Antipsychotics

Question 1

Which group is more lethal in OD due to QTc prolongation, heart block, and v-tach?

Answer 1

Low potency typicals

Question 2

AEs of chlorpromazine?

Answer 2

1) Orthostatic hypotension
2) Bluish skin discoloration
3) Photosensitivity
4) Corneal deposits

Question 3

AEs of thioridazine?

Answer 3

Retinitis pigmentosa

Question 4

AEs of loxapine?

Answer 4

Seizures

Question 5

AEs of thiothixen?

Answer 5

Ocular pigment changes

Question 6

Which can reduce anxiety?

Answer 6

Trifluoperazine

Question 7

Which high potency may cause heart block and v-tach?

Answer 7

Pimozide

Question 8

Low potency?

Answer 8

1) Chlorpromazine

2) Thioridazine

Question 9

Midpotency?

Answer 9

1) Loxapine
2) Thiothixene
3) Trifluoperazine
4) Perphenazine

Question 10

High potency?

Answer 10

1) Haloperidol
2) Fluphenazine
3) Pimozide

Question 11

How to quantify and monitor tardive dyskinesia?

Answer 11

Abnormal Involuntary Mvt Scale (AIMS)

Question 12

Atypical most likely to cause EPS?

Answer 12

Risperidone

Question 13

Atypical least likely to cause EPS?

Answer 13

Clozapine

Question 14

AEs of clozapine?

Answer 14

1) Agranulocytosis
2) Tachycardia
3) Hypersalivation
4) Myocarditis
5) Seizures

Question 15

When to stop clozapine?

Answer 15

When neutrophil count drops <1500

Question 16

Most likely to increase prolactin?

Answer 16

Risperidone

Question 17

AEs of risperidone?

Answer 17

1) High prolactin
2) Orthostatic hypotension
3) Reflex tach

Question 18

AEs of quetiapine?

Answer 18

1) Sedation
2) Orthostatic hypotension
3) Cataracts

Question 19

Weight gain?

Answer 19

Olazapine

Question 20

Weight neutral?

Answer 20

1) Ziprasidone

2) Aripiprazole

Question 21

Take with food?

Answer 21

1) Ziprasidone

2) Lurasidone

Question 22

Long acting injectables?

Answer 22

1) Haloperidol
2) Fluphenazine
3) Risperidone
4) Paliperidone

Question 23

Partial D2 agonism?

Answer 23

Aripiprazole