus Azithromycin (If azithro not tried yet)

27
Q

Trichomoniasis drugs

A

Metronidazole or tinidazole

28
Q

Metronidazole / tinidazole MOA

A

Amebecidal, bactericidal, trichomonacidal

Taken up, reduced to active form, disrupts DNA helical structure (dividing and non)

29
Q

Metro/tinidazole ADME

A

Extensive hepatic metabolism

30
Q

Metro/tinidazole issues

A

Avoid in prego and breastfeeding
GI upset
Candidiasis
Disulfiram-like effect (no alcohol few days after therapy!)

31
Q

Bacterial vaginosis drugs

A

Metronidazole plus tinidazole, or

clindamycin plus tinidazole

32
Q

Clindamycin MOA

A

50S, static

33
Q

Clindamycin issues

A

Intravaginal use only in 1st trimester bc of AEs like low birth wt, pre-term delivery, etc.

34
Q

Candidiasis drugs

A

A conazole

35
Q

Conazoles MOA

A

block ergosterol synthesis by binding 14-alpha demethylase

36
Q

Conazoles ADME

A

Limited systemic abs

Fluconazole widely distributed in tissues/fluids

37
Q

Conazoles AEs

A

High doses may produce abdominal wall defects and cleft palate (avoid in 1st trimester)

38
Q

Gardasil strains

A

6, 11, 16, 18

39
Q

Cervarix strains

A

16, 18

40
Q

HPV vaccine target

A

L1, the major antigen of capsid

41
Q

Genital warts strains?

A

HPV 6 and 11

42
Q

Genital warts drugs

A

Podofilox, imiquimod, sinecatechins

43
Q

Podofilox MOA

A

mitotic spindle inhibitor blocking MT activity in keratinocytes

44
Q

Imiquimod MOA

A

Immune response modifier

45
Q

Sinecatechins MOA and AEs

A

Green tea extract antioxidant

Application site discomfort

OS Reproductive (9 decks)

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