SSRIs Flashcards
1
Q
CYP450 inducers?
A
1) Smoking
2) Carbamazepine
3) Barbs
4) St. John’s wort
2
Q
CYP450 inhibitors?
A
1) Fluvoxamine
2) Fluoxetine
3) Paroxetine
4) Duloxetine
5) Sertraline
3
Q
How to dose?
A
Daily (except fluoxetine, weekly)
4
Q
Elevates levels of neuroleptics?
A
Fluoxetine
5
Q
Safe in pregnancy and in children?
A
Fluoxetine
6
Q
Highest risk for GI AEs?
A
Sertraline
7
Q
Highly protein bound causing drug interactions?
A
Paroxetine
8
Q
Anticholinergic AEs?
A
Paroxetine
9
Q
Only used for OCD?
A
Fluvoxamine
10
Q
Tons of drug interactions?
A
Fluvoxamine
11
Q
Fewest drug drug interactions?
A
Citalopram
12
Q
Fewer sexual AEs?
A
Citalopram
13
Q
Most likely to cause withdrawal phenomena?
A
Paroxetine (very short half life)
14
Q
Depressed person on SSRIs doesnt like sexual AEs, what do you do?
A
Rx bupropion or non-SSRI antidepressant
